Obesity and consequent changes in the body DOI Creative Commons
Bojana Kisić,

Dragana Puhalo-Sladoje,

D. Mirić

et al.

Praxis medica, Journal Year: 2021, Volume and Issue: 51(3), P. 35 - 43

Published: Dec. 1, 2021

<jats:p>Obesity is one of the most common chronic, non-infectious diseases in world and our country, it characterized by excessive accumulation fat tissue body an increase weight. The number obese people important global health problem. Obesity associated with cardiometabolic psychosocial comorbidities, may also affect years healthy life reduce expectancy. Numerous factors, such as biological predisposition, socioeconomic factors environmental interact influence development maintenance obesity. Excess adipose its dysfunction inflammation increased risk metabolic, mechanical mental complications. It very to monitor incidence obesity impact on chronic non-communicable expectancy due implementation strategies prevent people.</jats:p>

Language: Английский

Obesity, dyslipidemia, and cardiovascular disease: A joint expert review from the Obesity Medicine Association and the National Lipid Association 2024 DOI Creative Commons
Harold Bays, Carol F. Kirkpatrick, Kevin C. Maki

et al.

Journal of clinical lipidology, Journal Year: 2024, Volume and Issue: 18(3), P. e320 - e350

Published: April 24, 2024

BACKGROUNDThis joint expert review by the Obesity Medicine Association (OMA) and National Lipid (NLA) provides clinicians an overview of pathophysiologic clinical considerations regarding obesity, dyslipidemia, cardiovascular disease (CVD) risk.METHODSThis is based upon scientific evidence, perspectives authors, peer OMA NLA leadership.RESULTSAmong individuals with adipose tissue may store over 50% total body free cholesterol. Triglycerides represent up to 99% lipid species in tissue. The potential for expansion accounts greatest weight variance among most individuals, percent fat ranging from less than 5% 60%. While population studies suggest a modest increase blood low-density lipoprotein cholesterol (LDL-C) levels excess adiposity, adiposopathic dyslipidemia pattern often described adiposity includes elevated triglycerides, reduced high density (HDL-C), increased non-HDL-C, apolipoprotein B, LDL particle concentration, small, dense particles.CONCLUSIONSObesity increases CVD risk, at least partially due promotion adiposopathic, atherogenic profile. also worsens other cardiometabolic risk factors. Among patients interventions that reduce improve outcomes are generally associated improved levels. Given improvement LDL-C reduction overweight or early treat both (LDL-C and/or non-HDL-C) priorities reducing CVD. This risk. leadership. particles.

Language: Английский

Citations

27
Obesity, dyslipidemia, and cardiovascular disease: A joint expert review from the Obesity Medicine Association and the National Lipid Association 2024 DOI Creative Commons
Harold Bays, Carol F. Kirkpatrick, Kevin C. Maki

et al.

Obesity Pillars, Journal Year: 2024, Volume and Issue: 10, P. 100108 - 100108

Published: March 12, 2024

This joint expert review by the Obesity Medicine Association (OMA) and National Lipid (NLA) provides clinicians an overview of pathophysiologic clinical considerations regarding obesity, dyslipidemia, cardiovascular disease (CVD) risk. is based upon scientific evidence, perspectives authors, peer OMA NLA leadership. Among individuals with adipose tissue may store over 50% total body free cholesterol. Triglycerides represent up to 99% lipid species in tissue. The potential for expansion accounts greatest weight variance among most individuals, percent fat ranging from less than 5% 60%. While population studies suggest a modest increase blood low-density lipoprotein cholesterol (LDL-C) levels excess adiposity, adiposopathic dyslipidemia pattern often described adiposity includes elevated triglycerides, reduced high density (HDL-C), increased non-HDL-C, apolipoprotein B, LDL particle concentration, small, dense particles. increases CVD risk, at least partially due promotion adiposopathic, atherogenic profile. also worsens other cardiometabolic risk factors. patients interventions that reduce improve outcomes are generally associated improved levels. Given improvement LDL-C reduction overweight or early treat both (LDL-C and/or non-HDL-C) priorities reducing CVD.

Language: Английский

Citations

19
Obesity, thrombosis, venous disease, lymphatic disease, and lipedema: An obesity medicine association (OMA) clinical practice statement (CPS) 2023 DOI Creative Commons

Shagun Bindlish,

Jennifer Ng,

Wissam Ghusn

et al.

Obesity Pillars, Journal Year: 2023, Volume and Issue: 8, P. 100092 - 100092

Published: Oct. 19, 2023

This Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) is intended to provide clinicians with an overview on obesity, thrombosis, venous disease, lymphatic and lipedema.

Language: Английский

Citations

13
An unbiased, sustainable, evidence-informed Universal Food Guide: a timely template for national food guides DOI Creative Commons
Elizabeth Dean,

Xu Jia,

Alice Jones

et al.

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 18, 2024

Language: Английский

Citations

5
Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis DOI Creative Commons
Harold Bays,

LeAnne T. Bloedon,

Danielle M. Brennan

et al.

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Background Obesity and hypercholesterolemia independently increase cardiovascular disease risk. This analysis evaluated the efficacy safety of bempedoic acid in people with obesity participating CLEAR (Cholesterol Lowering via Bempedoic Acid [ECT1002], an ACL‐Inhibiting Regimen) Outcomes trial. Methods randomized 13 970 patients to daily 180 mg or placebo. Exploratory outcomes including major adverse events‐4 (cardiovascular death, nonfatal myocardial infarction, stroke, coronary revascularization), low‐density lipoprotein cholesterol, hs‐CRP (high‐sensitivity C‐reactive protein), weight change, were assessed over a median 40.7 months 6177 baseline body mass index ≥30 kg/m 2 . Results In obesity, resulted placebo‐corrected reductions cholesterol −22.5% −23.2% at 6 months. treatment reduction 23% (hazard ratio [HR], 0.77 [95% CI, 0.67–0.89]) versus Nonfatal fatal MI reduced by 32% (HR, 0.68 0.53–0.86]), revascularization was 24% 0.76 0.63–0.92]), stroke 36% 0.64 0.45–0.89]) compared At month 36, mean±SD change from −2.3 (6.3) kg for −1.4 (6.1) Adverse events reported 87.4% 86.7% placebo patients. The uric 0.81 (1.26) mg/dL −0.04 (1.05) Conclusions Among events, hs‐CRP, profile consistent previous reports. Registration URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT02993406.

Language: Английский

Citations

0
Obesity Management in Primary Care: A Joint Clinical Perspective and Expert Review from the Obesity Medicine Association (OMA) and the American College of Osteopathic Family Physicians (ACOFP) - 2025 DOI Creative Commons
N. J. Pennings, Catherine Varney,

Stephanie L. Hines

et al.

Obesity Pillars, Journal Year: 2025, Volume and Issue: unknown, P. 100172 - 100172

Published: March 1, 2025

This collaboration from the Obesity Medicine Association (OMA) and American College of Osteopathic Family Physicians (ACOFP) examines obesity management a primary care perspective. joint perspective is based upon scientific evidence, clinical experience authors, peer review by OMA ACOFP leadership. The goal to identify answer sentinel questions about perspective, utilizing evidence-based publications, guided expert experience. disease that contributes both biomechanical complications most common cardiometabolic abnormalities encountered in care. Barriers impede optimal patients with include failure recognize as disease, lack accurate diagnosis, insufficient access treatment resources, inadequate training, time, adequate reimbursement adverse impact bias, stigma, discrimination. physicians are often first line healthcare setting. affords early intervention opportunities prevent and/or treat overweight obesity. Patient enhanced when clinicians risks benefits anti-obesity medications bariatric procedures, well long-term follow-up. Practical tools regarding 4 pillars nutrition therapy, physical activity, behavior modification, medical interventions (anti-obesity surgery) may assist improve health lives living

Language: Английский

Citations

0
Long-term Endurance Training as a Modulator for Preventing Cardiovascular Disease Risk in Obese Individuals DOI Creative Commons
Adi Pranoto, Shidqi Hamdi Pratama Putera, Dewangga Yudhistira

et al.

Physical Education Theory and Methodology, Journal Year: 2025, Volume and Issue: 25(2), P. 221 - 227

Published: March 30, 2025

Objectives. This study aimed to evaluate the long-term effects of endurance training as a modulator in prevention cardiovascular disease risk obese individuals. Materials and methods. used true experimental method with pretest-posttest control group design. Twenty-five women aged 20-30 years body fat percentage ≥30% were assigned (CNT) an exercise (EXC). The EXC underwent eight-week (three sessions per week) program (treadmill) lasting 40-60 minutes session. Blood pressure (BP), mean arterial (MAP), resting heart rate (RHR) measured using OMRON HBP-9030 digital tensiometer Polar H10 sensor at start (pre) after eight weeks (post) training. Results. Significant reductions systolic blood (SBP), diastolic (DBP), MAP, RHR detected between pre- post-endurance phases (all p ≤ 0.001). Additionally, notable decrease SBP, DBP, was observed groups 0.05). Conclusions. findings indicate effectiveness intervention, contributing consistent reduction women.

Language: Английский

Citations

0
Carotid baroreceptor stimulation attenuates obesity-related hypertension through sympathetic-driven IL- 22 restoration of intestinal homeostasis DOI Creative Commons
Ling Shu,

Lingling Xiao,

Bangwang Hu

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 15, 2025

Gut microbiota and its metabolites, as well the intestinal barrier, play important roles in development of obesity-related hypertension. Sympathetic nerves are critical for homeostasis. Carotid baroreceptor stimulation (CBS) has been shown to exert protective effects against hypertension via sympathetic tone reduction. This study aimed reveal CBS treatment on homeostasis underlying mechanisms An animal model was established with Sprague-Dawley rats by a high-fat diet 10% fructose solution 13 weeks. devices were implanted at 5 th week. The body weight, blood pressure, gut microbiota, autonomic nerve, type 3 innate lymphoid cells (ILC3 s) investigated. significantly reduced pressure weight In addition, obviously improved microbial dysbiosis barrier damage. Interestingly, after an 8-week intervention, hypertensive exhibited dramatic decrease nerve distribution norepinephrine concentration, increase IL- 22 production ILC3 s intestine. increased alleviate destruction, thus improving rats.

Language: Английский

Citations

0
Effects of phentermine / topiramate extended-release, phentermine, and placebo on ambulatory blood pressure monitoring in adults with overweight or obesity: A randomized, multicenter, double-blind study DOI Creative Commons
Harold Bays, Daniel S. Hsia, Lan Thi Nguyen

et al.

Obesity Pillars, Journal Year: 2024, Volume and Issue: 9, P. 100099 - 100099

Published: Jan. 8, 2024

A fixed-dose combination of phentermine and extended-release topiramate (PHEN/TPM - approved for weight management) has demonstrated in-clinic reduction blood pressure (BP). Ambulatory BP monitoring (ABPM) may be a better predictor cardiovascular disease risk than BP.

Language: Английский

Citations

2
Dietary determinants of overnutrition among hypertensive patients in southwest Ethiopia: an ordinal regression model DOI Creative Commons

Mulate Gebre,

Girma Alemayehu Beyene,

Ebrahim Muktar

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 2, 2024

Abstract Overnutrition is a recognized risk factor for hypertension, but evidence lacking among hypertensive patients tailored dietary interventions. This study assessed factors in 331 southwest Ethiopia. The data was collected through questionnaire and analyzed using analysis. Body mass index (BMI) calculated, BMI above 25 kg m −2 considered overnutrition. An ordinal logistic regression model used to the control confounders. Adjusted odds ratio p -values were reported. Among respondents, consumption of cereals grains (57.0%); roots tubers (58.5); legumes (50.0%), while 28.6% drink alcohol, common. About 29.0% (24.1–34.2) had overnutrition (22%, 17.6–26.6%, overweight 7.0%, 4.5–10.3%, obesity). While predicted higher males (AOR = 2.85; 1.35–6.02), married 1.47; 0.69–3.12), illiterates 2.09; 1.18–3.72), advanced age 1.65; 0.61–4.61), government employees 6.83; 1.19–39.2), urban dwellers 4.06; 1.76–9.36), infrequent vegetable 0.72–2.96) lower terciles animal-source food 1.56; 0.72–3.34). significantly high associated with unhealthy consumption, educational status, residence, occupation, emphasizing need targeted counseling.

Language: Английский

Citations

2