Cerebral perfusion in post-stroke aphasia and its relation to residual language abilities DOI Creative Commons
Maria V. Ivanova, Ioannis Pappas,

Benjamin Inglis

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 5, 2022

ABSTRACT Stroke alters blood flow to the brain resulting in damaged tissue and cell death. Moreover, disruption of cerebral (perfusion) can be observed areas surrounding distal lesion. These structurally preserved but sub-optimally perfused regions may also affect recovery. Thus, better understand aphasia recovery relationship between perfusion language needs systematically examined. In current study, we aimed evaluate 1) how stroke affects outside lesioned chronic aphasia, 2) specific cortical perilesional relates outcomes aphasia. We analyzed data from a large sample participants with due left hemisphere ( n =43) age-matched healthy controls =25). used anatomically-defined interest that covered frontal, parietal, temporal perisylvian cortex both hemispheres, typically known support language, along several control not implicated processing. For group looked at three tissue. compared levels two groups investigated subtest scores while controlling for demographic lesion variables. First, were significantly reduced frontal parietal people group, no differences right regions. Second, found lobe (and most strongly posterior part superior middle gyri) inferior (supramarginal gyrus) was related residual expressive receptive abilities. contrast, did show such relationship; all Third, only marginally production Cumulatively, findings demonstrate is beyond site hypoperfused neural critical temporoparietal has negative impact on behavioral outcomes. results, using imaging, underscore general role play various Overall, study highlights importance exploring measures stroke.

Language: Английский

White matter tracts and executive functions: a review of causal and correlation evidence DOI
Monica Ribeiro, Yordanka Yordanova, Vincent Noblet

et al.

Brain, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 11, 2023

Executive functions are high-level cognitive processes involving abilities such as working memory/updating, set-shifting and inhibition. These complex enabled by interactions among widely distributed networks, supported white matter tracts. impairment is frequent in neurological conditions affecting matter; however, whether specific tracts crucial for normal executive unclear. We review causal correlation evidence from studies that used direct electrical stimulation during awake surgery gliomas, voxel-based tract-based lesion-symptom mapping, diffusion tensor imaging to explore associations between the integrity of healthy impaired adults. The corpus callosum was consistently associated with all processes, notably its anterior segments. Both showed prominent support superior longitudinal fasciculus functions, memory. More specifically, strong suggested second branch especially flexibility. Global results left lateralization verbal tasks right visual demands. frontal aslant tract potentially supports additional needed clarify involvement goes beyond control language. Converging indicates a right-lateralized network connecting cortical subcortical grey regions performance assessing response inhibition, some suggesting role thalamic radiation. Finally, suggests cingulum bundle discuss these findings light current knowledge about functional tracts, descriptions brain networks supporting clinical implications individuals tumours.

Language: Английский

Citations

24
Tractography Analysis of White Matter Pathways Associated with Speech Impairment in Parkinson's Disease DOI Open Access
Alpen Ortuğ, Bahar Tekin Tak, Hilal Melis Altıntaş

et al.

Dicle Medical Journal / Dicle Tip Dergisi, Journal Year: 2025, Volume and Issue: 52(1), P. 41 - 50

Published: March 13, 2025

Purpose: Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting multiple systems. Speech disorders, stemming from motor and nonmotor deficits, affect up to 89% of PD patients. This study examines the arcuate fasciculus (AF) frontal aslant tract (FAT), white matter pathways linked verbal fluency, which have not been previously assessed in PD. Methods: We included publicly available high-quality diffusion-weighted images (DWI) acquired with 120 gradient directions (b = 2500 s/mm²) 27 patients (Age: 66 ± 8, 14 M, 13 F) 26 age-, sex-, education-matched controls 64 12 F), processed using Generalized Q-sampling Imaging (GQI) model (DSI Studio software) for pathway reconstruction. The Automatic Fiber Tracking (AutoTrack) option DSI was used virtual dissection AF FAT. Diffusion metrics mean diffusivity (MD), radial (RD), axial (AD), fractional anisotropy (FA), quantitative (QA), track volume measures were obtained analyzed. Results: No significant correlation observed between fluency across control groups. However, male exhibited reduced left FAT significantly lower QA bilateral AF. Microstructural changes patients, but no found scores QA. Conclusion: Our results suggest more severe impact on microstructure compared females.

Language: Английский

Citations

0
Connectome imaging to facilitate preservation of the frontal aslant tract DOI
Harshal A. Shah,

Leonid Mittelman,

Souvik Singha

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2025, Volume and Issue: 249, P. 108726 - 108726

Published: Jan. 5, 2025

Language: Английский

Citations

0
The neuroanatomy of Broca's aphasia DOI Creative Commons

Alexis L. Pracar,

Nicoletta Biondo, Nina F. Dronkers

et al.

Frontiers in Language Sciences, Journal Year: 2025, Volume and Issue: 4

Published: Feb. 26, 2025

Introduction Broca's aphasia, a condition characterized by nonfluent speech and difficulty with language production, results from focal brain damage is most often caused stroke. Although traditionally linked to lesions in area (Brodmann areas 44 45 the left inferior frontal gyrus), recent evidence suggests that neuroanatomy of aphasia far more complex, implicating broader network cortical subcortical regions. This study aimed delineate specific white matter features that, when damaged, lead persistent aphasia. Methods 39 chronic cases 41 stroke survivors whose functions returned within normal limits (WNL) were included. Lesion analyses disconnection mapping conducted using Brainnetome Atlas Quantification Toolkit (LQT). Results highlighted critical role insula, particularly its hypergranular dorsal granular regions, which showed 99.2% 93.6% lesion overlap, respectively, cases. These along portions motor cortex parietal temporal lobes, contribute production processing. Importantly, defined minimal challenging conventional understanding In addition tract analysis revealed complete key pathways, including arcuate fasciculus, extreme capsule, middle longitudinal fasciculus. The corticospinal fronto-occipital fasciculus (IFOF) also heavily disrupted, suggesting both their structural connections contributes hallmark symptoms Discussion findings emphasize distributed nature neural underlying extending beyond traditional include multiple regions associated tracts. provides new insights into basis impairment, offering nuanced

Language: Английский

Citations

0
Alterations in microarchitecture and network integrity in diffusion tensor images of children with marginal intelligence or intellectual disabilities DOI
Zhenghua Liu, Yaming Wang, Richard Yao

et al.

Neuroradiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

Citations

0
Stroke cases with apraxia of speech due to damage to the left frontal aslant tract DOI Open Access
Masaharu Sawaki, Masahiko Yamamoto, Hiroyasu Yamamoto

et al.

Neurology and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 13(1), P. 72 - 75

Published: Aug. 9, 2024

Abstract We encountered two acute stroke cases with apraxia of speech (AOS) due to left internal border‐zone infarction. Neither case had a lower precentral gyrus lesion in the frontal lobe. The findings obtained confirmed relationship between AOS improvement and damage aslant tract (FAT) stroke. FAT integrity has potential as prognostic imaging biomarker AOS. It is important visualize fiber connections white matter using diffusion tensor tractography, which will predict outcome

Language: Английский

Citations

2
Frontal Aslant Tract and Its Role in Language: A Journey Through Tractographies and Dissections DOI
Melanie Catena Baudo, Facundo Villamil, Pablo Paolinelli

et al.

World Neurosurgery, Journal Year: 2023, Volume and Issue: 173, P. e738 - e747

Published: March 7, 2023

Language: Английский

Citations

6
The elusive metric of lesion load DOI
Mohamed L. Seghier

Brain Structure and Function, Journal Year: 2023, Volume and Issue: 228(3-4), P. 703 - 716

Published: March 22, 2023

Language: Английский

Citations

5
Frontal aslant tract in the non-dominant hemisphere: A systematic review of anatomy, functions, and surgical applications DOI Creative Commons

Clémentine Gallet,

Anne Clavreul, Florian Bernard

et al.

Frontiers in Neuroanatomy, Journal Year: 2022, Volume and Issue: 16

Published: Nov. 14, 2022

Knowledge of both the spatial organization and functions white-matter fiber tracts is steadily increasing. We report here anatomy frontal aslant tract (FAT) in non-dominant hemisphere (usually right hemisphere). Despite structural symmetry between left FAT, these two seem to display functional asymmetry, with several brain common, but others, such as visuospatial social cognition, music processing, shifting attention or working memory, more exclusively associated FAT. Further studies are required determine whether damage FAT causes permanent cognitive impairment. Such will constitute best means testing this a critical pathway that must be taken into account during neurosurgical procedures essential tasks incorporated intraoperative monitoring awake craniotomy.

Language: Английский

Citations

8
The relationship between white matter architecture and language lateralisation in the healthy brain DOI Creative Commons
Ieva Andrulyte, Christophe de Bézenac, Francesca M. Branzi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 12, 2024

Abstract Interhemispheric anatomical asymmetries have long been thought to be related language lateralisation. Previous studies explored whether in the diffusion characteristics of white matter tracts are consistent with These studies, typically smaller cohorts, yielded mixed results. This study investigated connectomic analysis quantitative anisotropy (QA) and shape features across whole brain associated We analysed 1040 healthy individuals from Human Connectome Project database. Hemispheric dominance for each participant was quantified using a laterality quotient (LQ) derived fMRI activation regions interest (ROIs) comprehension task compared against math task. A linear regression model used examine relationship between structural asymmetry functional Connectometry revealed that LQs were significantly negatively correlated QA corpus callosum tracts, including forceps minor, body, tapetum, major, indicating reduced (more bilateral representation) is increased these regions. The left arcuate fasciculus, cingulum, right cerebellar positively LQ, suggesting stronger may identify dominance. Language lateralisation not metrics (including length, span, curl, elongation, diameter, volume, surface area) all tracts. results suggest measures microstructural architecture, geometric reconstructed functions. People dependence on both cerebral hemispheres processing more developed commissural fibres, which support efficient interhemispheric communication.

Language: Английский

Citations

1