Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
Life Sciences,
Journal Year:
2024,
Volume and Issue:
352, P. 122899 - 122899
Published: July 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Clinical and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 19, 2024
Abstract
Humanity
is
suffering
from
cancer
which
has
become
a
root
cause
of
untimely
deaths
individuals
around
the
globe
in
recent
past.
Nanotheranostics
integrates
therapeutics
and
diagnostics
to
monitor
treatment
response
enhance
drug
efficacy
safety.
We
hereby
propose
discuss
all
imaging
diagnostic
tools,
mechanism
targeting
tumor
cells,
current
nanotheranostic
platforms
available
for
cancer.
This
review
discusses
various
agents
novel
molecular
tools
like
MRI,
CT,
PET,
SPEC,
PAT
used
diagnostics.
Emphasis
given
gold
nanoparticles,
silica,
liposomes,
dendrimers,
metal-based
agents.
also
highlight
limitations
different
field
research
treatment.
Due
complexity
this
area,
multifunctional
hybrid
nanoparticles
functionalized
with
targeted
moieties
or
anti-cancer
drugs
show
best
feature
theranostics
that
enables
them
work
on
carrying
delivering
active
materials
desired
area
requirement
early
detection
diagnosis.
Non-invasive
techniques
have
specificity
receptor
binding
internalization
processes
nanosystems
within
cells.
may
provide
appropriate
medicine
at
dose
patient
time.
Graphical
abstract
Journal of Nanotheranostics,
Journal Year:
2023,
Volume and Issue:
4(3), P. 248 - 279
Published: July 1, 2023
Zinc
oxide
nanomaterials
have
been
the
cynosure
of
this
decade
because
their
immense
potential
in
different
biomedical
applications.
It
includes
usage
prognosis
and
treatment
infectious
cellular
diseases,
owing
to
peculiar
physiochemical
properties
such
as
variable
shape,
size,
surface
charge
etc.
Increasing
demand
ZnO
raise
concerns
about
molecular
toxicity
biocompatibility
with
human
cells.
This
review
comprehensively
details
for
Furthermore,
toxicological
types
systems
reviewed.
Moreover,
biocompatible
efficacy
cancer
specific
pathways
has
discussed.
offers
insights
into
current
scenario
signifies
future
extension
on
environmental
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(31), P. 33303 - 33334
Published: July 25, 2024
The
increasing
occurrence
of
infectious
diseases
caused
by
antimicrobial
resistance
organisms
urged
the
necessity
to
develop
more
potent,
selective,
and
safe
agents.
unique
magnetic
tunable
properties
iron
oxide
nanoparticles
(IONPs)
make
them
a
promising
candidate
for
different
theragnostic
applications,
including
Though
IONPs
act
as
nonspecific
agent,
their
activities
are
directly
or
indirectly
linked
with
synthesis
methods,
synthesizing
precursors,
size,
shapes,
concentration,
surface
modifications.
Alteration
these
parameters
could
accelerate
decelerate
production
reactive
oxygen
species
(ROS).
An
increase
in
ROS
role
disrupts
bacterial
cell
walls,
membranes,
alters
major
biomolecules
(e.g.,
lipids,
proteins,
nucleic
acids),
affects
metabolic
processes
Krebs
cycle,
fatty
acid
synthesis,
ATP
glycolysis,
mitophagy).
In
this
review,
we
will
investigate
antibacterial
activity
bare
surface-modified
influence
physiochemical
on
activity.
Additionally,
report
potential
mechanism
IONPs'
action
driving
Nano Select,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
ABSTRACT
The
applications
of
nanoparticles
(NPs)
have
shown
tremendous
growth
during
the
last
decade
in
field
biomedicine.
Although
chemical
and
physical
methods
dominate
large‐scale
NP
synthesis,
such
are
also
known
for
their
adverse
impact
on
environment
health.
In
contrast,
use
biological
systems
provides
a
sustainable
alternative
producing
functional
NPs
by
biomineralization
process.
transformative
power
artificial
intelligence
(AI)
has
been
proven
prudent
diagnosis,
drug
development,
therapy,
clinical
decision‐making.
AI
can
be
utilized
tailored
design,
scale‐up
biomedical
applications.
present
review
an
overview
process
its
advantages
over
other
eco‐friendly
synthesis
opportunities.
Specific
emphasis
is
provided
application
cancer
therapy
how
biologically
compatible
improve
management.
Finally,
to
best
our
knowledge,
potential
integrating
comprehensively
analyzed
first
time.
Additionally,
help
surpass
conventionally
synthesized
toxicity
toxicology
material
science
provided.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(29), P. 14033 - 14056
Published: Jan. 1, 2024
Theranostic
nanogels
are
indispensable
modular
platforms
that
enable
a
combined
approach
to
therapy
and
diagnostics
address
challenges
in
the
treatment
of
complex
dynamic
diseases
such
as
cancer.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 177 - 177
Published: Jan. 26, 2024
Curcumin
is
a
natural
compound
that
has
been
widely
investigated
thanks
to
its
various
biological
properties,
including
antiproliferative.
This
molecule
acts
on
different
cancers
such
as
lung,
breast,
pancreatic,
colorectal,
etc.
However,
the
bioactive
actions
of
curcumin
have
limitations
when
physicochemical
properties
compromise
pharmacological
potential.
As
therapeutic
strategy
against
cancer,
associated
with
inorganic
nanoparticles.
These
nanocarriers
are
capable
delivering
and
offering
synergistically
enhance
anticancer
properties.
review
highlights
types
curcumin-based
nanoparticles
discusses
their
in
vivo
activity
models
cancer.
