Current Opinion in Biotechnology, Journal Year: 2021, Volume and Issue: 72, P. 54 - 61
Published: Oct. 26, 2021
Language: Английский
JASA Express Letters, Journal Year: 2022, Volume and Issue: 2(7)
Published: July 1, 2022
Cochlear implants have been the most successful neural prosthesis, with one million users globally. Researchers used source-filter model and speech vocoder to design modern multi-channel implants, allowing implantees achieve 70%–80% correct sentence recognition in quiet, on average. also cochlear implant help understand basic mechanisms underlying loudness, pitch, cortical plasticity. While front-end processing advances improved noise, unilateral quiet has plateaued since early 1990s. This lack of progress calls for action re-designing stimulating interface collaboration general neurotechnology community.
Language: Английский
Citations
94
Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(8), P. 4693 - 4763
Published: Feb. 8, 2023
Fibers, originating from nature and mastered by human, have woven their way throughout the entire history of human civilization. Recent developments in semiconducting polymer materials further endowed fibers textiles with various electronic functions, which are attractive applications such as information interfacing, personalized medicine, clean energy. Owing to ability be easily integrated into daily life, soft fiber electronics based on polymers gained popularity recently for wearable implantable applications. Herein, we present a review previous current progress polymer-based electronics, particularly focusing smart-wearable areas. First, provide brief overview viewpoint basic concepts functionality requirements different devices. Then analyze existing associated devices interfaces, healthcare energy conversion storage. The working principle performance summarized. Furthermore, focus fabrication techniques Based continuous one-dimensional yarn, introduce two- three-dimensional fabric fabricating methods. Finally, challenges relevant perspectives potential solutions address related problems.
Language: Английский
Citations
85
Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(7), P. 541 - 558
Published: April 15, 2024
Language: Английский
Citations
77
Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)
Published: Jan. 5, 2023
Abstract Implantable intracortical microelectrodes can record a neuron’s rapidly changing action potentials (spikes). In vivo neural activity recording methods often have either high temporal or spatial resolution, but not both. There is an increasing need to more neurons over longer duration in vivo. However, there remain many challenges overcome before achieving long-term, stable, high-quality recordings and realizing comprehensive, accurate brain analysis. Based on the vision of idealized implantable microelectrode device, performance requirements for are divided into four aspects, including quality, stability, throughput, multifunctionality, which presented order importance. The current possible solutions given from perspective each aspect. developments technology analyzed summarized.
Language: Английский
Citations
55
Science, Journal Year: 2023, Volume and Issue: 381(6655), P. 306 - 312
Published: July 20, 2023
Implantable neuroelectronic interfaces have enabled advances in both fundamental research and treatment of neurological diseases but traditional intracranial depth electrodes require invasive surgery to place can disrupt neural networks during implantation. We developed an ultrasmall flexible endovascular probe that be implanted into sub-100-micrometer-scale blood vessels the brains rodents without damaging brain or vasculature. In vivo electrophysiology recording local field potentials single-unit spikes been selectively achieved cortex olfactory bulb. Histology analysis tissue interface showed minimal immune response long-term stability. This platform technology readily extended as tools medical devices for detection intervention diseases.
Language: Английский
Citations
51
Cell Reports, Journal Year: 2023, Volume and Issue: 42(6), P. 112554 - 112554
Published: May 24, 2023
Intracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation are often compromised by adverse tissue responses indwelling electrodes. Here we engineer ultraflexible stim-nanoelectronic threads (StimNETs) demonstrate low activation threshold, high chronically stable ICMS in awake, behaving mouse models. In vivo two-photon imaging reveals that StimNETs remain seamlessly integrated with nervous throughout stimulation periods elicit stable, focal neuronal at currents 2 μA. Importantly, evoke longitudinally behavioral for over 8 months a markedly charge injection 0.25 nC/phase. Quantified histological analyses show induces no degeneration or glial scarring. These results suggest tissue-integrated electrodes provide path robust, long-lasting, spatially selective currents, which lessens risk damage exacerbation off-target side effects.
Language: Английский
Citations
43
Current Opinion in Biotechnology, Journal Year: 2021, Volume and Issue: 72, P. 102 - 111
Published: Nov. 5, 2021
Implantable brain machine interfaces (BMIs) are now on a trajectory to go mainstream, wherein what was once considered last resort will progressively become elective at earlier stages in disease treatment. First-in-human successes have demonstrated the ability decode highly dexterous motor skills such as handwriting, and speech from human cortical activity. These been used for cursor prosthesis control, direct-to-text communication synthesis. Along with these breakthrough studies, technology advancements enabled observation of more channels neural activity through new concepts centralised/distributed implant architectures. This is complemented by research flexible substrates, packaging, surgical workflows data processing. New regulatory guidance funding has galvanised field. culmination resource, efforts capability attracting significant investment BMI commercialisation. paper reviews recent developments describes paradigm shift development that leading innovations, insights translation.
Language: Английский
Citations
81
Advanced Energy Materials, Journal Year: 2022, Volume and Issue: 12(13)
Published: Feb. 9, 2022
Abstract Advances in microelectronics have enabled the use of miniaturized computers for autonomous intelligence at size a dust particle less than one square millimeter across and few hundred micrometers thick, creating an environment ubiquitous computing. However, mismatch between microbatteries has emerged as fundamental barrier against take‐off tiny intelligent systems requiring power anytime anywhere. Mainstream microbattery structures include stacked thin films on chip or electrode pillars on‐chip interdigitated microelectrodes. Nevertheless, available technologies cannot shrink footprint area batteries while maintaining adequate energy storage. Alternatively, self‐assembly process known micro‐origami is capable winding into Swiss‐roll to reduce area, which exactly mimics manufacture most successful full‐sized batteries—cylinder batteries. In addition discussing detail technical difficulties reducing with various potential solutions, this Perspective highlights following two basic requirements eventual integration microcomputers: minimum density 100 microwatt‐hour per centimeter monolithic other functional electric circuits chip.
Language: Английский
Citations
59
Advanced Materials, Journal Year: 2022, Volume and Issue: 34(45)
Published: Aug. 4, 2022
Abstract Requirements and recent advances in research on organic neuroelectronics are outlined herein. Neuroelectronics such as neural interfaces neuroprosthetics provide a promising approach to diagnose treat neurological diseases. However, the current rigid not biocompatible, so they induce an immune response deterioration of signal transmission. Organic materials candidates for interfaces, due their mechanical softness, excellent electrochemical properties, biocompatibility. Also, nervetronics, which mimics functional properties biological nerve system, is being developed overcome limitations complex energy‐consuming conventional that limit long‐term implantation daily‐life usage. Examples recordings reviewed, nervetronics use artificial synapses highlighted, then further requirements discussed. Finally, future challenges must be achieve ideal next‐generation
Language: Английский
Citations
56
Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 100 - 100
Published: Feb. 10, 2025
Understanding brain function requires advanced neural probes to monitor electrical and chemical signaling across multiple timescales regions. Microelectrode arrays (MEAs) are widely used record neurophysiological activity various depths regions, providing single-unit resolution for extended periods. Recent advancements in flexible MEAs, built on micrometer-thick polymer substrates, have improved integration with tissue by mimicking the brain's soft nature, reducing mechanical trauma inflammation. These flexible, subcellular-scale MEAs can stable signals months, making them ideal long-term studies. In addition recording, been functionalized electrochemical neurotransmitter detection. Electroactive neurotransmitters, such as dopamine, serotonin, adenosine, be directly measured via methods, particularly carbon-based surfaces. For non-electroactive neurotransmitters like acetylcholine, glutamate, γ-aminobutyric acid, alternative strategies, enzyme immobilization aptamer-based recognition, employed generate signals. This review highlights recent developments MEA fabrication functionalization achieve both electrophysiological recordings, minimizing sensor fowling damage when implanted long-term. It covers multi-time scale detection, development of conducting nanomaterial composite coatings enhance sensitivity, incorporation recognition carbon electrodes MEAs. Finally, it summarizes strategies acquire measurements from same device.
Language: Английский
Citations
1