Targeted neurostimulation reverses a spatiotemporal biomarker of treatment-resistant depression DOI Creative Commons
Anish Mitra, Marcus E. Raichle, Andrew Geoly

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(21)

Published: May 15, 2023

Major depressive disorder (MDD) is widely hypothesized to result from disordered communication across brain-wide networks. Yet, prior resting-state-functional MRI (rs-fMRI) studies of MDD have studied zero-lag temporal synchrony (functional connectivity) in brain activity absent directional information. We utilize the recent discovery stereotyped directed signaling patterns humans investigate relationship between rs-fMRI activity, MDD, and treatment response FDA-approved neurostimulation paradigm termed Stanford neuromodulation therapy (SNT). find that SNT over left dorsolateral prefrontal cortex (DLPFC) induces shifts DLPFC bilateral anterior cingulate (ACC). Directional ACC, but not DLPFC, predict improvement depression symptoms, moreover, pretreatment ACC predicts both severity likelihood response. Taken together, our findings suggest ACC-based are a potential biomarker MDD.

Language: Английский

Spatial and Temporal Organization of the Individual Human Cerebellum DOI Creative Commons
Scott Marek, Joshua S. Siegel, Evan M. Gordon

et al.

Neuron, Journal Year: 2018, Volume and Issue: 100(4), P. 977 - 993.e7

Published: Oct. 25, 2018

Language: Английский

Citations

274
Neuromodulation of Brain State and Behavior DOI Open Access
David A. McCormick, Dennis Nestvogel, Biyu J. He

et al.

Annual Review of Neuroscience, Journal Year: 2020, Volume and Issue: 43(1), P. 391 - 415

Published: April 6, 2020

Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans animals reveal that these variations not random their nature, but may fact be due large part to rapid shifts neural, cognitive, behavioral states. Here we review recent advances the understanding waking state, how generated, they modulate neural mice humans. We propose brain has an identifiable set states through which it wanders continuously a nonrandom fashion, owing ascending modulatory fast-acting corticocortical subcortical-cortical pathways. These state provide backdrop upon operates, them is critical making progress revealing mechanisms underlying cognition behavior.

Language: Английский

Citations

250
Hierarchical dynamics as a macroscopic organizing principle of the human brain DOI Open Access
Ryan V. Raut, Abraham Z. Snyder, Marcus E. Raichle

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(34), P. 20890 - 20897

Published: Aug. 12, 2020

Multimodal evidence suggests that brain regions accumulate information over timescales vary according to anatomical hierarchy. Thus, these experimentally defined "temporal receptive windows" are longest in cortical distant from sensory input. Interestingly, spontaneous activity also plays out relatively slow (i.e., exhibits slower temporal autocorrelation decay). These findings raise the possibility hierarchical represent an intrinsic organizing principle of function. Here, using resting-state functional MRI, we show timescale ongoing dynamics follows spatial gradients throughout human cerebral cortex. give rise systematic frequency differences among large-scale networks and predict individual-specific features connectivity. Whole-brain coverage permitted us further investigate organization subcortical dynamics. We topographically mirrored striatum, thalamus, cerebellum. Finally, hippocampus followed a posterior-to-anterior gradient, corresponding longitudinal axis increasing representational scale. emerge as global mammalian brains.

Language: Английский

Citations

219
The Default Mode Network’s Role in Discrete Emotion DOI
Ajay B. Satpute, Kristen A. Lindquist

Trends in Cognitive Sciences, Journal Year: 2019, Volume and Issue: 23(10), P. 851 - 864

Published: Aug. 16, 2019

Language: Английский

Citations

216
Global waves synchronize the brain’s functional systems with fluctuating arousal DOI Creative Commons
Ryan V. Raut, Abraham Z. Snyder, Anish Mitra

et al.

Science Advances, Journal Year: 2021, Volume and Issue: 7(30)

Published: July 21, 2021

Traveling waves spatiotemporally organize brain-wide activity in synchrony with ongoing arousal fluctuations.

Language: Английский

Citations

191
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task DOI Open Access

David B. Salkoff,

Edward Zagha, Erin McCarthy

et al.

Cerebral Cortex, Journal Year: 2019, Volume and Issue: 30(1), P. 421 - 437

Published: Aug. 17, 2019

Abstract Recent studies in mice reveal widespread cortical signals during task performance; however, the various task-related and task-independent processes underlying this activity are incompletely understood. Here, we recorded wide-field neural activity, as revealed by GCaMP6s, from dorsal cortex while simultaneously monitoring orofacial movements, walking, arousal (pupil diameter) of head-fixed performing a Go/NoGo visual detection examined ability performance spontaneous or movements to predict activity. A linear model was able explain significant fraction (33–55% variance) widefield with largest factors being (facial, walk, eye), response choice (hit, miss, false alarm), indicate that trial-to-trial variability arises both changes state (e.g., arousal). Importantly, secondary motor highly correlated lick rate, critical for optimal (high d′), first region significantly on target trials. These findings suggest is critically involved decision learned variation results variations behavioral/arousal state.

Language: Английский

Citations

171
Default-mode network streams for coupling to language and control systems DOI Open Access
Evan M. Gordon, Timothy O. Laumann, Scott Marek

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(29), P. 17308 - 17319

Published: July 6, 2020

Significance The human brain is organized into large networks. One important network the Default network, which enables cognitive functions such as social thinking, memory, and reward. In group-averaged data, this emerges a unitary whole, despite its involvement in multiple functions. Here, we tested whether networks found individual humans, rather than group-average networks, contain substructure. individuals, consistently nine subnetworks within network. These matched activity patterns during tasks. Some resembled circuits involved specific Others linked to other summary, study describes set of humans.

Language: Английский

Citations

149
The secret life of predictive brains: what’s spontaneous activity for? DOI
Giovanni Pezzulo, Marco Zorzi, Maurizio Corbetta

et al.

Trends in Cognitive Sciences, Journal Year: 2021, Volume and Issue: 25(9), P. 730 - 743

Published: June 16, 2021

Language: Английский

Citations

134
Why is everyone talking about brain state? DOI Creative Commons
Abigail S. Greene, Corey Horien, Daniel Barson

et al.

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(7), P. 508 - 524

Published: May 8, 2023

The rapid and coordinated propagation of neural activity across the brain provides foundation for complex behavior cognition. Technical advances neuroscience subfields have advanced understanding these dynamics, but points convergence are often obscured by semantic differences, creating silos subfield-specific findings. In this review we describe how a parsimonious conceptualization state as fundamental building block whole-brain offers common framework to relate findings scales species. We present examples diverse techniques commonly used study states associated with physiology higher-order cognitive processes, discuss integration them will enable more comprehensive mechanistic characterization dynamics that crucial survival disrupted in disease.

Language: Английский

Citations

82
Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex DOI Creative Commons
Federico Rocchi,

Carola Canella,

Shahryar Noei

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Feb. 25, 2022

Abstract While shaped and constrained by axonal connections, fMRI-based functional connectivity reorganizes in response to varying interareal input or pathological perturbations. However, the causal contribution of regional brain activity whole-brain fMRI network organization remains unclear. Here we combine neural manipulations, resting-state vivo electrophysiology probe how inactivation a cortical node causally affects brain-wide coupling mouse. We find that chronic inhibition medial prefrontal cortex (PFC) via overexpression potassium channel increases between inhibited area its direct thalamo-cortical targets. Acute chemogenetic PFC produces analogous patterns overconnectivity. Using electrophysiology, enhances low frequency (0.1–4 Hz) oscillatory power suppression firing not phase-locked slow rhythms, resulting increased δ band coherence areas exhibit These results provide evidence can counterintuitively increase enhanced, less-localized processes.

Language: Английский

Citations

73