A C. elegans neuron both promotes and suppresses motor behavior to fine tune motor output DOI Creative Commons
Zhaoyu Li,

Jiejun Zhou,

Khursheed A. Wani

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Aug. 15, 2023

How neural circuits drive behavior is a central question in neuroscience. Proper execution of motor requires precise coordination many neurons. Within circuit, individual neurons tend to play discrete roles by promoting or suppressing output. exactly function specific fine tune output not well understood. In C. elegans , the interneuron RIM plays important yet complex locomotion behavior. Here, we show that both promotes and suppresses distinct features This dual achieved via excitation inhibition same circuit electrical chemical neurotransmission, respectively. Additionally, this bi-directional regulation contributes adaptation animals placed novel environments. Our findings reveal within may act opposing ways regulate dynamics behavioral

Language: Английский

Quantifying behavior to understand the brain DOI
Talmo Pereira, Joshua W. Shaevitz, Mala Murthy

et al.

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(12), P. 1537 - 1549

Published: Nov. 9, 2020

Language: Английский

Citations

256
Large-scale neural recordings call for new insights to link brain and behavior DOI
Anne E. Urai, Brent Doiron, Andrew M. Leifer

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(1), P. 11 - 19

Published: Jan. 1, 2022

Language: Английский

Citations

255
Hierarchical dynamics as a macroscopic organizing principle of the human brain DOI Open Access
Ryan V. Raut, Abraham Z. Snyder, Marcus E. Raichle

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(34), P. 20890 - 20897

Published: Aug. 12, 2020

Multimodal evidence suggests that brain regions accumulate information over timescales vary according to anatomical hierarchy. Thus, these experimentally defined "temporal receptive windows" are longest in cortical distant from sensory input. Interestingly, spontaneous activity also plays out relatively slow (i.e., exhibits slower temporal autocorrelation decay). These findings raise the possibility hierarchical represent an intrinsic organizing principle of function. Here, using resting-state functional MRI, we show timescale ongoing dynamics follows spatial gradients throughout human cerebral cortex. give rise systematic frequency differences among large-scale networks and predict individual-specific features connectivity. Whole-brain coverage permitted us further investigate organization subcortical dynamics. We topographically mirrored striatum, thalamus, cerebellum. Finally, hippocampus followed a posterior-to-anterior gradient, corresponding longitudinal axis increasing representational scale. emerge as global mammalian brains.

Language: Английский

Citations

219
NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans DOI Creative Commons
Eviatar Yemini, Albert Lin, Amin Nejatbakhsh

et al.

Cell, Journal Year: 2020, Volume and Issue: 184(1), P. 272 - 288.e11

Published: Dec. 29, 2020

Language: Английский

Citations

210
Neural circuit policies enabling auditable autonomy DOI
Mathias Lechner, Ramin Hasani,

Alexander Amini

et al.

Nature Machine Intelligence, Journal Year: 2020, Volume and Issue: 2(10), P. 642 - 652

Published: Oct. 13, 2020

Language: Английский

Citations

207
Intrinsic neural timescales: temporal integration and segregation DOI
Annemarie Wolff, Nareg Berberian, Mehrshad Golesorkhi

et al.

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 26(2), P. 159 - 173

Published: Jan. 3, 2022

Language: Английский

Citations

159
The brain and its time: intrinsic neural timescales are key for input processing DOI Creative Commons
Mehrshad Golesorkhi, Javier Gómez‐Pilar, Federico Zilio

et al.

Communications Biology, Journal Year: 2021, Volume and Issue: 4(1)

Published: Aug. 16, 2021

Abstract We process and integrate multiple timescales into one meaningful whole. Recent evidence suggests that the brain displays a complex multiscale temporal organization. Different regions exhibit different as described by concept of intrinsic neural (INT); however, their function mechanisms remains unclear. review recent literature on INT propose they are key for input processing. Specifically, shared across species, i.e., sharing. This role in encoding inputs through matching inputs’ stochastics with ongoing statistics brain’s activity, encoding. Following simulation empirical data, we point out integration versus segregation sampling deeply grounds within its environmental evolutionary context. It carries major implications understanding mental features psychiatric disorders, well going beyond integrating artificial intelligence.

Language: Английский

Citations

119
Interbrain synchrony: on wavy ground DOI
Clay B. Holroyd

Trends in Neurosciences, Journal Year: 2022, Volume and Issue: 45(5), P. 346 - 357

Published: Feb. 28, 2022

Language: Английский

Citations

81
Brain-wide representations of behavior spanning multiple timescales and states in C. elegans DOI Creative Commons

Adam A. Atanas,

Jung Soo Kim, Ziyu Wang

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(19), P. 4134 - 4151.e31

Published: Aug. 21, 2023

Changes in an animal's behavior and internal state are accompanied by widespread changes activity across its brain. However, how neurons the brain encode this is impacted poorly understood. We recorded brain-wide diverse motor programs of freely moving C. elegans built probabilistic models that explain each neuron encodes quantitative behavioral features. By determining identities neurons, we created atlas defined classes connectome behavior. Many have conjunctive representations multiple behaviors. Moreover, although many current actions, others integrate recent actions. behavior, identify these flexible nodes connectome. Our results provide a global map cell types

Language: Английский

Citations

47
Is depression a global brain disorder with topographic dynamic reorganization? DOI Creative Commons
Georg Northoff, Dušan Hirjak

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 5, 2024

Abstract Major depressive disorder (MDD) is characterized by a multitude of psychopathological symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal mechanisms underlying such co-occurrence remain yet unclear. Rather than linking localizing single to specific regions or networks, this perspective proposes more global dynamic topographic approach. We first review recent findings on brain activity changes during both rest task states in MDD showing reorganization with shift from unimodal transmodal regions. Next, we out two candidate that may underlie mediate abnormal uni-/transmodal topography, namely shifts shorter longer timescales abnormalities the excitation-inhibition balance. Finally, show how relates various their co-occurrence. This amounts what describe as ‘Topographic reorganization’ which extends our earlier ‘Resting state hypothesis depression’ complements other models MDD.

Language: Английский

Citations

17