Dissociable roles of the mPFC-to-VTA Pathway in the control of iImpulsive Action and Risk-Related Decision-Making in Roman High- And Low-Avoidance Rats DOI Open Access
Ginna Urueña‐Méndez, Chloé Arrondeau,

Florian Marchessaux

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 14, 2024

Abstract Impulsivity is a multidimensional trait associated with various psychiatric disorders including drug abuse. facets, such as impulsive action and risk-related decision-making (RDM), have been reduced frontocortical activity alterations in dopamine function the ventral tegmental area (VTA). However, despite direct projections from medial prefrontal cortex (mPFC) to VTA, specific role of mPFC-to-VTA pathway control behaviors remains unexplored. Here, we used Positron Emission Tomography [ 18 F]-Fluorodeoxyglucose evaluate brain metabolic Roman High-(RHA) Low-avoidance (RLA) rats, which exhibit innate differences impulsivity. Notably, viral-based intersectional chemogenetic strategy isolate, for first time, controlling behaviors. We selectively activated RHAs inhibited it RLAs, assessed effects on RDM rat gambling task. Our results showed that RHA rats displayed higher action, less optimal decision-making, lower cortical than RLA at baseline. Chemogenetic activation RHAs, whereas inhibition had opposite effect RLAs. these manipulations did not affect RDM. Thus, by specifically bidirectionally targeting phenotype-dependent way, were able revert patterns but findings suggest dissociable RDM, highlighting its potential target investigating impulsivity-related disorders.

Language: Английский

Oxytocin receptor controls promiscuity and development in prairie voles DOI Open Access
Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt

et al.

Published: Feb. 14, 2025

Oxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including monogamy prairie voles. How Oxtr regulates specific components of attachment and the neural mechanisms mediating them remains unknown. Here, we examine voles lacking demonstrate that pair bonding comprises distinct behavioral modules: preference for a bonded partner, rejection novel potential mates. Our longitudinal study shows sex-specifically early interactions between partners facilitating formation partner preference. Additionally, suppresses promiscuity towards mates following bonding, contributing to rejection. function coordinated patterns gene expression regions implicated oxytocin paraventricular nucleus hypothalamus, principal source oxytocin. Thus, controls genetically separable coordinates development substrates attachment.

Language: Английский

Citations

1
Prefrontal Regulation of Social Behavior and Related Deficits: Insights From Rodent Studies DOI
Nancy R. Mack,

Nadia N. Bouras,

Wen‐Jun Gao

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(2), P. 85 - 94

Published: March 13, 2024

Language: Английский

Citations

8
Opposing and segregated cortical circuits control winning and losing behaviors DOI

Elizabeth Illescas-Huerta,

Nancy Padilla-Coreano

Neuron, Journal Year: 2025, Volume and Issue: 113(3), P. 335 - 336

Published: Feb. 1, 2025

Language: Английский

Citations

0
Oxytocin receptor controls promiscuity and development in prairie voles DOI Open Access
Ruchira Sharma, Kristen M. Berendzen, Amanda Everitt

et al.

Published: Feb. 14, 2025

Oxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including monogamy prairie voles. How Oxtr regulates specific components of attachment and the neural mechanisms mediating them remains unknown. Here, we examine voles lacking demonstrate that pair bonding comprises distinct behavioral modules: preference for a bonded partner, rejection novel potential mates. Our longitudinal study shows sex-specifically early interactions between partners facilitating formation partner preference. Additionally, suppresses promiscuity towards mates following bonding, contributing to rejection. function coordinated patterns gene expression regions implicated oxytocin paraventricular nucleus hypothalamus, principal source oxytocin. Thus, controls genetically separable coordinates development substrates attachment.

Language: Английский

Citations

0
Perturbations in the microbiota-gut-brain axis shaped by social status loss DOI Creative Commons

Ruijing Yang,

Xin Wang,

Jie Yang

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: March 8, 2025

Abstract Social status is closely linked to physiological and psychological states. Loss of social dominance can lead brain disorders such as depression, but the underlying mechanisms remain unclear. The gut microbiota sense stress contribute via microbiota-gut-brain axis (MGBA). Here, using a forced loss paradigm demote dominant mice subordinate ranks, we find that alters composition function microbiota, increasing Muribaculaceae abundance enhancing butanoate metabolism, microbial depletion resists loss-induced hierarchical demotion behavioral alteration. Single-nucleus transcriptomic analysis prefrontal cortex (PFC) indicates primarily affected interneurons, altering GABAergic synaptic transmission. Weighted gene co-expression network (WGCNA) reveals modules in colon, PFC, PFC suggesting changes PI3K-Akt signaling pathway glutamatergic synapse. Our findings provide evidence for MGBA perturbations induced by loss, offering potential intervention targets related disorders.

Language: Английский

Citations

0
Deconstructing the neural circuit underlying social hierarchy in mice DOI

Qiuhong Xin,

Diyang Zheng,

Tingting Zhou

et al.

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

3
Functional brain network dynamics mediate the relationship between female reproductive aging and interpersonal adversity DOI Creative Commons
Raluca Petrican, Sidhant Chopra, Ashlea Segal

et al.

Nature Mental Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Premature reproductive aging is linked to heightened stress sensitivity and psychological maladjustment across the life course. However, brain dynamics underlying this relationship are poorly understood. Here, address issue, we analyzed multimodal data from female participants in Adolescent Brain Cognitive Development (longitudinal, N = 441; aged 9–12 years) Human Connectome-Aging (cross-sectional, 130; 36–60 studies. Age-specific intrinsic functional network mediated link between perceptions of greater interpersonal adversity. The adolescent profile overlapped areas glutamatergic dopaminergic receptor density, middle-aged was concentrated visual, attentional default mode networks. two profiles showed opposite relationships with patterns neural variability cortical atrophy observed psychosis versus major depressive disorder. Our findings underscore divergent maturation senescence, which may explain developmentally specific vulnerabilities distinct disorders.

Language: Английский

Citations

0
Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top–Down Circuit DOI Creative Commons
Jingwei Zhou, Zhaoyang Yin, Zhiyun Chen

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Social novelty is indispensable for a wide range of social behaviors. The medial prefrontal cortex (mPFC), along with other information hubs, composes the foundational circuitry novelty. However, precise circuit mechanisms that govern processing remain elusive. piriform cortex, as largest olfactory receives extensive innervation from top‐down centers dictate behavior. Here, it shown anterior (APC) exhibited an increase in gamma event incidence during engagement male mice. In vivo electrophysiology and fiber photometry reveal APC pyramidal neurons respond more intensely to novel mice than familiar ones. Intriguingly, silencing selectively impairs processing, yet leaves basic discrimination capabilities intact. Moreover, inherits cues mPFC sends feedback projections bulb (OB) modulate These findings unveil APC's role extending well beyond olfaction, encompassing specialized function recognition

Language: Английский

Citations

0
Reevaluating the Role of Pou3f1 in Striatal Development: Evidence from Transgenic Mouse Models DOI Creative Commons
Xiaolei Song, Fanshi Zhang, D. K. Han

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111302 - 111302

Published: March 1, 2025

Language: Английский

Citations

0
Social hierarchy modulates drug reinforcement and protein phosphorylation in the nucleus accumbens DOI Creative Commons
Liang Xu, Rui Zhou,

Jiafeng Zhong

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 11, 2025

Introduction Drug reinforcement, a form of behavioral plasticity in which changes happen response to reinforcing drug, would finally lead drug addiction after chronical exposure. reinforcement is affected by genetic and environmental factors. Social hierarchy has been reported regulate drug-seeking behaviors, but the underlying molecular mechanism almost unknown. Methods We take advantage tube test assess social between two co-housed rats. And then, we investigated dominant subordinate rats via conditioned place preference (CPP). Then adopted 4-D label-free mass spectrometry explore complex phosphoproteome nucleus accumbens (NAc) Functional enrichment, protein-protein, motif analysis kinase prediction interaction were used investigate substance use disorder hierarchy. Specifically, identified histone deacetylase 4 (HDAC4) previously shown play critical roles as key node protein phosbind-SDS. Finally, forcibly altered through training, follow accessed HDAC4 phosphorylation levels reinforcement. Results In this study, found that methamphetamine exhibited stronger 660 sites differing spectrometry. enrichment protein-protein revealed synaptic remodeling related pathways pathway are significantly characterized Motif showed CaMKIIδ its downstream proteins maybe central hub. Phosbind-SDS higher dominants. After differences induced eliminated, correspondingly also reversed group Discussion conclusion, our research proves NAc may be vital link

Language: Английский

Citations

0