ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: 16(5), P. 895 - 907

Published: Feb. 20, 2025

Ischemic stroke remains a leading cause of morbidity and mortality worldwide, early diagnosis is critical for improving clinical outcomes. This paper presents an optical design framework combining speckle contrast spectroscopy (SCOS) with multiwavelength reflectance to monitor subtle changes in cerebral blood flow during ischemic events. The research aims enable precise tissue interrogation using high-resolution, low-scatter imaging. Key the system's accuracy 1.55 μm small beam waist, grating density 1300 grooves/mm, 15.53 depth focus. calculated effective focal length 8333.33 enhances resolution 4.07 μm, detection minor properties. We investigate sensitivity various near-infrared wavelengths (660, 785, 800, 976 nm) ischemic-induced changes, particular emphasis on nm wavelength, which demonstrates superior penetration increased variations perfusion ischemia. Optical markers such as spot-size widening, spatial intensity shifts, central decrease are identified reliable indicators Our findings suggest that analysis, particularly range, provides practical, noninvasive approach continuously monitoring strokes. technique indicates potential real-time perfusion, allows continuous, management strokes, patient outcomes decision-making.

Language: Английский