Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 14, 2024
Abstract
Nipah
virus
(NiV),
with
its
significantly
higher
mortality
rate
compared
to
COVID-19,
presents
a
looming
threat
as
potential
next
pandemic,
particularly
if
constant
mutations
of
NiV
increase
transmissibility
and
transmission.
Considering
the
importance
preventing
facilitation
entry
into
host
cells
averting
process
assembly
forming
viral
envelope,
encapsulating
nucleocapsid,
it
is
crucial
take
attachment
glycoprotein-human
ephrin-B2
matrix
protein
dual
targets.
Repurposing
approved
small
molecules
in
drug
development
strategic
choice,
leverages
known
safety
profiles,
accelerating
path
finding
effective
treatments
against
NiV.
The
from
DrugBank
were
used
for
repurposing
subjected
extra
precision
docking
followed
by
absorption,
distribution,
metabolism,
excretion,
toxicity
(ADMET)
profiling.
4
best
selected
500
ns
molecular
dynamics
(MD)
simulation
Molecular
mechanics
generalized
Born
surface
area
solvation
(MM-GBSA).
Further,
free
energy
landscape,
principal
component
analysis
defined
secondary
structure
proteins
introspected.
inclusive
proposed
that
Iotrolan
(DB09487)
Iodixanol
(DB01249)
are
inhibitors,
while
Rutin
(DB01698)
Lactitol
(DB12942)
found
actively
target
only.
Frontiers in Microbiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Jan. 25, 2022
Among
the
diseases
that
pose
a
serious
threat
to
public
health,
those
caused
by
viruses
are
of
great
importance.
The
Nipah
virus
(NiV)
belonging
Paramyxoviridae
family
was
reported
in
Malaysia
1998/1999.
Due
its
high
mortality
humans,
zoonotic
nature,
possibility
human-to-human
transmission,
and
lack
an
available
vaccine,
World
Health
Organization
(WHO)
has
recognized
it
as
global
health
problem.
Depending
on
strain
specificity,
neurological
symptoms
severe
respiratory
disorders
observed
NiV
infection.
In
most
confirmed
cases
epidemics,
appearance
humans
associated
with
presence
various
animal
species,
but
generally,
bats
Pteropus
species
considered
important
natural
reservoir
vector.
Consumption
contaminated
food,
contact
animals,
“human-to-human”
direct
were
identified
transmission
routes.
vaccines
drugs
proven
effectiveness
against
NiV,
treatment
patients
is
limited
supportive
prophylactic.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(4), P. 2060 - 2060
Published: Feb. 13, 2022
The
COVID-19
pandemic
has
evidenced
the
urgent
need
for
discovery
of
broad-spectrum
antiviral
therapies
that
could
be
deployed
in
case
future
emergence
novel
viral
threats,
as
well
to
back
up
current
therapeutic
options
drug
resistance
development.
Most
antivirals
are
directed
inhibit
specific
viruses
since
these
molecules
designed
act
on
a
target
with
objective
interfering
precise
step
replication
cycle.
Therefore,
antimicrobial
peptides
(AMPs)
have
been
identified
promising
agents
help
overcome
this
limitation
and
provide
compounds
able
more
than
single
family.
We
evaluated
activity
an
amphibian
peptide
known
its
strong
against
both
Gram-positive
Gram-negative
bacteria,
namely
Temporin
L
(TL).
Previous
studies
revealed
TL
is
endowed
widespread
possesses
marked
haemolytic
activity.
we
analyzed
previously
derivative
(Pro3,
DLeu9
TL,
where
glutamine
at
position
3
replaced
proline,
D-Leucine
enantiomer
present
9)
analogs,
their
wide
panel
comprising
enveloped,
naked,
DNA
RNA
viruses.
report
significant
inhibition
herpesviruses,
paramyxoviruses,
influenza
virus
coronaviruses,
including
SARS-CoV-2.
Moreover,
further
modified
our
best
candidate
by
lipidation
demonstrated
highly
reduced
cytotoxicity
improved
effect.
Our
results
show
potent
selective
peptides,
indicating
lipidated
temporin-based
prove
useful
additions
drugs
combatting
rising
epidemic/pandemic
emergencies.
BMJ Global Health,
Journal Year:
2024,
Volume and Issue:
9(4), P. e014386 - e014386
Published: April 1, 2024
Rapid
diagnostic
tests
(RDTs)
are
critical
for
preparedness
and
response
against
an
outbreak
or
pandemic
have
been
highlighted
in
the
100
Days
Mission,
a
global
initiative
that
aims
to
prepare
world
next
epidemic/pandemic
by
driving
development
of
diagnostics,
vaccines
therapeutics
within
days
recognition
novel
Disease
X
threat.
RDTs
play
pivotal
role
early
case
identification,
surveillance
management,
initiating
deployment
vaccine
monoclonal
antibodies.
Currently
available
RDTs,
however,
limited
clinical
sensitivity
specificity
inadequate
validation.
The
development,
validation
implementation
require
adequate
sustained
financing
from
both
public
private
sources.
While
World
Health
Assembly
recently
passed
resolution
on
capacity
strengthening
urges
individual
Member
States
commit
resources
towards
this,
is
not
binding
will
likely
be
impeded
financial
other
competing
priorities,
particularly
low-income
countries.
Meanwhile,
industry
has
sufficiently
invested
RDT
high
priority
pathogens.
Currently,
projects
getting
largest
funding
support
among
medical
countermeasures.
Yet
insufficient
tools
isolation,
incomplete
without
parallel
investment
diagnostics
therapeutics.
Pandemic
Fund,
mechanism
established
prevention,
response,
may
future
avenue
supporting
development.
In
this
paper,
we
discuss
why
response.
We
also
challenges
reflect
way
forward.
Chemical Physics Impact,
Journal Year:
2024,
Volume and Issue:
8, P. 100493 - 100493
Published: Jan. 24, 2024
Nipah
virus
(NiV),
an
emerging
highly
infectious
agent,
causes
fatal
infection
to
humans
through
zoonosis,
particularly
in
Asian
countries
including
India.
No
specific
treatment
or
vaccine
is
available
cure
combat
the
NiV
infection.
Targetable
plant-based
computer-assisted
drug
discovery
a
novel
approach
disease.
The
purpose
of
current
silico
study
was
evaluate
potential
Andrographis
paniculata
phytochemicals
act
as
molecules
disease
by
targeting
multiple
proteins:
attachment
glycoprotein
(NiV-G),
nucleoprotein
(NiV-N)
and
phosphoprotein
(NiV-P).
Six
from
A.
paniculata:
andrograpanin
(AGNN),
andrographidine
E
(AGDN),
andrographin
(AGPN),
andrographolide
(AGLD),
deoxyandrographolide
(DGLD)
neoandrographolide
(NGLD)
were
docked
against
NiV-G,
NiV-N
NiV-P.
Outcomes
molecular
docking
approved
anti-NiV
capacity
compounds
with
top
binding
affinity
NGLD
all
targets
NiV-P
energies
-8.1,
-7.7
-6.0
kcal/mol,
respectively.
dynamic
simulation
results
further
validated
protein-ligand
complexes'
stability.
Compared
phytochemicals,
standard
antivirals,
favipiravir
ribavirin,
had
low
efficacy
target
proteins.
Furthermore,
phytocompounds
displayed
acceptable
drug-likeness
ADME-Tox
(absorption,
distribution,
metabolism,
excretion,
toxicity)
profiles.
Overall,
present
findings
can
be
translated
into
preclinical
clinical
investigations
inspect
mainstream
drugs
for
Tropical Medicine & International Health,
Journal Year:
2024,
Volume and Issue:
29(5), P. 354 - 364
Published: Feb. 28, 2024
Abstract
Objectives
Nipah
and
Hendra
are
deadly
zoonotic
diseases
with
pandemic
potential.
To
date,
no
human
vaccine
or
monoclonal
antibody
(mAb)
has
been
licensed
to
prevent
disease
caused
by
these
pathogens.
The
aim
of
this
scoping
review
was
identify
describe
all
Phase
I,
II,
III
clinical
trials
candidates
mAbs
designed
in
humans
compare
the
characteristics
outlined
Target
Product
Profile
drafted
World
Health
Organisation
as
part
WHO
Research
&
Development
Blueprint
for
Action
Prevent
Epidemics.
Methods
We
searched
23
trial
registries,
Cochrane
Central
Register
Clinical
Trials,
grey
literature
up
June
2023
mAb
being
evaluated
registered
trials.
Vaccine
candidate
were
double‐extracted
evaluation
compared
preferred
critical
criteria
Organisation's
virus
vaccine.
Results
Three
(Hendra
Virus
Soluble
Glycoprotein
[HeV‐sG‐V],
PHV02,
mRNA‐1215)
one
(m102.4)
had
a
2023.
All
phase
1,
dose‐ranging
taking
place
United
States
America
Australia
enrolling
healthy
adults.
Although
meet
dose
regimen
route
administration
Profile,
other
such
measures
efficacy
reactogenicity
will
need
be
future
evidence
becomes
available.
Conclusion
Multiple
have
reached
stage
reviewed
here.
Monitoring
progress
during
entering
can
help
highlight
many
challenges
that
remain.
Microorganisms,
Journal Year:
2022,
Volume and Issue:
10(6), P. 1162 - 1162
Published: June 6, 2022
Nipah
virus
(NiV)
is
a
highly
lethal
zoonotic
paramyxovirus
that
emerged
in
Malaysia
1998.
It
human
pathogen
capable
of
causing
severe
respiratory
infection
and
encephalitis.
The
natural
reservoir
NiV,
Pteropus
fruit
bats,
remains
continuous
source
for
future
outbreaks,
although
the
bats
largely
asymptomatic.
NiV
provokes
serious
disease
various
mammalian
species.
In
recent
outbreaks
Bangladesh
India,
both
bats-to-human
human-to-human
transmissions
have
been
observed.
has
demonstrated
to
interfere
with
innate
immune
response
via
interferon
type
I
signaling,
promoting
viral
dissemination
preventing
antiviral
response.
Studies
humoral
immunity
infected
patients
animal
models
shown
NiV-specific
antibodies
were
produced
upon
protective.
on
cellular
also
found
adaptive
response,
specifically
CD4+
CD8+
T
cells,
was
stimulated
infection.
experimental
vaccines
therapeutic
strategies
developed
provided
insights
into
immunological
requirements
development
successful
medical
countermeasures
against
NiV.
This
review
summarizes
current
understanding
pathogenesis
responses
induced
Viruses,
Journal Year:
2023,
Volume and Issue:
15(3), P. 599 - 599
Published: Feb. 22, 2023
Emerging
infectious
diseases
of
zoonotic
origin
are
an
ever-increasing
public
health
risk
and
economic
burden.
The
factors
that
determine
if
when
animal
virus
is
able
to
spill
over
into
the
human
population
with
sufficient
success
achieve
ongoing
transmission
in
humans
complex
dynamic.
We
currently
unable
fully
predict
which
pathogens
may
appear
humans,
where
what
impact.
In
this
review,
we
highlight
current
knowledge
key
host–pathogen
interactions
known
influence
spillover
potential
a
particular
focus
on
two
important
viruses
origin,
Nipah
Ebola
virus.
Namely,
determining
include
cellular
tissue
tropism,
as
well
virulence
pathogenic
characteristics
pathogen
capacity
adapt
evolve
within
novel
host
environment.
also
detail
our
emerging
understanding
importance
steric
hindrance
cell
by
viral
proteins
using
“flytrap”-type
mechanism
protein
amyloidogenesis
could
be
crucial
developing
future
antiviral
therapies
against
pathogens.
Finally,
discuss
strategies
prepare
for
reduce
frequency
occurrences
order
minimize
new
outbreaks.
Health Science Reports,
Journal Year:
2023,
Volume and Issue:
6(7)
Published: July 1, 2023
The
Nipah
virus
is
a
zoonotic
infection
that
can
potentially
be
transmitted
from
person
to
as
well
through
ingesting
contaminated
food.
It
has
high
fatality
rate,
and
no
treatment
or
cure
at
present.
Several
nations
in
South
Asia
have
reported
outbreaks
occurred
during
particular
season
of
the
year.
Since
it
was
first
found
Bangladesh
2001,
there
been
total
335
people
infected
with
it,
237
those
passed
away
result
their
infection.
With
increased
public
awareness,
community
engagement,
preventative
measures,
this
fatal
suppressed.
Yet,
following
pandemic
considerable
increase
health
burden,
transmission
rate
continuously
over
few
years,
indicating
growing
possibility
become
global
concern.
Without
effective
vaccines
reliable
options,
its
capacity
for
human-to-human
potential
spread
throughout
area
could
disastrous
emergency
worldwide.
