Mega-scale movie-fields in the mouse visuo-hippocampal network DOI Creative Commons

Chinmay S. Purandare,

Mayank Mehta

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Dec. 7, 2022

Abstract Natural experience often involves a continuous series of related images while the subject is immobile. How does cortico-hippocampal circuit process this information? The hippocampus crucial for episodic memory 1–3 , but most rodent single unit studies require spatial exploration 4–6 or active engagement 7 . Hence, we investigated neural responses to silent, isoluminant, black and white movie in head-fixed mice without any task locomotion demands, rewards, from Allen Brain Observatory. activity neurons (97%, 6554/6785) thalamo-cortical visual areas was significantly modulated by 30s long clip. Surprisingly, third (33%, 3379/10263) hippocampal –dentate gyrus, CA1 subiculum– showed movie-selectivity, with elevated firing specific sub-segments, termed movie-fields. Movie-tuning remained intact when were immobile ran spontaneously. On average, tuned cell had more than 5 movie-fields areas, only 2 areas. movie-field durations all brain regions spanned an unprecedented 1000-fold range: 0.02s 20s, mega-scale coding. Yet, total duration comparable across regions. We hypothesize that show greater continuous-sequence encoding as evidenced fewer broader Consistent hypothesis, repeated presentation fixed, scrambled sequence virtually abolished not visual-cortical selectivity. enhancement tuning compared eight-fold further supporting episodic-sequence encoding. Thus, mouse-brain encoded segments movie. Similar results are likely hold primates humans. movies could provide unified way probe mechanisms information processing memory, even subjects, regions, species.

Language: Английский

Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age DOI Creative Commons
Arne D. Ekstrom, Paul F. Hill

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1037 - 1049

Published: April 1, 2023

Language: Английский

Citations

44
From cognitive maps to spatial schemas DOI
Delaram Farzanfar, Hugo J. Spiers, Morris Moscovitch

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 24(2), P. 63 - 79

Published: Nov. 21, 2022

Language: Английский

Citations

68
Age differences in spatial memory are mitigated during naturalistic navigation DOI Creative Commons
Paul F. Hill,

Skyelynn Bermudez,

Andrew S. McAvan

et al.

Aging Neuropsychology and Cognition, Journal Year: 2024, Volume and Issue: 31(6), P. 1106 - 1130

Published: March 6, 2024

Spatial navigation deficits are often observed among older adults on tasks that require navigating virtual reality (VR) environments a computer screen. We investigated whether these age differences attenuated when tested in more naturalistic and ambulatory environments. In Experiment 1, young navigated variant of the Morris Water Maze task each two VR conditions: desktop condition which required using mouse keyboard to navigate, an permitted unrestricted locomotion. 2, we examined age- VR-related spatial performance were affected by inclusion additional cues. both experiments, target locations less precisely than younger individuals condition. Age significantly attenuated, however, environment. These findings underscore importance developing assessments memory navigation.

Language: Английский

Citations

7
What about “space” is important for episodic memory? DOI Creative Commons
Carina L. Fan, H. Moriah Sokolowski, R. Shayna Rosenbaum

et al.

Wiley Interdisciplinary Reviews Cognitive Science, Journal Year: 2023, Volume and Issue: 14(3)

Published: Feb. 11, 2023

Abstract Early cognitive neuroscientific research revealed that the hippocampus is crucial for spatial navigation in rodents, and autobiographical episodic memory humans. Researchers quickly linked these streams to propose human supports through its role representing space, on link between cognition humans has proliferated over past several decades. Different researchers apply term “spatial” a variety of contexts, however, it remains unclear what aspect space may be critical memory. Similarly, “episodic” been defined tested different ways. Naturalistic assessment (i.e., memory) required unify scale biological relevance comparisons mnemonic processing. Limitations regarding translation rodent research, ontogeny, inter‐individual variability require greater consideration interpretation this literature. In review, we outline aspects are (and not) commonly memory, then discuss dimensions lens individual differences naturalistic Future studies should carefully consider which aspect(s) being within context cognition. This article categorized under: Psychology > Memory

Language: Английский

Citations

13
Multisensory input modulates memory-guided spatial navigation in humans DOI Creative Commons
Deetje Iggena,

Sein Jeung,

Patrizia M. Maier

et al.

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: Nov. 14, 2023

Efficient navigation is supported by a cognitive map of space. The hippocampus plays key role for this linking multimodal sensory information with spatial memory representations. However, in human studies, the full range often unavailable due to stationarity experimental setups. We investigated contribution multisensory memory-guided presenting virtual version Morris water maze on screen and an immersive mobile reality setup. Patients hippocampal lesions matched controls navigated memorized object locations relation surrounding landmarks. Our results show that availability input improves both groups. It has distinct effects navigational behaviour, greater improvement performance patients. conclude congruent shifts computations extrahippocampal areas support compensates deficits.

Language: Английский

Citations

12
A Cognitive-Motor Framework for Spatial Navigation in Aging and Early-Stage Alzheimer’s Disease DOI
Paul F. Hill, Arne D. Ekstrom

Cortex, Journal Year: 2025, Volume and Issue: 185, P. 133 - 150

Published: Feb. 21, 2025

Language: Английский

Citations

0
Combining patient-lesion and big data approaches to reveal hippocampal contributions to spatial memory and navigation DOI Creative Commons
Sara Pishdadian, Antoine Coutrot,

Lauren Webber

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109977 - 109977

Published: May 14, 2024

Language: Английский

Citations

2
Translating spatial navigation evaluation from experimental to clinical settings: The virtual environments navigation assessment (VIENNA) DOI Creative Commons
Sophia Rekers, Carsten Finke

Behavior Research Methods, Journal Year: 2023, Volume and Issue: 56(3), P. 2033 - 2048

Published: May 11, 2023

Spatial navigation abilities are frequently impaired in neurological disorders and they also decline with normal aging. Researchers clinicians therefore need valid easy-to-use spatial assessment tools to study the impact of different neuropathologies prevent relevant cognitive impairments from going undetected. However, current experimental paradigms rarely address which processes recruit, often have resource-intensive setups, usually require active navigation, e.g., using a joystick or keyboard, thus confounding performance fine motor skills. Yet, for clinical feasibility, time-efficient needed that informative easy administer participants limited technical experience diverging impairments. Here, we introduce virtual environments (VIENNA), adaptation brief, standardized, intuitive paradigm ( https://osf.io/kp4c5/ ). VIENNA is designed assess without episodic memory demands, requires no interface device, takes about 16 min complete. We evaluated 79 healthy middle-aged older (50-85 years) provide evidence its feasibility construct validity. Tests visuospatial executive functions, but not selective attention, were identified as correlates VIENNA, even when controlling participant age overall performance. Furthermore, scores correlated subjective ability age, depressiveness, complaints, education. The straightforward administration allows integration into routine neuropsychological assessments enables differentiated evaluation patients deficits.

Language: Английский

Citations

5
Spatial dissociation between recognition and navigation in the primate hippocampus DOI Creative Commons
Xiao Mei Xu, Kechen Du, Dun Mao

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(38)

Published: Sept. 18, 2024

The primate hippocampus, crucial for both episodic memory and spatial navigation, remains an enigma regarding whether these functions share the same neural substrates. We investigated how identical hippocampal neurons in macaque monkeys dynamically shifted their representations between tasks. In a recognition task, notable fraction of showed that rate modulation strongly correlated with performance. During free navigation open arena, view, rather than position, predominantly influenced selectivity neurons. Neurons selective displayed minimal tuning, while spatially tuned exhibited limited memory-related activity. These correlates space were more pronounced anterior posterior portions respectively. opposing gradients extended further into neocortices. Overall, our findings suggest presence orthogonal long-axis hippocampal-neocortical networks monkeys.

Language: Английский

Citations

1
Mega-scale movie-fields in the mouse visuo-hippocampal network DOI Creative Commons
Chinmay Purandare, Mayank Mehta

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Feb. 14, 2023

Natural visual experience involves a continuous series of related images while the subject is immobile. How does cortico-hippocampal circuit process episode? The hippocampus crucial for episodic memory, but most rodent single unit studies require spatial exploration or active engagement. Hence, we investigated neural responses to silent movie (Allen Brain Observatory) in head-fixed mice without any task locomotion demands, rewards. Surprisingly, third (33%, 3379/10263) hippocampal –dentate gyrus, CA3, CA1 and subiculum– neurons showed movie-selectivity, with elevated firing specific sub-segments, termed movie-fields, similar vast majority thalamo-cortical (LGN, V1, AM-PM) (97%, 6554/6785). Movie-tuning remained intact immobile spontaneously running mice. Visual had >5 movie-fields per cell, only ~2 hippocampus. movie-field durations all brain regions spanned an unprecedented 1000-fold range: from 0.02s 20s, mega-scale coding. Yet, total duration cell was comparable across regions. thus greater continuous-sequence encoding than areas, as evidenced by fewer broader areas. Consistently, repeated presentation fixed, scrambled sequence virtually abolished not visual-cortical selectivity. preference continuous, compared eight-fold further supporting episodic-sequence encoding. Movies could provide unified way probe mechanisms information processing even subjects, regions, species.

Language: Английский

Citations

3