Neural codes in early sensory areas maximize fitness DOI Creative Commons

Jonathan Schaffner,

Philippe N. Tobler, Todd A. Hare

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: May 11, 2021

It has generally been presumed that sensory information encoded by a nervous system should be as accurate its biological limitations allow. However, perhaps counter intuitively, representations of signals do not necessarily maximize the organism’s chances survival. To test this hypothesis, we developed unified normative framework for fitness-maximizing encoding combining theoretical insights from neuroscience, computer science, and economics. Initially, applied predictions model to neural responses large monopolar cells (LMCs) in blowfly retina. We found codes reward expectation—and representations—account retinal LMC activity. also conducted experiments humans find early areas flexibly adopt promote fitness maximization retinotopically-specific manner, which impacted decision behavior. Thus, our results provide evidence rules imposed environment are at earliest stages processing.

Language: Английский

Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective DOI Creative Commons
Ileana L. Hanganu‐Opatz, Thomas Klausberger, Torfi Sigurdsson

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1020 - 1036

Published: April 1, 2023

Language: Английский

Citations

51
Top-down input modulates visual context processing through an interneuron-specific circuit DOI Creative Commons

Georgia Bastos,

Jacob T. Holmes,

Jordan M. Ross

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(9), P. 113133 - 113133

Published: Sept. 1, 2023

Visual stimuli that deviate from the current context elicit augmented responses in primary visual cortex (V1). These heightened responses, known as "deviance detection," require local inhibition V1 and top-down input anterior cingulate area (ACa). Here, we investigated mechanisms by which ACa interact to support deviance detection. Local field potential recordings mice during an oddball paradigm showed ACa-V1 synchrony peaks theta/alpha band (≈10 Hz). Two-photon imaging revealed mainly pyramidal neurons exhibited detection, while contextually redundant increased vasoactive intestinal peptide (VIP)-positive interneuron (VIP) activity decreased somatostatin-positive (SST) activity. Optogenetic drive of inputs at 10 Hz activated V1-VIPs but inhibited V1-SSTs, mirroring dynamics present paradigm. Chemogenetic disrupted Aca-V1 detection V1. results outline temporal interneuron-specific modulation processing.

Language: Английский

Citations

25
Behavior-relevant top-down cross-modal predictions in mouse neocortex DOI
Shuting Han, Fritjof Helmchen

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(2), P. 298 - 308

Published: Jan. 4, 2024

Language: Английский

Citations

12
Cortical-subcortical interactions in goal-directed behavior DOI
K. Guadalupe Cruz,

Yi Ning Leow,

Nhat Minh Le

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(1), P. 347 - 389

Published: June 30, 2022

Flexibly selecting appropriate actions in response to complex, ever-changing environments requires both cortical and subcortical regions, which are typically described as participating a strict hierarchy. In this traditional view, highly specialized circuits allow for efficient responses salient stimuli, at the cost of adaptability context specificity, attributed neocortex. Their interactions often cortex providing top-down command signals structures implement; however, available technologies develop, studies increasingly demonstrate that behavior is represented by brainwide activity even contain early choice, suggesting behavioral functions emerge result different regions interacting truly collaborative networks. review, we discuss field’s evolving understanding how placental mammals interact cooperatively, not only via cortical-subcortical inputs but through bottom-up interactions, especially thalamus. We describe our current circuitry two exemplar structures, superior colliculus striatum, identify information prioritized regions. then functional these form with one another, thalamus, create parallel loops complex networks flow. Finally, challenge classic view modules contained within specific brain regions; instead, propose certain prioritize types over others, subnetworks they form, defined their anatomical connections dynamics, basis true specialization.

Language: Английский

Citations

32
Sensory perception relies on fitness-maximizing codes DOI Creative Commons

Jonathan Schaffner,

Sherry Dongqi Bao, Philippe N. Tobler

et al.

Nature Human Behaviour, Journal Year: 2023, Volume and Issue: 7(7), P. 1135 - 1151

Published: April 27, 2023

Abstract Sensory information encoded by humans and other organisms is generally presumed to be as accurate their biological limitations allow. However, perhaps counterintuitively, sensory representations may not necessarily maximize the organism’s chances of survival. To test this hypothesis, we developed a unified normative framework for fitness-maximizing encoding combining theoretical insights from neuroscience, computer science, economics. Behavioural experiments in revealed that strategies are flexibly adapted promote fitness maximization, result confirmed deep neural networks with capacity constraints trained solve same task humans. Moreover, human functional MRI data novel behavioural goals rely on object perception induce efficient stimulus early structures. These results suggest rules imposed environment applied at stages processing machines.

Language: Английский

Citations

23
Informing deep neural networks by multiscale principles of neuromodulatory systems DOI
Jie Mei, Eilif Müller, Srikanth Ramaswamy

et al.

Trends in Neurosciences, Journal Year: 2022, Volume and Issue: 45(3), P. 237 - 250

Published: Jan. 21, 2022

Language: Английский

Citations

28
Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus DOI Creative Commons
Amanda B. Leithead, Arthur Godino, Marie Barbier

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(2), P. 112 - 122

Published: May 27, 2023

BackgroundThe posterior intralaminar (PIL) complex of the thalamus is a multimodal nucleus that has been implicated in maternal behaviors and conspecific social male female rodents. Glutamatergic neurons are major component PIL; however, their specific activity role during interactions not yet assessed.MethodsWe used immunohistochemistry for immediate early gene c-fos as proxy neuronal PIL mice exposed to novel stimulus, object or no stimulus. We then fiber photometry record neural glutamatergic real-time non-social interactions. Finally, we inhibitory DREADDs tested preference habituation-dishabituation.ResultsWe observed significantly more c-fos-positive cells versus stimuli. Neural was increased when were engaged interaction with same-sex juvenile opposite-sex adult, but toy mouse. positively correlated investigation bout length negatively chronological order bouts. Social unaffected by inhibition; inhibiting delayed time it took form habituation.ConclusionsTogether these findings suggest respond stimuli both may regulate perceptual encoding information facilitate recognition

Language: Английский

Citations

15
Layer 1 neocortex: Gating and integrating multidimensional signals DOI Creative Commons
Shuhan Huang, Jingjing Sherry Wu, Giulia Sansone

et al.

Neuron, Journal Year: 2023, Volume and Issue: 112(2), P. 184 - 200

Published: Oct. 31, 2023

Language: Английский

Citations

15
Control of sustained attention and impulsivity by Gq-protein signalling in parvalbumin interneurons of the anterior cingulate cortex DOI Creative Commons

Martin M. Jendryka,

Uwe Lewin,

Bastiaan van der Veen

et al.

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 5, 2023

Abstract The anterior cingulate cortex (ACC) has been implicated in attention deficit hyperactivity disorder (ADHD). More specifically, an appropriate balance of excitatory and inhibitory activity the ACC may be critical for control impulsivity, hyperactivity, sustained which are centrally affected ADHD. Hence, pharmacological augmentation parvalbumin- (PV) or somatostatin-positive (Sst) interneurons could a potential treatment strategy. We, therefore, tested whether stimulation G q -protein-coupled receptors (G PCRs) these improve impulsivity assessed with 5-choice-serial reaction-time task male mice. When challenging impulse behaviourally pharmacologically, activation chemogenetic PCR hM3Dq PV-cells caused selective decrease active erroneous—i.e. incorrect premature—responses, indicating improved attentional control. attention, contrast, omissions were increased, albeit without extension reward latencies decreases accuracy. These effects largely resembled those ADHD medication atomoxetine. Additionally, they mostly independent each other within individual animals. also reduced hyperactivity. In if was activated Sst-interneurons, no improvement observed, reduction responses only induced at high agonist levels accompanied by motivational drive. results suggest that PCRs expressed specifically viable strategy to certain aspects

Language: Английский

Citations

14
Common and distinct neural mechanisms of attention DOI Creative Commons
Ruobing Xia, Xiaomo Chen, Tatiana A. Engel

et al.

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(6), P. 554 - 567

Published: Feb. 22, 2024

Language: Английский

Citations

6