ChAT::Cre transgenic rats show sex‐dependent altered fear behaviors, ultrasonic vocalizations and cholinergic marker expression DOI Creative Commons

Sarah C. Tryon,

Iris M. Sakamoto,

Kris F. Kaigler

et al.

Genes Brain & Behavior, Journal Year: 2023, Volume and Issue: 22(1)

Published: Jan. 13, 2023

Abstract The cholinergic system is a critical regulator of Pavlovian fear learning and extinction. As such, we have begun investigating the system's involvement in individual differences cued extinction using transgenic ChAT::Cre rat model. current study extends behavioral phenotyping line by examining both freezing behavior ultrasonic vocalizations (USVs) during paradigm. Freezing, 22 kHz USVs, 50 USVs were compared between male female ChAT::Cre+ rats their wildtype (Cre‐) littermates learning, contextual cue‐conditioned recall, extinction, generalization to novel tone. During recall froze slightly more than Cre‐ littermates, displayed significant sex freezing, USVs. Females showed males trials, but fewer distress calls recall. also produced exposure testing chambers prior tone (or shock) presentation with males, this effect was blunted females. Corroborating previous studies, overexpressed vesicular acetylcholine transporter immunolabeling basal forebrain, striatum, basolateral amygdala, hippocampus, had similar levels acetylcholinesterase numbers ChAT+ neurons as rats. This suggests that variance dependent advances theories distinct neural circuits processes regulate sexually divergent responses.

Language: Английский

Dual-binding domain electrochemiluminescence biosensing platform with self-checking function for sensitive detection of synthetic cathinone in e-cigarettes DOI

Qianying Cao,

Ding Jiang,

Lingli Zheng

et al.

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 224, P. 114963 - 114963

Published: Nov. 28, 2022

Language: Английский

Citations

17
Sex differences in fear expression and persistence in an animal model of Post-Traumatic Stress Disorder DOI Creative Commons

Eleonora Riccardi,

Giulia Federica Mancini,

Arianna Pisaneschi

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

3
ChAT::Cre transgenic rats show sex‐dependent altered fear behaviors, ultrasonic vocalizations and cholinergic marker expression DOI Creative Commons

Sarah C. Tryon,

Iris M. Sakamoto,

Kris F. Kaigler

et al.

Genes Brain & Behavior, Journal Year: 2023, Volume and Issue: 22(1)

Published: Jan. 13, 2023

Abstract The cholinergic system is a critical regulator of Pavlovian fear learning and extinction. As such, we have begun investigating the system's involvement in individual differences cued extinction using transgenic ChAT::Cre rat model. current study extends behavioral phenotyping line by examining both freezing behavior ultrasonic vocalizations (USVs) during paradigm. Freezing, 22 kHz USVs, 50 USVs were compared between male female ChAT::Cre+ rats their wildtype (Cre‐) littermates learning, contextual cue‐conditioned recall, extinction, generalization to novel tone. During recall froze slightly more than Cre‐ littermates, displayed significant sex freezing, USVs. Females showed males trials, but fewer distress calls recall. also produced exposure testing chambers prior tone (or shock) presentation with males, this effect was blunted females. Corroborating previous studies, overexpressed vesicular acetylcholine transporter immunolabeling basal forebrain, striatum, basolateral amygdala, hippocampus, had similar levels acetylcholinesterase numbers ChAT+ neurons as rats. This suggests that variance dependent advances theories distinct neural circuits processes regulate sexually divergent responses.

Language: Английский

Citations

5