Detection of neuronal defensive discharge information transmission and characteristics in periaqueductal gray double-subregions using PtNP/PEDOT:PSS modified microelectrode arrays DOI Creative Commons
Botao Lu, Penghui Fan, Ming Li

et al.

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: May 31, 2023

Threatened animals respond with appropriate defensive behaviors to survive. It has been accepted that midbrain periaqueductal gray (PAG) plays an essential role in the circuitry system and organizes behavioral responses. However, correlation of different PAG subregions expression remain largely unexplored. Here, we designed manufactured a microelectrode array (MEA) simultaneously detect activities dPAG vPAG neurons freely behaving rats. To improve detection performance MEAs, PtNP/PEDOT:PSS nanocomposites were modified onto MEAs. Subsequently, predator odor was used induce rat's innate fear, changes information transmission neuronal detected vPAG. Our results showed participated but activation degree distinct defense behaviors. During flight, responses stronger earlier than vPAG, while responded more strongly during freezing. By applying high-performance MEA, it revealed neural spread from activated weakly research also exhibited discharge characteristics, regulation burst-firing patterns. The slow continuous firing cooresponded long-term freezing demonstrated important controlling aspects provided novel insights for investigating electrophysiological perspective.

Language: Английский

Space, Time, and Fear: Survival Computations along Defensive Circuits DOI
Dean Mobbs, Drew B. Headley,

Weilun Ding

et al.

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(3), P. 228 - 241

Published: Feb. 3, 2020

Language: Английский

Citations

239
The prefrontal cortex, pathological anxiety, and anxiety disorders DOI Open Access
Margaux M. Kenwood, Ned H. Kalin, Helen Barbas

et al.

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 260 - 275

Published: Aug. 16, 2021

Language: Английский

Citations

187
Social trauma engages lateral septum circuitry to occlude social reward DOI Creative Commons
Long Li, Romain Durand-de Cuttoli, Antonio Aubry

et al.

Nature, Journal Year: 2022, Volume and Issue: 613(7945), P. 696 - 703

Published: Nov. 30, 2022

Abstract In humans, traumatic social experiences can contribute to psychiatric disorders 1 . It is suggested that trauma impairs brain reward function such behaviour no longer rewarding, leading severe avoidance 2,3 rodents, the chronic defeat stress (CSDS) model has been used understand neurobiology underlying susceptibility versus resilience following trauma, yet little known regarding its impact on 4,5 Here we show that, CSDS, a subset of male and female mice, termed susceptible (SUS), avoid interaction with non-aggressive, same-sex juvenile C57BL/6J mice do not develop context-dependent encounters them. Non-social stressors have effect in either sex. Next, using whole-brain Fos mapping, vivo Ca 2+ imaging whole-cell recordings, identified population stress/threat-responsive lateral septum neurotensin (NT LS ) neurons are activated by interactions only SUS but resilient or unstressed control mice. Optogenetic chemogenetic manipulation NT their downstream connections modulates reward. Together, these data suggest previously rewarding targets possibly perceived as threats resulting from hyperactive occlude processing.

Language: Английский

Citations

100
Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective DOI Creative Commons
Alexandre Surget, Catherine Belzung

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 27(1), P. 403 - 421

Published: May 14, 2021

Abstract Adult hippocampal neurogenesis (AHN) represents a remarkable form of neuroplasticity that has increasingly been linked to the stress response in recent years. However, hippocampus does not itself support expression different dimensions response. Moreover, main functions are essentially preserved under AHN depletion and adult-born immature neurons (abGNs) have no extrahippocampal projections, which questions mechanisms by abGNs influence supported brain areas far from hippocampus. Within this framework, we propose through its computational influences is pivotal shaping adaption environmental demands, underlying role The with high input convergence output divergence hub, ideally positioned (1) detect cues contexts past, current predicted stressful experiences, (2) supervise at cognitive, affective, behavioral, physiological levels. appears bias computations toward enhanced conjunctive encoding pattern separation, promoting contextual discrimination cognitive flexibility, reducing proactive interference generalization experiences safe contexts. These effects result gating downstream more accurate contextualized information, enabling be appropriately set specific Here, first provide an integrative perspective functional involvement phenomenological overview We then examine mechanistic underpinning describe potential implications accompanying

Language: Английский

Citations

68
Dorsal periaqueductal gray ensembles represent approach and avoidance states DOI Creative Commons
Fernando MCV Reis, Johannes Y Lee, Sandra Maesta‐Pereira

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: May 6, 2021

Animals must balance needs to approach threats for risk assessment and avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how represents states associated with threat avoidance. We identified a dPAG threatavoidance ensemble in mice that showed higher activity farther from such as the open arms of elevated plus maze predator. These cells were also more active during avoidance behaviors escape freezing, even though these have antagonistic motor output. Conversely, was near threats. Furthermore, unsupervised methods avoidance/approach encoded shared patterns across Lastly, relative number each predicted mice. Thus, ensembles dynamically encode states, providing flexible mechanism danger

Language: Английский

Citations

66
Flexible inhibitory control of visually evoked defensive behavior by the ventral lateral geniculate nucleus DOI Creative Commons
Alex Fratzl, Alice M. Koltchev, Nicole Vissers

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(23), P. 3810 - 3822.e9

Published: Oct. 5, 2021

Animals can choose to act upon, or ignore, sensory stimuli, depending on circumstance and prior knowledge. This flexibility is thought depend neural inhibition, through suppression of inappropriate disinhibition appropriate actions. Here, we identified the ventral lateral geniculate nucleus (vLGN), an inhibitory prethalamic area, as a critical node for control visually evoked defensive responses in mice. The activity vLGN projections medial superior colliculus (mSC) modulated by previous experience threatening tracks perceived threat level environment, low escape from visual threat. Optogenetic stimulation abolishes responses, suppressing its lowers threshold increases risk-avoidance behavior. most strongly affects potentially via modality-specific inhibition mSC circuits. Thus, circuits behavior, animal's anticipation danger environment.

Language: Английский

Citations

61
Defensive responses: behaviour, the brain and the body DOI
Yu-Ting Tseng, Bernhard Schaefke, Pengfei Wei

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(11), P. 655 - 671

Published: Sept. 20, 2023

Language: Английский

Citations

35
5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice DOI
Sarah J. Jefferson, Ian Gregg, Mark Dibbs

et al.

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 48(9), P. 1257 - 1266

Published: April 4, 2023

Language: Английский

Citations

31
The functional and anatomical characterization of three spinal output pathways of the anterolateral tract DOI Creative Commons
Haichao Chen, Isabel H. Bleimeister, Eileen Nguyen

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(3), P. 113829 - 113829

Published: Feb. 28, 2024

The nature of spinal output pathways that convey nociceptive information to the brain has been subject controversy. Here, we provide anatomical, molecular, and functional characterizations two distinct anterolateral pathways: one, ascending in lateral cord, triggers behaviors, other ventral when inhibited, leads sensorimotor deficits. Moreover, pathway consists at least subtypes. first is a contralateral extends periaqueductal gray (PAG) thalamus; second bilateral projects parabrachial nucleus (PBN). Finally, present evidence showing activation sufficient for defensive behaviors such as running freezing, whereas attending licking guarding. This work offers insight into complex organizational logic system mouse.

Language: Английский

Citations

12
Behavioral and brain mechanisms mediating conditioned flight behavior in rats DOI Creative Commons
Michael S. Totty,

Naomi Warren,

Isabella Huddleston

et al.

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: April 15, 2021

Abstract Environmental contexts can inform animals of potential threats, though it is currently unknown how context biases the selection defensive behavior. Here we investigated context-dependent flight responses with a Pavlovian serial-compound stimulus (SCS) paradigm that evokes freeze-to-flight transitions. Similar to previous work in mice, show male and female rats display flight-like behavior SCS paradigm. Flight was dependent on contextual fear insofar as only evoked shock-associated reduced conditioning after extinction. expressed white noise regardless temporal order within compound. Nonetheless, received unpaired trials did not SCS, indicating associative. Finally, pharmacological inactivation two brain regions critical expression fear, central nucleus amygdala (CeA) bed stria terminalis (BNST), attenuates both responses. All these effects were similar rats. This demonstrates summate cued innate drive high state transition from post-encounter circa-strike modes.

Language: Английский

Citations

49