Defensive responses: behaviour, the brain and the body

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(11), P. 655 - 671

Published: Sept. 20, 2023

Language: Английский

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Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons

Neuron, Journal Year: 2024, Volume and Issue: 112(6), P. 1001 - 1019.e6

Published: Jan. 25, 2024

Midbrain dopamine neurons are thought to signal reward prediction errors (RPEs), but the mechanisms underlying RPE computation, particularly contributions of different neurotransmitters, remain poorly understood. Here, we used a genetically encoded glutamate sensor examine pattern inputs in mice. We found that exhibit virtually all characteristics rather than conveying specific component such as or expectation. Notably, whereas were transiently inhibited by omission, they excited aversive stimuli. Opioid analgesics altered negative responses stimuli into more positive responses, excitatory remained unchanged. Our findings uncover previously unknown synaptic computations; shaped both synergistic and competitive interactions between glutamatergic GABAergic depending on valences, with playing role

Language: Английский

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Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Neuronal plasticity in the central amygdala (CeA) is essential for modulating feeding behaviors and emotional responses, potentially influencing reactions to Deoxynivalenol (DON). Acute oral administration of DON elicits a dose‐responsive reduction food intake, accompanied by pronounced alterations locomotor activity frequency. This study investigates circuitry adaptations that mediate DON's effects on feeding, targeting GABA neurons CeA. Following exposure DON, an increase connectivity between paraventricular nucleus thalamus (PVT) CeA observed, suggesting involvement this pathway adverse states. Chemogenetic optogenetic manipulations resulted substantial mice's overall activity. These findings suggest are involved DON‐induced anorexia aversive‐like responses. Additionally, SCN10A antagonist (A‐803467) effectively mitigated emotions, highlighting pivotal role PVT‐CeA circuit regulating physiological impacts DON. have significant implications public health clinical interventions, offering potential therapeutic strategies mitigate human health.

Language: Английский

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Translational research approach to social orienting deficits in autism: the role of superior colliculus-ventral tegmental pathway

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Abstract Autism Spectrum Disorder (ASD) is characterized by impairments in social interaction and repetitive behaviors. A key characteristic of ASD a decreased interest interactions, which affects individuals’ ability to engage with their environment. This study explores the neurobiological basis these deficits, focusing on pathway between Superior Colliculus (SC) Ventral Tegmental Area (VTA). Adopting translational approach, our research used Shank3 knockout mice ( −/ − ), parallel clinical cohort young children ASD, investigate mechanisms. We observed consistent deficits orienting across species. In fMRI analyses revealed significant decrease connectivity SC VTA. Additionally, using miniscopes mice, we identified reduction frequency calcium transients neurons projecting VTA, accompanied changes neuronal correlation intrinsic cellular properties. Notably, interneuronal functional VTA correlated severity deficits. Our findings underscore potential SC-VTA as biomarker for open new avenues therapeutic interventions, highlighting importance early detection targeted treatment strategies.

Language: Английский

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The role of the periaqueductal gray in escape behavior

Current Opinion in Neurobiology, Journal Year: 2019, Volume and Issue: 60, P. 115 - 121

Published: Dec. 19, 2019

Language: Английский

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