A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 12, 2022

Abstract Decades of rodent research have established the role hippocampal sharp wave ripples (SPW-Rs) in consolidating and guiding experience. More recently, intracranial recordings humans suggested their episodic semantic memory. Yet, common standards for recording, detection, reporting do not exist. Here, we outline methodological challenges involved detecting ripple events offer practical recommendations to improve separation from other high-frequency oscillations. We argue that shared experimental, will provide a solid foundation future translational discovery.

Language: Английский

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The Neuropsychology of Anxiety

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Language: Английский

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Brain-wide interactions during hippocampal sharp wave ripples

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(20)

Published: May 13, 2022

Significance Bidirectional communication between the hippocampus and other brain areas via sharp wave ripples (SPW-Rs) has been hypothesized to play an important role in cognitive functions. However, brain-wide coupling SPW-Rs difficult study at high temporal spatial resolution. Here, we show that coincide with transient increase of functional connectivity. The diversity SPW-R features was related slower excitability fluctuations cortical subcortical areas. In return, correlated timing, sign, magnitude partner structure responses. Our findings provide most extensive survey spiking activity surrounding hippocampal date.

Language: Английский

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The human brain reactivates context-specific past information at event boundaries of naturalistic experiences

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(6), P. 1080 - 1089

Published: May 29, 2023

Language: Английский

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Consciousness and sleep

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1568 - 1594

Published: May 1, 2024

Language: Английский

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Coupled sleep rhythms for memory consolidation

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(4), P. 339 - 351

Published: March 4, 2024

How do passing moments turn into lasting memories? Sheltered from external tasks and distractions, sleep constitutes an optimal state for the brain to reprocess consolidate previous experiences. Recent work suggests that consolidation is governed by intricate interaction of slow oscillations (SOs), spindles, ripples – electrophysiological rhythms orchestrate neuronal processing communication within across memory circuits. This review describes how sequential SO–spindle–ripple coupling provides a temporally spatially fine-tuned mechanism selectively strengthen target memories hippocampal cortical networks. Coupled might be harnessed not only enhance overnight retention, but also combat decline associated with healthy ageing neurodegenerative diseases.

Language: Английский

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A generative model of memory construction and consolidation

Nature Human Behaviour, Journal Year: 2024, Volume and Issue: 8(3), P. 526 - 543

Published: Jan. 19, 2024

Abstract Episodic memories are (re)constructed, share neural substrates with imagination, combine unique features schema-based predictions and show distortions that increase consolidation. Here we present a computational model in which hippocampal replay (from an autoassociative network) trains generative models (variational autoencoders) to (re)create sensory experiences from latent variable representations entorhinal, medial prefrontal anterolateral temporal cortices via the formation. Simulations effects of memory age lesions agreement previous models, but also provide mechanisms for semantic memory, episodic future thinking, relational inference including boundary extension. The explains how predictable conceptual elements stored reconstructed by efficiently combining both neocortical systems, optimizing use limited storage new unusual information. Overall, believe training provides comprehensive account construction, imagination

Language: Английский

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Neural and behavioural state switching during hippocampal dentate spikes

Nature, Journal Year: 2024, Volume and Issue: 628(8008), P. 590 - 595

Published: March 13, 2024

Abstract Distinct brain and behavioural states are associated with organized neural population dynamics that thought to serve specific cognitive functions 1–3 . Memory replay events, for example, occur during synchronous events called sharp-wave ripples in the hippocampus while mice an ‘offline’ state, enabling mechanisms such as memory consolidation planning 4–11 But how does re-engage external world this state permit access current sensory information or promote new formation? Here we found hippocampal dentate spike, understudied event frequently occurs between 12 , may underlie a mechanism. We show spikes distinctly elevated brain-wide firing rates, primarily observed higher order networks, couple brief periods of arousal. Hippocampal place coding aligns mouse’s spatial location, unlike accompanying ripples. Furthermore, inhibiting activity disrupts associative formation. Thus, represent distinct support non-locomotor behaviour, extending repertoire processes beyond classical offline functions.

Language: Английский

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Causal evidence for the processing of bodily self in the anterior precuneus

Neuron, Journal Year: 2023, Volume and Issue: 111(16), P. 2502 - 2512.e4

Published: June 8, 2023

Language: Английский

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A shared novelty-seeking basis for creativity and curiosity

Behavioral and Brain Sciences, Journal Year: 2023, Volume and Issue: 47

Published: Aug. 7, 2023

Abstract Curiosity and creativity are central pillars of human growth invention. Although they have been studied extensively in isolation, the relationship between them has not yet established. We propose that both curiosity emanate from same mechanism novelty seeking. first present a synthesis showing affected similarly by number key cognitive faculties such as memory, control, attention, reward. then review empirical evidence neuroscience research, indicating brain regions involved creativity, focusing on interplay three major networks: default mode network, salience executive control network. After substantiating link we novelty-seeking model (NSM) underlies suggests manifestation NSM is governed one's state mind.

Language: Английский

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