Mouse spontaneous behavior reflects individual variation rather than estrous state

Current Biology, Journal Year: 2023, Volume and Issue: 33(7), P. 1358 - 1364.e4

Published: March 7, 2023

Behavior is shaped by both the internal state of an animal and its individual behavioral biases. Rhythmic variation in gonadal hormones during estrous cycle a defining feature female state, one that regulates many aspects sociosexual behavior. However, it remains unclear whether influences spontaneous behavior and, if so, how these effects might relate to variation. Here, we address this question longitudinally characterizing open-field mice across different phases cycle, using unsupervised machine learning decompose into constituent elements.

Language: Английский

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The physiological control of eating: signals, neurons, and networks

Physiological Reviews, Journal Year: 2021, Volume and Issue: 102(2), P. 689 - 813

Published: Sept. 6, 2021

During the past 30 yr, investigating physiology of eating behaviors has generated a truly vast literature. This is fueled in part by dramatic increase obesity and its comorbidities that coincided with an ever increasing sophistication genetically based manipulations. These techniques have produced results remarkable degree cell specificity, particularly at signaling level, played lead role advancing field. However, putting these findings into brain-wide context connects physiological signals neurons to behavior somatic requires thorough consideration neuronal connections: field also seen extraordinary technological revolution. Our goal present comprehensive balanced assessment how associated energy homeostasis interact many brain levels control behaviors. A major theme engage sets interacting neural networks throughout are defined specific connections. We begin discussing some fundamental concepts, including ones still engender vigorous debate, provide necessary frameworks for understanding controls meal initiation termination. include key word definitions, ATP availability as pivotal regulated variable homeostasis, neuropeptide signaling, homeostatic hedonic eating, structure. Within this context, we discuss network models regions endbrain (or telencephalon), hypothalamus, hindbrain, medulla, vagus nerve, spinal cord work together gastrointestinal tract enable complex motor events permit animals eat diverse situations.

Language: Английский

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The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation

Cell, Journal Year: 2021, Volume and Issue: 184(6), P. 1500 - 1516

Published: March 1, 2021

Social homeostasis is the ability of individuals to detect quantity and quality social contact, compare it an established set-point in a command center, adjust effort expended seek optimal contact expressed via effector system. becomes positive or negative valence stimulus when deficient excess, respectively. Chronic deficits lead adaptations such that reintroduction previous optimum experienced as surplus. Here, we build upon models for include lasting changes environmental conditions, with chronic isolation.

Language: Английский

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Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding

Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(7), P. 836 - 847

Published: July 25, 2022

Language: Английский

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Hunger games search algorithm for global optimization of engineering design problems

Materials Testing, Journal Year: 2022, Volume and Issue: 64(4), P. 524 - 532

Published: April 1, 2022

Abstract The modernization in automobile industries has been booming recent times, which led to the development of lightweight and fuel-efficient design different components. Furthermore, metaheuristic algorithms play a significant role obtaining superior optimized designs for vehicle Hence, hunger game search (HGS) algorithm is applied optimize suspension arm (SA) by reduction mass vis-à-vis volume. performance HGS was accomplished comparing achieved results with well-established metaheuristics (MHs), such as salp swarm optimizer, equilibrium Harris Hawks optimizer (HHO), chaotic HHO, slime mould marine predator artificial bee colony ant lion it found that able pursue best solution subjecting critical constraints. Moreover, can realize least weight SA subjected maximum stress values. adopted be robust terms global optimum solution.

Language: Английский

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Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(3), P. 473 - 493

Published: Feb. 20, 2024

Abstract Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-expressing neurons reciprocally regulate food intake. Here, we combine non-interacting recombinases to simultaneously express functionally opposing chemogenetic receptors in AgRP POMC for comparing metabolic responses male female mice with simultaneous activation of inhibition isolated or neurons. We show that intake is regulated by the additive effect neuron inhibition, while systemic insulin sensitivity gluconeogenesis are differentially modulated isolated-versus-simultaneous regulation identify a neurocircuit engaging Npy1R-expressing paraventricular nucleus hypothalamus, where activated inhibited cooperate promote consumption activate Th + tractus solitarii. Collectively, these results unveil how precisely bidirectional interplay between neurocircuits.

Language: Английский

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Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward

Neuron, Journal Year: 2019, Volume and Issue: 102(5), P. 1037 - 1052.e7

Published: April 24, 2019

Language: Английский

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Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State

Cell Metabolism, Journal Year: 2018, Volume and Issue: 29(3), P. 681 - 694.e5

Published: Nov. 21, 2018

Language: Английский

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AgRP Neurons Can Increase Food Intake during Conditions of Appetite Suppression and Inhibit Anorexigenic Parabrachial Neurons

Journal of Neuroscience, Journal Year: 2017, Volume and Issue: 37(36), P. 8678 - 8687

Published: Aug. 7, 2017

To maintain energy homeostasis, orexigenic (appetite-inducing) and anorexigenic (appetite suppressing) brain systems functionally interact to regulate food intake. Within the hypothalamus, neurons that express agouti-related protein (AgRP) sense factors orchestrate an increase in food-seeking behavior. In contrast, calcitonin gene-related peptide (CGRP)-expressing parabrachial nucleus (PBN) suppress feeding. PBN CGRP become active response hormones released following a meal, including amylin, secreted by pancreas, cholecystokinin (CCK), small intestine. Additionally, exogenous compounds, such as lithium chloride (LiCl), salt creates gastric discomfort, lipopolysaccharide (LPS), bacterial cell wall component induces inflammation, exert appetite-suppressing effects activate neurons. The of increasing homeostatic drive eat on feeding behavior during appetite suppressing conditions are unknown. Here, we show mice deprivation or optogenetic activation AgRP overcome CCK, LiCl, but not LPS. neuron photostimulation can also chemogenetic-mediated stimulation reduces Fos expression across all conditions. Finally, projections from increases administration These results demonstrate sufficient noninflammatory-based suppression decrease activity neurons, thereby intake need.SIGNIFICANCE STATEMENT motivation depends relative balance distinct regions induce appetite. An abnormal amount cause obesity, whereas malnutrition severe reduction body weight. purpose this study was determine whether population known ("AgRP neurons") could appetite-suppression various compounds. We found stimulating forms neural separate providing new insights into how regulates

Language: Английский

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A neural circuit mechanism for mechanosensory feedback control of ingestion

Nature, Journal Year: 2020, Volume and Issue: 580(7803), P. 376 - 380

Published: April 8, 2020

Language: Английский

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