Infection and Drug Resistance,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 5729 - 5740
Published: Aug. 1, 2023
Background:
Virus
infection
can
cause
the
changes
of
lncRNA
expression
levels
to
regulate
interaction
between
virus
and
host,
but
relationship
BHV-1
has
not
been
reported.
Methods:
In
this
study,
in
order
reveal
molecular
mechanism
RNA
BoHV-1
infection,
Madin-Darby
bovine
kidney
(MDBK)
cells
were
infected
with
BoHV-1,
transcriptome
sequencing
performed
by
next-generation
at
18
h
or
24
33
viral
then
based
on
competitive
endogenous
(ceRNA)
theory,
lncRNA-miRNA-mRNA
networks
constructed
using
these
high-throughput
data.
The
network
analysis,
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
analysis
for
functional
annotation
exploration
ncRNA
ceRNAs
infection.
Results:
results
showed
that
48
lncRNAs,
123
mRNAs
20
miRNAs
as
differentially
expressed
genes,
mitogen
activated
protein
kinase
(MAPK)
calcium
signaling
significantly
enriched
ceRNA
network.
Some
genes
randomly
selected
verification
RT-qPCR,
their
trend
was
consistent
Conclusion:
This
study
revealed
affect
RNAs
MDBK
regulation
carry
out
corresponding
biological
functions
further
experimental
studies
are
still
necessary
prove
hub
function
Keywords:
bioinformatics
network,
Journal of Translational Internal Medicine,
Journal Year:
2023,
Volume and Issue:
11(4), P. 372 - 381
Published: Dec. 1, 2023
Circular
RNAs
(circRNAs)
are
a
class
of
single-stranded
with
covalently
closed
structures.
Owing
to
their
not
having
3'
or
5'
ends,
circRNAs
highly
durable
and
insusceptible
exonuclease-mediated
degradation.
Moreover,
some
certain
structures
translatable,
making
them
novel
vaccines.
Vaccines
efficient
tools
for
immunotherapy,
such
as
the
prevention
infectious
diseases
cancer
treatment.
The
immune
system
is
activated
during
immunotherapy
fight
against
abnormal
allies
invaders.
CircRNA
vaccines
represent
potential
new
avenue
in
vaccine
era.
Recently,
several
circRNA
have
been
synthesized
tested
vitro
vivo.
Our
review
briefly
introduces
current
understanding
biology
function
translatable
circRNAs,
molecular
biology,
synthetic
methods,
delivery
circRNA,
We
also
discussed
challenges
future
directions
field
by
summarizing
developments
past
few
years.
Non-Coding RNA,
Journal Year:
2023,
Volume and Issue:
9(4), P. 38 - 38
Published: July 4, 2023
Circular
RNAs
(circRNAs)
represent
single-stranded
RNA
species
that
contain
covalently
closed
3′
and
5′
ends
provide
them
more
stability
than
linear
RNA,
which
has
free
ends.
Emerging
evidence
indicates
circRNAs
perform
essential
functions
in
many
DNA
viruses,
including
coronaviruses,
Epstein–Barr
cytomegalovirus,
Kaposi
sarcoma
viruses.
Recent
studies
have
confirmed
are
present
play
various
important
such
as
evading
host
immune
response,
disease
pathogenesis,
protein
translation,
miRNA
sponges,
regulating
cell
proliferation,
virus
replication.
Studies
can
be
biological
signatures
or
pathological
markers
for
autoimmune
diseases,
neurological
cancers.
However,
our
understanding
of
viruses
is
still
limited,
functional
evaluation
viral
to
completely
understand
their
functions.
In
the
review,
we
describe
metabolism
cellular
roles
circRNA,
its
diseases
circRNA
found
interact
with
proteins,
DNA,
thus
modulate
processes,
transcription,
splicing,
other
interfere
signaling
pathways
take
part
vital
biological,
physiological,
cellular,
pathophysiological
processes.
We
also
summarize
recent
demonstrating
circRNA’s
this
growing
field
research.
Cancer Letters,
Journal Year:
2023,
Volume and Issue:
564, P. 216219 - 216219
Published: May 3, 2023
Tumor
immunotherapy
is
a
new
therapeutic
approach
that
has
been
evolving
in
the
last
decade
and
dramatically
changed
treatment
options
for
cancer.
Circular
RNAs
(circRNAs)
are
non-coding
(ncRNAs)
with
high
stability,
tissue-specific
cell-specific
expression.
There
growing
evidence
circRNAs
involved
regulation
of
both
adaptive
innate
immunity.
They
play
important
roles
tumor
by
affecting
macrophage,
NK
T
cell
function.
The
stability
tissue
specificity
make
them
ideal
candidate
biomarkers
effects.
CircRNAs
also
represent
one
promising
targets
or
adjuvant
immunotherapy.
Investigations
this
field
progress
rapidly
provide
essential
support
diagnosis,
prognosis
guidance
cancers
future.
In
review,
we
summarize
role
on
immunity
from
viewpoint
immunity,
explore
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
162, P. 114615 - 114615
Published: April 1, 2023
Cell
therapy
is
one
of
the
methods
that
have
shown
promising
results
in
treating
diseases
recent
decades.
However,
use
different
types
cells
comes
with
limitations.
The
application
immune
cell
can
lead
to
cytokine
storms
and
inappropriate
responses
self-antigens.
Also,
stem
has
potential
create
tumors.
may
not
migrate
injury
site
after
intravenous
injection.
Therefore,
using
exosomes
from
as
therapeutic
candidates
were
proposed.
Due
their
small
size
favorable
characteristics,
such
biocompatibility
immunocompatibility,
easy
storage
isolation,
attracted
much
attention.
They
are
used
many
diseases,
including
cardiovascular
orthopedic
autoimmune
cancer.
various
studies
efficiency
(Exo)
be
increased
by
loading
drugs
microRNAs
inside
them
(encapsulated
exosomes).
analyzing
investigating
encapsulated
exosomes'
ability
critical.
In
this
study,
we
examined
related
cancer
infectious
regenerative
medicine.
Compared
intact
exosomes,
show
a
higher
ability.
Therefore
it
suggested
method
depending
on
treatment
type
increase
treatment's
efficiency.
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(8)
Published: Aug. 25, 2023
Breast
cancer
(BC)
is
one
of
the
most
frequent
cancer-related
deaths
in
women
worldwide.
Studies
have
shown
potential
impact
circRNAs
multiple
human
tumorigeneses.
Research
on
vital
signaling
pathways
and
therapeutic
targets
indispensable.
Here,
we
aimed
to
investigate
clinical
implications
underlying
mechanisms
circ_0042881
BC.
RT-qPCR
validated
was
notably
elevated
BC
tissues
plasma,
closely
associated
with
clinicopathological
features.
Functionally,
significantly
accelerated
proliferation,
migration,
invasion
cells
vitro
tumor
growth
metastasis
vivo.
Mechanistically,
promoted
progression
by
sponging
miR-217
relieve
its
inhibition
effect
son
sevenless
1
(SOS1),
which
further
activated
RAS
protein
initiated
downstream
cascades,
including
MEK/ERK
pathway
PI3K/AKT
pathway.
We
also
demonstrated
that
treatment
BAY-293,
an
inhibitor
SOS1
interaction,
attenuated
induced
overexpression.
Furthermore,
Eukaryotic
initiation
factor
4A-III
(EIF4A3)
could
facilitate
circularization.
Altogether,
proposed
a
novel
network
circ_0042881,
EIF4A3,
influences
process
tumorigenesis
miR-217/SOS1
axis.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6387 - 6387
Published: June 9, 2024
Endometrial
cancer
(EC)
is
one
of
the
most
common
malignant
tumors
among
women
in
21st
century,
whose
mortality
rate
increasing
every
year.
Currently,
diagnosis
EC
possible
only
after
a
biopsy.
However,
it
necessary
to
find
new
biomarker
that
will
help
both
and
treatment
non-invasive
way.
Circular
RNAs
(circRNAs)
are
small,
covalently
closed
spherical
stable
long
non-coding
(lncRNAs)
molecules,
which
abundant
body
fluids
human
tissues
expressed
various
ways.
Considering
molecular
classification
EC,
many
studies
have
appeared,
describing
insights
into
functions
mechanisms
circRNAs
EC.
In
this
review
article,
we
focused
on
problem
aspects
its
division,
as
well
biogenesis,
functions,
diagnostic
clinical
significance
Exploration of Medicine,
Journal Year:
2025,
Volume and Issue:
6
Published: April 28, 2025
The
interaction
between
cancer
and
coronavirus
disease
2019
(COVID-19)
poses
significant
challenges,
particularly
for
immunocompromised
individuals
who
are
at
heightened
risk
acute
infections
long-term
complications.
pandemic
has
exacerbated
existing
vulnerabilities
in
care
by
disrupting
treatment
protocols
delaying
diagnoses,
leading
to
worsened
health
outcomes.
This
article
emphasizes
the
importance
of
investigating
potential
impact
severe
respiratory
syndrome
2
(SARS-CoV-2)
on
progression
highlights
need
effective
strategies
protect
this
high-risk
population.
Long-term
consequences,
including
emergence
long
COVID,
further
emphasize
ongoing
surveillance
comprehensive
healthcare
planning
patients
during
after
pandemics.
A
multifaceted
approach
is
essential,
incorporating
vaccination,
timely
therapeutic
interventions,
sustained
support
with
lingering
symptoms.
also
discusses
urges
continued
research
into
oncogenic
risks
associated
SARS-CoV-2,
which
crucial
enhancing
our
understanding
broader
implications
COVID-19
informing
public
aimed
safeguarding
future
Moreover,
data
collection
development
refined
clinical
guidelines
vital
improving
patient
outcomes
preparing
systems
crises.
Additionally,
mechanisms
SARS-CoV-2
may
increase
susceptibility,
chronic
inflammation,
cellular
senescence,
immune
dysregulation.
Understanding
these
elucidating
virus’s
potential,
among
survivors
infections.
Ensuring
continuity
resilience
global
crises
requires
mitigate
disruptions,
enhance
access
screenings
treatments,
address
specific
challenges
faced
experiencing
COVID.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: July 15, 2024
Circular
RNAs
(circRNAs)
constitute
a
class
of
endogenous
non-coding
(ncRNAs)
that
lack
5'-ended
cap
and
3'-ended
poly
(A)
tail
form
closed
ring
structure
with
covalent
bonds.
Due
to
its
special
structure,
circRNA
is
resistant
Exonuclease
R
(RNaseR),
making
distribution
in
the
cytoplasm
quite
rich.
Advanced
high-throughput
sequencing
bioinformatics
methods
have
revealed
highly
conserved,
stable,
disease-
tissue-specific.
Furthermore,
increasing
research
has
confirmed
circRNA,
as
driver
or
suppressor,
regulates
cancer
onset
progression
by
modulating
series
pathophysiological
mechanisms.
As
result,
emerged
clinical
biomarker
therapeutic
intervention
target.
This
article
reviews
biological
functions
regulatory
mechanisms
context
respiratory
progression.