Published: Nov. 15, 2024
Language: Английский
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Dec. 1, 2023
Vascular endothelial cells play a vital role in the health and maintenance of vascular homeostasis, but hyperglycemia disrupts their function by increasing cellular oxidative stress. Resveratrol, plant polyphenol, possesses antioxidant properties that can mitigate Addressing challenges its limited solubility stability, gold nanoparticles (GNps) were utilized as carriers. A microfluidic chip (MFC) with dynamic flow conditions was designed to simulate body vessels investigate resveratrol (RGNps), citrate (CGNps), free Resveratrol on human umbilical vein (HUVEC). The 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay employed measure extracellular potential, cell viability determined using Alamar Blue test. For assessing intracellular stress, 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) conducted, results from both culture plate MFC compared. Free demonstrated peak DPPH scavenging activity had about 24-35%. RGNPs, 3.0 ± 0.5 nm 20.2 4.7 nm, consistently showed high (more than 90%) across tested concentrations. Notably, RGNPs (20 nm) exhibited antioxidative through (%) range approximately 38-86% which greater CGNps at 21-32%. In MFC,the DCFH-DA analysis indicated reduced stress 57-82%, surpassing Resveratrol. Morphologically, presented superior structure compared those traditional plates, induction successfully led formation multinucleated variant (MVECs). provides distinct advantage observing morphology inducing dysfunction. RGNps have significant potential alleviating preventing disorders.
Language: Английский
Citations
9
Journal of Pharmaceutical Investigation, Journal Year: 2023, Volume and Issue: 53(5), P. 571 - 599
Published: June 30, 2023
Language: Английский
Citations
5
International Communications in Heat and Mass Transfer, Journal Year: 2024, Volume and Issue: 156, P. 107590 - 107590
Published: May 21, 2024
Language: Английский
Citations
1
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102394 - 102394
Published: June 29, 2024
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1264 - 1264
Published: Sept. 27, 2024
Microparticle-based drug delivery systems offer several advantages for protein-based formulations, enhancing patient compliance and therapeutic efficiency through the sustained of active pharmaceutical ingredient. Over past few decades, microfluidics method has emerged as a continuous manufacturing process preparing drug-encapsulating microparticles, mainly small molecule drugs. However, comparative assessments conventional batch vs. formulations have been lacking. The main objective this study was to generate immunomodulatory protein drug-loaded injectable using both methods.
Language: Английский
Citations
1
Physics of Fluids, Journal Year: 2023, Volume and Issue: 35(7)
Published: July 1, 2023
Droplet micro-mixing is a critical aspect limiting the accuracy of chemical analysis and quality drug screening, requiring efficient mixing target concentrations in limited volume. In this paper, ternary dilute solute lattice Boltzmann model used to study processes mechanisms solutes inside Janus droplets. The influence three factors including droplet velocity, tilt angle volume ratio on efficiency examined. results show that there main circulation “dead zone” droplet. With increasing both intensity occupied increase, which make increase. At different angles, difference strength internal flow field makes “windward part” greater than “leeward part.” When keeping r-phase constant g-phase, diffusion distance shortened reduced. competes with reinforcing effect field, finally shows tendency larger r: g, faster mix complete. will provide theoretical support for further improvement micro-mixer efficiency.
Language: Английский
Citations
1
Journal of Diabetes & Metabolic Disorders, Journal Year: 2024, Volume and Issue: 23(1), P. 323 - 331
Published: Jan. 18, 2024
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 257 - 267
Published: Jan. 1, 2024
Language: Английский
Citations
0
Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 310 - 341
Published: Aug. 14, 2024
There are indications that more than 90% of drug development endeavours for clinical uses were unsuccessful despite employing various experimentally proven strategies. This observation necessitates looking closely at whether some key optimisation processes disregarded during preclinical trials. The factors need to be strictly considered delivery systems include rapid and high-throughput screening technologies with accurate quicker dispensing small liquid volumes considering the biological design certain tissues their specific biomechanical properties mimic conditions presented in vivo. Microfluidics have garnered much attention provide a quicker, reproducible, affordable substitute deliver drugs targeted controlled manner. purpose this chapter is most recent developments construction vitro microfluidic designs could utilized cell tissue administration. In subsequent section, we comprehensively discussed benefits obstacles they still overcome become cornerstone pharmaceutical research.
Language: Английский
Citations
0
Published: Nov. 15, 2024
Language: Английский
Citations
0