A precision functional atlas of personalized network topography and probabilities

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(5), P. 1000 - 1013

Published: March 26, 2024

Abstract Although the general location of functional neural networks is similar across individuals, there vast person-to-person topographic variability. To capture this, we implemented precision brain mapping magnetic resonance imaging methods to establish an open-source, method-flexible set network atlases—the Masonic Institute for Developing Brain (MIDB) Precision Atlas. This atlas evolving resource comprising 53,273 individual-specific maps, from more than 9,900 ages and cohorts, including Adolescent Cognitive Development study, Developmental Human Connectome Project others. We also generated probabilistic maps multiple integration zones (using a new overlapping technique, Overlapping MultiNetwork Imaging). Using regions high invariance improved reproducibility executive function statistical in brain-wide associations compared group average-based parcellations. Finally, provide potential use case targeted neuromodulation. The expandable alternative datasets with online interface encouraging scientific community explore contribute understanding human precisely.

Language: Английский

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The brain’s cingulo-opercular action-mode network

Published: Jan. 27, 2024

The brain is always intrinsically active, utilizing energy at high rates, while moving between global functional modes. Awake modes are tied to corresponding behavioral states. During goal-directed behavior, the enters an action-mode of function. In action-mode, arousal heightened, attention focused externally, and action plans created, converted movements, continuously updated based on relevant feedback, such as pain. Here, we synthesize classical recent human animal evidence that brain’s created maintained by network (AMN), which had previously identified named cingulo-opercular (CON) its anatomy. Controlling accounts for large variety functions associated with AMN, increasing arousal, processing instructional cues, task general initiation transients, sustained goal maintenance, planning, sympathetic drive (e.g., connectivity adrenal medulla) controlling physiology internal organs, well action-relevant bottom-up signals pain, errors viscerosensation. mode space, AMN-generated antipole default-mode self-referential, emotional, memory processing.

Language: Английский

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A hierarchical atlas of the human cerebellum for functional precision mapping

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 27, 2024

Language: Английский

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The brain’s action-mode network

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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Causes and Consequences of Diagnostic Heterogeneity in Depression: Paths to Discovering Novel Biological Depression Subtypes

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 88(1), P. 83 - 94

Published: Jan. 28, 2020

Language: Английский

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