Evidence for domain-general arousal from semantic and neuroimaging meta-analyses reconciles opposing views on arousal DOI Creative Commons
Magdalena Sabat, Charles de Dampierre, Catherine Tallon‐Baudry

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(6)

Published: Feb. 3, 2025

Arousal refers to changes in brain-body state underpinning motivated behavior but lacks a proper definition and taxonomy. Neuroscience psychology textbooks offer surprisingly different views on what arousal is, from global brain-wide modulation of neuronal activity multidimensional construct, with specific patterns tuned given situation. The huge number scientific articles mentioning (~50,000) highlights the importance concept also explains why such vast literature has never been systematically reviewed so far. Here, we leverage tools natural language processing probe nature data-driven, comprehensive manner. We show that comes seven varieties: cognitive, emotional, physiological, sexual, related stress disorders, sleep, or sleep disorders. then ask whether domain-general exists at cortical level, run meta-analyses brain imaging reveal all varieties arousal, except disorders for lack data, converge onto network composed presupplementary motor area left right dorsal anterior insula. More precisely, find dysgranular insular 7 (Jülich atlas), region highest convergence across is specifically associated arousal. might trigger reorganization large-scale networks-a mechanism-resulting context-specific configuration-in line view. Future taxonomies refining alignment between concepts data should include as central component.

Language: Английский

Geometric constraints on human brain function DOI Creative Commons
James C. Pang, Kevin Aquino, Marianne Oldehinkel

et al.

Nature, Journal Year: 2023, Volume and Issue: 618(7965), P. 566 - 574

Published: May 31, 2023

The anatomy of the brain necessarily constrains its function, but precisely how remains unclear. classical and dominant paradigm in neuroscience is that neuronal dynamics are driven by interactions between discrete, functionally specialized cell populations connected a complex array axonal fibres

Language: Английский

Citations

230
Human brain effects of DMT assessed via EEG-fMRI DOI Creative Commons
Christopher Timmermann, Leor Roseman,

Sharad Haridas

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(13)

Published: March 20, 2023

Psychedelics have attracted medical interest, but their effects on human brain function are incompletely understood. In a comprehensive, within-subjects, placebo-controlled design, we acquired multimodal neuroimaging [i.e., EEG-fMRI (electroencephalography-functional MRI)] data to assess the of intravenous (IV) N,N-Dimethyltryptamine (DMT) in 20 healthy volunteers. Simultaneous was prior to, during, and after bolus IV administration mg DMT, and, separately, placebo. At dosages consistent with present study, serotonin 2A receptor (5-HT2AR) agonist, induces deeply immersive radically altered state consciousness. DMT is thus useful research tool for probing neural correlates conscious experience. Here, fMRI results revealed robust increases global functional connectivity (GFC), network disintegration desegregation, compression principal cortical gradient under DMT. GFC × subjective intensity maps correlated independent positron emission tomography (PET)-derived 5-HT2AR maps, both overlapped meta-analytical implying human-specific psychological functions. Changes major EEG-measured neurophysiological properties specific changes various metrics, enriching our understanding basis DMT’s effects. The findings advance previous work by confirming predominant action DMT—and likely other agonist psychedelics—on brain’s transmodal association pole, i.e., neurodevelopmentally evolutionarily recent cortex that associated species-specific advancements, high expression 5-HT2A receptors.

Language: Английский

Citations

135
A parsimonious description of global functional brain organization in three spatiotemporal patterns DOI
Taylor Bolt, Jason S. Nomi, Danilo Bzdok

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(8), P. 1093 - 1103

Published: July 28, 2022

Language: Английский

Citations

101
Why is everyone talking about brain state? DOI Creative Commons
Abigail S. Greene, Corey Horien, Daniel Barson

et al.

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(7), P. 508 - 524

Published: May 8, 2023

The rapid and coordinated propagation of neural activity across the brain provides foundation for complex behavior cognition. Technical advances neuroscience subfields have advanced understanding these dynamics, but points convergence are often obscured by semantic differences, creating silos subfield-specific findings. In this review we describe how a parsimonious conceptualization state as fundamental building block whole-brain offers common framework to relate findings scales species. We present examples diverse techniques commonly used study states associated with physiology higher-order cognitive processes, discuss integration them will enable more comprehensive mechanistic characterization dynamics that crucial survival disrupted in disease.

Language: Английский

Citations

80
Functional geometry of the cortex encodes dimensions of consciousness DOI Creative Commons
Zirui Huang, George A. Mashour, Anthony G. Hudetz

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 5, 2023

Abstract Consciousness is a multidimensional phenomenon, but key dimensions such as awareness and wakefulness have been described conceptually rather than neurobiologically. We hypothesize that of consciousness are encoded in multiple neurofunctional the brain. analyze cortical gradients, which continua brain’s overarching functional geometry, to characterize these dimensions. demonstrate disruptions human – due pharmacological, neuropathological, or psychiatric causes associated with degradation one more major gradients depending on state. Network-specific reconfigurations within gradient space behavioral unresponsiveness various etiologies, spatial correlate temporal disruption structured transitions dynamic brain states. In this work, we therefore provide unifying framework for both health disease.

Language: Английский

Citations

77
Intrinsic macroscale oscillatory modes driving long range functional connectivity in female rat brains detected by ultrafast fMRI DOI Creative Commons
Joana Cabral, Francisca F. Fernandes, Noam Shemesh

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 6, 2023

Abstract Spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals correlate across distant brain areas, shaping functionally relevant intrinsic networks. However, the generative mechanism of fMRI signal correlations, and particular link with locally-detected ultra-slow oscillations, are not fully understood. To investigate this link, we record ultrafast ultrahigh field (9.4 Tesla, temporal resolution = 38 milliseconds) from female rats three anesthesia conditions. Power at frequencies extending up to 0.3 Hz is detected consistently rat brains modulated by level. Principal component analysis reveals a repertoire modes, which transient oscillations organize fixed phase relationships distinct cortical subcortical structures. Oscillatory modes found vary between conditions, resonating faster under medetomidine sedation reducing both number, frequency, duration addition isoflurane. Peaking power within clear anatomical boundaries, these oscillatory point an emergent systemic property. This work provides additional insight into origin organizing principles underpinning spontaneous long-range connectivity.

Language: Английский

Citations

53
Neurobehavioral meaning of pupil size DOI Creative Commons
Nikola Grujic, Rafael Polanìa, Denis Burdakov

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(20), P. 3381 - 3395

Published: June 25, 2024

Pupil size is a widely used metric of brain state. It one the few signals originating from that can be readily monitored with low-cost devices in basic science, clinical, and home settings. is, therefore, important to investigate generate well-defined theories related specific interpretations this metric. What exactly does it tell us about brain? Pupils constrict response light dilate during darkness, but also controls pupil irrespective luminosity. fluctuations resulting ongoing "brain states" are as arousal, what pupil-linked arousal how should interpreted neural, cognitive, computational terms? Here, we discuss some recent findings these issues. We identify open questions propose answer them through combination tasks, neurocomputational models, neurophysiological probing interconnected loops causes consequences size.

Language: Английский

Citations

17
Oscillatory Coupling Between Neural and Cardiac Rhythms DOI Creative Commons
Kaia Sargent,

Emily L. Martinez,

Alexandra C. Reed

et al.

Psychological Science, Journal Year: 2024, Volume and Issue: 35(5), P. 517 - 528

Published: April 3, 2024

Oscillations serve a critical role in organizing biological systems. In the brain, oscillatory coupling is fundamental mechanism of communication. The possibility that neural oscillations interact directly with slower physiological rhythms (e.g., heart rate, respiration) largely unexplored and may have important implications for psychological functioning. an aspect rate variability (HRV), show remarkably robust associations health. Mather Thayer proposed between high-frequency HRV (HF-HRV) as partially accounts such relationships. We tested this hypothesis by measuring phase-amplitude HF-HRV 37 healthy adults at rest. Robust was detected all frequency bands. Granger causality analyses indicated stronger heart-to-brain than brain-to-heart effects bands except gamma. These findings suggest cardiac play causal modulating oscillations, which mental

Language: Английский

Citations

16
The brain’s action-mode network DOI
Nico U.F. Dosenbach,

Marcus E. Raichle,

Evan M. Gordon

et al.

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

13
Hierarchical functional system development supports executive function DOI Creative Commons
Arielle S. Keller, Valerie J. Sydnor, Adam Pines

et al.

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 27(2), P. 160 - 174

Published: Nov. 24, 2022

Language: Английский

Citations

62