Revisiting the Functional Anatomy of the Human Brain: Toward a Meta-Networking Theory of Cerebral Functions DOI
Guillaume Herbet, Hugues Duffau

Physiological Reviews, Journal Year: 2020, Volume and Issue: 100(3), P. 1181 - 1228

Published: Feb. 20, 2020

For more than one century, brain processing was mainly thought in a localizationist framework, which given function underpinned by discrete, isolated cortical area, and with similar cerebral organization across individuals. However, advances mapping techniques humans have provided new insights into the organizational principles of anatomo-functional architecture. Here, we review recent findings gained from neuroimaging, electrophysiological, as well lesion studies. Based on these data connectome, challenge traditional, outdated view propose an alternative meta-networking theory. This model holds that complex cognitions behaviors arise spatiotemporal integration distributed but relatively specialized networks underlying conation cognition (e.g., language, spatial cognition). Dynamic interactions between such circuits result perpetual succession equilibrium states, opening door to considerable interindividual behavioral variability neuroplastic phenomena. Indeed, underlies uniquely human propensity learn abilities, also explains how postlesional reshaping can lead some degrees functional compensation brain-damaged patients. We discuss major implications this approach fundamental neurosciences for clinical developments, especially neurology, psychiatry, neurorehabilitation, restorative neurosurgery.

Language: Английский

Functional Brain Networks Are Dominated by Stable Group and Individual Factors, Not Cognitive or Daily Variation DOI Creative Commons
Caterina Gratton, Timothy O. Laumann, Ashley N. Nielsen

et al.

Neuron, Journal Year: 2018, Volume and Issue: 98(2), P. 439 - 452.e5

Published: April 1, 2018

Language: Английский

Citations

855
Brain network dynamics are hierarchically organized in time DOI Open Access
Diego Vidaurre, Stephen M. Smith, Mark W. Woolrich

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(48), P. 12827 - 12832

Published: Oct. 30, 2017

The brain recruits neuronal populations in a temporally coordinated manner task and at rest. However, the extent to which large-scale networks exhibit their own organized temporal dynamics is unclear. We use an approach designed find repeating network patterns whole-brain resting fMRI data, where are defined as graphs of interacting areas. that transitions between nonrandom, with certain more likely occur after others. Further, this nonrandom sequencing itself hierarchically organized, revealing two distinct sets networks, or metastates, has tendency cycle within. One metastate associated sensory motor regions, other involves areas related higher order cognition. Moreover, we proportion time subject spends each consistent subject-specific measure, heritable, shows significant relationship cognitive traits.

Language: Английский

Citations

794
Questions and controversies in the study of time-varying functional connectivity in resting fMRI DOI Creative Commons
Daniel J. Lurie, Daniel Kessler, Danielle S. Bassett

et al.

Network Neuroscience, Journal Year: 2019, Volume and Issue: 4(1), P. 30 - 69

Published: Dec. 16, 2019

The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge the spatiotemporal organization these interactions critical for establishing solid understanding brain's functional architecture and relationship between neural dynamics cognition in health disease. possibility studying through careful analysis neuroimaging data has catalyzed substantial interest methods that estimate time-resolved fluctuations connectivity (often referred to as "dynamic" or time-varying connectivity; TVFC). At same time, debates have emerged regarding application TVFC analyses resting fMRI data, about statistical validity, physiological origins, cognitive behavioral relevance TVFC. These other unresolved issues complicate interpretation findings limit insights can be gained from this promising new research area. This article brings together scientists with variety perspectives on review current literature light issues. We introduce core concepts, define key terms, summarize controversies open questions, present forward-looking perspective how rigorously productively applied investigate wide range questions systems neuroscience.

Language: Английский

Citations

551
Human cognition involves the dynamic integration of neural activity and neuromodulatory systems DOI
James M. Shine, Michael Breakspear, Peter T. Bell

et al.

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(2), P. 289 - 296

Published: Jan. 12, 2019

Language: Английский

Citations

481
Human consciousness is supported by dynamic complex patterns of brain signal coordination DOI Creative Commons
Athéna Demertzi, Enzo Tagliazucchi, Stanislas Dehaene

et al.

Science Advances, Journal Year: 2019, Volume and Issue: 5(2)

Published: Feb. 1, 2019

Dynamic patterns of brain activity at rest distinguish conscious and unconscious states in humans.

Language: Английский

Citations

450
A cross-disorder connectome landscape of brain dysconnectivity DOI
Martijn P. van den Heuvel, Olaf Sporns

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(7), P. 435 - 446

Published: May 24, 2019

Language: Английский

Citations

399
The role of PFC networks in cognitive control and executive function DOI Open Access
Vinod Menon, Mark D’Esposito

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 90 - 103

Published: Aug. 18, 2021

Language: Английский

Citations

390
Segregated Systems of Human Brain Networks DOI Creative Commons
Gagan S. Wig

Trends in Cognitive Sciences, Journal Year: 2017, Volume and Issue: 21(12), P. 981 - 996

Published: Nov. 1, 2017

The organization of the brain network enables its function. Evaluation this has revealed that large-scale networks consist multiple segregated subnetworks interacting areas. Descriptions resting-state architecture have provided clues for understanding functional significance these subnetworks, many which correspond to distinct systems. present report synthesizes accumulating evidence reveal how maintaining systems renders human functionally specialized, adaptable task demands, and largely resilient following focal damage. organizational properties support system segregation are harmonious with promote integration across network, but confer unique important features central function behavior.

Language: Английский

Citations

335
An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings DOI Creative Commons
Pedro Alves, Chris Foulon, Vyacheslav Karolis

et al.

Communications Biology, Journal Year: 2019, Volume and Issue: 2(1)

Published: Oct. 10, 2019

Abstract The brain is constituted of multiple networks functionally correlated areas, out which the default-mode network (DMN) largest. Most existing research into DMN has taken a corticocentric approach. Despite its resemblance with unitary model limbic system, contribution subcortical structures to may be underappreciated. Here, we propose more comprehensive neuroanatomical including such as basal forebrain, cholinergic nuclei, anterior and mediodorsal thalamic nuclei. Additionally, tractography diffusion-weighted imaging was employed explore structural connectivity, revealed that thalamus forebrain are central importance for functioning DMN. these neurochemically diverse nuclei reconciles previous neuroimaging neuropathological findings in diseased brains offers potential identifying conserved homologue other mammalian species.

Language: Английский

Citations

318
Network Neuroscience Theory of Human Intelligence DOI Creative Commons
Aron K. Barbey

Trends in Cognitive Sciences, Journal Year: 2017, Volume and Issue: 22(1), P. 8 - 20

Published: Nov. 21, 2017

TrendsAccumulating evidence from network neuroscience indicates that g depends on the dynamic reorganization of brain networks, modifying their topology and community structure in service system-wide flexibility adaptation.Whereas crystallized intelligence engages easy-to-reach states access prior knowledge experience, fluid recruits difficult-to-reach support cognitive adaptive problem-solving.The capacity to flexibly transition between networks therefore provides basis for – enabling rapid information exchange across capturing individual differences processing at a global level.This framework sets stage new approaches understanding neural foundations g, examining dynamics.AbstractAn enduring aim research psychological sciences is understand nature human intelligence, stunning breadth diversity intellectual abilities remarkable neurobiological mechanisms which they arise. This Opinion article surveys recent elucidate how general emerges architecture brain. The reviewed findings motivate insights about dynamics account represented by Network Neuroscience Theory. According this framework, small-world its adaptation.

Language: Английский

Citations

313