A manifold neural population code for space in hippocampal coactivity dynamics independent of place fields DOI Creative Commons

Eliott R. J. Levy,

Simón Carrillo Segura, Eunhye Park

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(10), P. 113142 - 113142

Published: Sept. 25, 2023

Hippocampus place cell discharge is temporally unreliable across seconds and days, fields are multimodal, suggesting an "ensemble cofiring" spatial coding hypothesis with manifold dynamics that does not require reliable tuning, in contrast to hypotheses based on field (spatial tuning) stability. We imaged mouse CA1 (cornu ammonis 1) ensembles two environments three weeks evaluate these hypotheses. While "remap," being more distinct between than within environments, coactivity relationships generally change less. Decoding location environment from 1-s ensemble location-specific activity effective improves experience. cell-pair also experience, even after removing tuning. Discriminating relies crucially the cells most anti-coactive because internally organized a low-dimensional of non-linear intermittently reregisters according anti-cofiring subpopulation activity.

Language: Английский

Large-scale neural recordings call for new insights to link brain and behavior DOI
Anne E. Urai, Brent Doiron, Andrew M. Leifer

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(1), P. 11 - 19

Published: Jan. 1, 2022

Language: Английский

Citations

259
Attractor and integrator networks in the brain DOI

Mikail Khona,

Ila Fiete

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(12), P. 744 - 766

Published: Nov. 3, 2022

Language: Английский

Citations

189
Inhibitory stabilization and cortical computation DOI
Sadra Sadeh, Claudia Clopath

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 22(1), P. 21 - 37

Published: Nov. 11, 2020

Language: Английский

Citations

165
Inhibition stabilization is a widespread property of cortical networks DOI Creative Commons
Alessandro Sanzeni, Bradley Akitake, Hannah C Goldbach

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: June 29, 2020

Many cortical network models use recurrent coupling strong enough to require inhibition for stabilization. Yet it has been experimentally unclear whether inhibition-stabilized (ISN) describe function well across areas and states. Here, we test several ISN predictions, including the counterintuitive (paradoxical) suppression of inhibitory firing in response optogenetic stimulation. We find clear evidence operation mouse visual, somatosensory, motor cortex. Simple two-population data let us quantify strength. Although some predict a non-ISN transition with increasingly sensory stimuli, effects without stimulation even during light anesthesia. Additionally, average paradoxical result only transgenic, not viral, opsin expression parvalbumin (PV)-positive neurons; theory show this is consistent operation. Taken together, these results stabilization are common features

Language: Английский

Citations

146
What is the dynamical regime of cerebral cortex? DOI Creative Commons
Yashar Ahmadian, Kenneth D. Miller

Neuron, Journal Year: 2021, Volume and Issue: 109(21), P. 3373 - 3391

Published: Aug. 30, 2021

Language: Английский

Citations

116
The logic of recurrent circuits in the primary visual cortex DOI Creative Commons
Ian Antón Oldenburg, William D. Hendricks, Gregory Handy

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(1), P. 137 - 147

Published: Jan. 1, 2024

Abstract Recurrent cortical activity sculpts visual perception by refining, amplifying or suppressing input. However, the rules that govern influence of recurrent remain enigmatic. We used ensemble-specific two-photon optogenetics in mouse cortex to isolate impact from external found spatial arrangement and feature preference stimulated ensemble neighboring neurons jointly determine net effect activity. Photoactivation these ensembles drives suppression all cells beyond 30 µm but uniformly activation closer similarly tuned cells. In nonsimilarly cells, compact, cotuned drive suppression, while diffuse, activation. Computational modeling suggests highly local excitatory connectivity selective convergence onto inhibitory explain effects. Our findings reveal a straightforward logic which space their on

Language: Английский

Citations

37
The computational foundations of dynamic coding in working memory DOI Creative Commons
Jake P. Stroud, John Duncan, Máté Lengyel

et al.

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(7), P. 614 - 627

Published: April 4, 2024

Working memory (WM) is a fundamental aspect of cognition. WM maintenance classically thought to rely on stable patterns neural activities. However, recent evidence shows that population activities during undergo dynamic variations before settling into pattern. Although this has been difficult explain theoretically, network models optimized for typically also exhibit such dynamics. Here, we examine versus coding in data, classical models, and task-optimized networks. We review principled mathematical reasons why do not, while naturally coding. suggest an update our understanding maintenance, which computational feature rather than epiphenomenon.

Language: Английский

Citations

18
Circuit Models of Low-Dimensional Shared Variability in Cortical Networks DOI Creative Commons
Chengcheng Huang, Douglas A. Ruff, Ryan Pyle

et al.

Neuron, Journal Year: 2018, Volume and Issue: 101(2), P. 337 - 348.e4

Published: Dec. 20, 2018

Language: Английский

Citations

156
A cortical hierarchy of localized and distributed processes revealed via dissociation of task activations, connectivity changes, and intrinsic timescales DOI Creative Commons
Takuya Ito, Luke J. Hearne, Michael W. Cole

et al.

NeuroImage, Journal Year: 2020, Volume and Issue: 221, P. 117141 - 117141

Published: July 12, 2020

Many studies have identified the role of localized and distributed cognitive functionality by mapping either local task-related activity or functional connectivity (FC). However, few directly explored relationship between a brain region's task its FC. Here we systematically evaluated differential contributions FC changes to identify processes across cortical hierarchy. We found that multiple tasks, magnitude regional task-evoked was high in unimodal areas, but low transmodal areas. In contrast, task-state significantly reduced areas relative This revealed strong negative regions associated with previously reported principal gradient macroscale organization. Moreover, this dissociation corresponded hierarchical differences intrinsic timescale estimated from resting-state fMRI region myelin content structural MRI. Together, our results contribute growing literature illustrating representing processes.

Language: Английский

Citations

128
A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex DOI Creative Commons
Andreas Keller, Mario Dipoppa, Morgane Roth

et al.

Neuron, Journal Year: 2020, Volume and Issue: 108(6), P. 1181 - 1193.e8

Published: Dec. 1, 2020

Language: Английский

Citations

118