Memory engrams: Recalling the past and imagining the future

Science, Journal Year: 2020, Volume and Issue: 367(6473)

Published: Jan. 3, 2020

In 1904, Richard Semon introduced the term "engram" to describe neural substrate for storing memories. An experience, proposed, activates a subset of cells that undergo off-line, persistent chemical and/or physical changes become an engram. Subsequent reactivation this engram induces memory retrieval. Although Semon's contributions were largely ignored in his lifetime, new technologies allow researchers image and manipulate brain at level individual neurons has reinvigorated research. We review recent progress studying engrams, including evaluation evidence existence importance intrinsic excitability synaptic plasticity lifetime Together, these findings are beginning define as basic unit memory.

Language: Английский

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The neurobiology of human fear generalization: meta-analysis and working neural model

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 128, P. 421 - 436

Published: July 6, 2021

Language: Английский

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Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(5), P. 630 - 645

Published: May 1, 2022

Language: Английский

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Hippocampal-amygdala memory circuits govern experience-dependent observational fear

Neuron, Journal Year: 2022, Volume and Issue: 110(8), P. 1416 - 1431.e13

Published: Feb. 8, 2022

The empathic ability to vicariously experience the other's fearful situation, a process called observational fear (OF), is critical survive in nature and function society. OF can be facilitated by both prior similar observer social familiarity with demonstrator. However, neural circuit mechanisms of experience-dependent (Exp OF) remain unknown. Here, we demonstrate that hippocampal-basolateral amygdala (HPC-BLA) circuits mice without involving anterior cingulate cortex, considered center OF, mediate Exp OF. Dorsal HPC neurons generate memory engram cells BLA encoding experiences, which are essential for On other hand, ventral respond familiar demonstrator's aversive situation during reactivates elicit Our study provides new insights into engram-dependent perception-action coupling underlies behaviors like

Language: Английский

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Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(8), P. 3207 - 3219

Published: June 27, 2023

Tremendous strides have been made in our understanding of the neurobiological substrates memory - so-called "engram". Here, we integrate recent progress engram field to illustrate how neurons transform across "lifespan" a from initial encoding, consolidation and retrieval, ultimately forgetting. To do so, first describe cell-intrinsic properties shape emergence at encoding. Second, highlight these encoding preferentially participate synaptic- systems-level memory. Third, changes during guide neural reactivation facilitate recall. Fourth, mechanisms forgetting, can counteract established consolidation, retrieval. Motivated by experimental results four sections, conclude proposing some conceptual extensions traditional view engram, including broadening cell-type participation within engrams stages. In collection, review synthesizes general principles stages, describes future avenues further understand dynamic engram.

Language: Английский

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Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 8, 2024

Abstract Compulsive behaviors are observed in a range of psychiatric disorders, however the neural substrates underlying not clearly defined. Here we show that basolateral amygdala-dorsomedial striatum (BLA-DMS) circuit activation leads to manifestation compulsive-like behaviors. We revealed BLA neurons projecting DMS, mainly onto dopamine D1 receptor-expressing neurons, largely overlap with neuronal population responds aversive predator stress, widely used anxiogenic stressor. Specific optogenetic BLA-DMS induced strong anxiety response followed by compulsive grooming. Furthermore, developed mouse model for compulsivity displaying wide spectrum chronically activating circuit. In these mice, persistent molecular changes at synapses were causally related phenotypes. Together, our study demonstrates involvement emergence enduring via its synaptic changes.

Language: Английский

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Intercalated amygdala clusters orchestrate a switch in fear state

Nature, Journal Year: 2021, Volume and Issue: 594(7863), P. 403 - 407

Published: May 26, 2021

Language: Английский

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Genetically identified amygdala–striatal circuits for valence-specific behaviors

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(11), P. 1586 - 1600

Published: Oct. 18, 2021

Language: Английский

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Synaptic correlates of associative fear memory in the lateral amygdala

Neuron, Journal Year: 2021, Volume and Issue: 109(17), P. 2717 - 2726.e3

Published: Aug. 6, 2021

Language: Английский

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A neuronal mechanism for motivational control of behavior

Science, Journal Year: 2022, Volume and Issue: 375(6576)

Published: Jan. 6, 2022

Acting to achieve goals depends on the ability motivate specific behaviors based their predicted consequences given an individual’s internal state. However, underlying neuronal mechanisms that encode and maintain such motivational control of behavior are poorly understood. Here, we used Ca2+ imaging optogenetic manipulations in basolateral amygdala freely moving mice performing noncued, self-paced instrumental goal-directed actions receive consume rewards. We found distinct activity patterns sequentially represent entire action-consumption behavioral sequence. Whereas action-associated integrated identity, value, expectancy pursued goals, consumption-associated reflected identity value experienced outcomes. Thus, interplay between these allows maintenance states necessary adaptively direct toward prospective

Language: Английский

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