Astrocyte Crosstalk in CNS Inflammation

Neuron, Journal Year: 2020, Volume and Issue: 108(4), P. 608 - 622

Published: Sept. 7, 2020

Language: Английский

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The Emerging Nature of Astrocyte Diversity

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 42(1), P. 187 - 207

Published: July 8, 2019

Astrocytes are morphologically complex, ubiquitous cells that viewed as a homogeneous population tiling the entire central nervous system (CNS). However, this view has been challenged in last few years with availability of RNA sequencing, immunohistochemistry, electron microscopy, morphological reconstruction, and imaging data. These studies suggest astrocytes represent diverse they display brain area– disease–specific properties functions. In review, we summarize these observations, emphasize areas where clear conclusions can be made, discuss potential unifying themes. We also identify knowledge gaps need to addressed order exploit astrocyte diversity biological phenomenon physiological relevance CNS. thus provide summary perspective on vertebrate

Language: Английский

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Function and therapeutic value of astrocytes in neurological diseases

Nature Reviews Drug Discovery, Journal Year: 2022, Volume and Issue: 21(5), P. 339 - 358

Published: Feb. 16, 2022

Language: Английский

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Astrocytes and Microglia: In Sickness and in Health

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(3), P. 144 - 154

Published: Feb. 7, 2020

Language: Английский

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Crosstalk Between Astrocytes and Microglia: An Overview

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: July 16, 2020

Based on discoveries enabled by new technologies and analyzed using novel computational tools, neuroscience can be re-conceived in terms of information exchange dense networks intercellular connections rather than the context individual populations, such as glia or neurons.. Cross-talk between neurons microglia astrocytes are has been addressed, however, manner which non-neuronal cells communicate interact remains less well understood. We review this intriguing crosstalk among CNS cells, focusing how it contributes to brain development two neurodegenerative diseases: Alzheimer disease GRN-FTLD most prevalent tumor, astrocytoma. The goal studying these communications is promote our ability combat incurable neurological disorders.

Language: Английский

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Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior

Cell, Journal Year: 2019, Volume and Issue: 178(1), P. 27 - 43.e19

Published: June 1, 2019

When a behavior repeatedly fails to achieve its goal, animals often give up and become passive, which can be strategic for preserving energy or regrouping between attempts. It is unknown how the brain identifies behavioral failures mediates this behavioral-state switch. In larval zebrafish swimming in virtual reality, visual feedback withheld so that swim attempts fail trigger expected flow. After tens of seconds such motor futility, became passive similar durations. Whole-brain calcium imaging revealed noradrenergic neurons responded specifically failed radial astrocytes whose levels accumulated with increasing numbers Using cell ablation optogenetic chemogenetic activation, we found progressively activated brainstem astrocytes, then suppressed swimming. Thus, perform computation critical behavior: they accumulate evidence current actions are ineffective consequently drive changes states. VIDEO ABSTRACT.

Language: Английский

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Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue

Cell, Journal Year: 2019, Volume and Issue: 177(5), P. 1280 - 1292.e20

Published: April 25, 2019

Language: Английский

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Improved tools to study astrocytes

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(3), P. 121 - 138

Published: Feb. 10, 2020

Language: Английский

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Questions and (some) answers on reactive astrocytes

Glia, Journal Year: 2019, Volume and Issue: 67(12), P. 2221 - 2247

Published: Aug. 19, 2019

Abstract Astrocytes are key cellular partners for neurons in the central nervous system. react to virtually all types of pathological alterations brain homeostasis by significant morphological and molecular changes. This response was classically viewed as stereotypical is called astrogliosis or astrocyte reactivity. It long considered a nonspecific, secondary reaction conditions, offering no clues on disease‐causing mechanisms with little therapeutic value. However, many studies over last 30 years have underlined crucial active roles played astrocytes physiology, ranging from metabolic support, synapse maturation, pruning fine regulation synaptic transmission. prompted researchers explore how these new functions were changed disease, they reported them (sometimes beneficial, mostly deleterious). More recently, cell‐specific transcriptomics revealed that undergo massive changes gene expression when become reactive. observation further stressed reactive may be very different normal, nonreactive could influence disease outcomes. To make picture even more complex, both normal shown molecularly functionally heterogeneous. Very known about specific each subtype play contexts. In this review, we interrogated field identify discuss points consensus controversies astrocytes, starting their name. We then present emerging knowledge cells future challenges field.

Language: Английский

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Behaviorally consequential astrocytic regulation of neural circuits

Neuron, Journal Year: 2020, Volume and Issue: 109(4), P. 576 - 596

Published: Dec. 31, 2020

Language: Английский

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