Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Rett Syndrome, a neurodevelopmental disorder caused by loss-of-function mutations in the MECP2 gene, is characterized severe motor, cognitive and emotional impairments. Some of deficits may result from changes cortical connections, especially downstream projections prefrontal cortex, which also be targets restoration following rearing conditions such as environmental enrichment that alleviate specific symptoms. Here, using heterozygous Mecp2 +/- female mouse model closely analogous to human we investigated impact early on behavioral cortex connectivity. Behavioral analyses revealed enriched housing rescued fine motor reduced anxiety, with enrichment-housed mice performing comparably wild-type (WT) controls rotarod open field assays. Anatomical mapping top-down anterior cingulate (ACA) demonstrated altered connectivity mice, increased axonal density somatosensory decreased compared WT controls. ACA axons shifts hemispheric distribution, particularly medial network regions, exhibiting ipsilateral dominance. These were unaffected housing, suggesting structural abnormalities persist despite improvements. Enriched brain-derived neurotrophic factor (BDNF) levels hippocampus but failed restore BDNF consistent persistent observed projections. findings highlight focal nature induced reduction MeCP2 exposure enrichment, suggest starting adolescence can without reversing large-scale

Language: Английский

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Environmental enrichment for neuropathic pain via modulation of neuroinflammation

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: March 21, 2025

Neuropathic pain causes tremendous biological and psychological suffering to patients worldwide. Environmental enrichment (EE) is a promising non-pharmacological strategy with high cost-effectiveness reduce neuropathic support rehabilitation therapy. Three researchers reviewed previous studies determine the efficacy of EE for research how improves through neuroinflammation. For this review, Embase, PubMed, Cochran were searched. authors did study selection data extraction. Out 74 papers, 7 met inclusion criteria. In chronic constriction injury rats acute or detrimental stimulation, change behavior was influenced by environmental settings like start time, cage size. Besides, physical has larger effect than socially in inflammatory pain. These articles suggest employing various regulate release pain-causing substances changes ion channels peripheral central nerves improve depression anxiety conditions. The existing proof provides important knowledge upcoming preclinical investigations practical use clinical treatment. This analysis aids advancement improved approaches managing pain, focus on internal mechanisms controlling

Language: Английский

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Pro-resilient effects of environmental enrichment on social isolation: behavioural and cytochrome c oxidase brain analysis in Wistar adult rats

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115574 - 115574

Published: April 1, 2025

Language: Английский

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Environmental Enrichment Enhances Cerebellar Compensation and Develops Cerebellar Reserve

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(9), P. 5697 - 5697

Published: May 7, 2022

The brain is able to change its structure and function in response environmental stimulations. Several human animal studies have documented that enhanced stimulations provide individuals with strengthened allow them better cope damage. In this framework, based on the exposure of animals enrichment (EE) provided indications mechanisms involved such a beneficial action. cerebellum very plastic region responds every experience deep structural functional rearrangement. present review specifically aims collect synthesize evidence by models EE effects cerebellar considering healthy subjects exposed both before after damage involving functionality. On whole, supports role enhancing compensation developing reserve. However, since addressing issue are still scarce, large areas inconsistency lack clarity remain. Further required suggestions possible enhancement compensatory responses patients following

Language: Английский

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Home-cage behavior is impacted by stress exposure in rats

Frontiers in Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: June 9, 2023

Being social animals, rats exhibit a range of behaviors that help them build bonds and maintain group cohesion. Behavior is influenced by multiple factors, including stress exposure, the expression impact on both non-social may also be affected living conditions rats. In this study, we explored physiological behavioral effects chronic unpredictable group-housed in PhenoWorld (PhW), socially physically enriched environment closer to real-life conditions. Two independent experiments were performed: one control condition (PhW control, n = 8) stress, 8). Control animals remained undisturbed except for cage cleaning daily handling procedures. Stress all exposed stress. Data confirm exposure triggers anxiety-like behavior PhW. terms home-cage behaviors, found affects (by decreased playing increased huddling behaviors) (as shown decrease rearing walking behaviors). These results are relevance expand our knowledge influence which importance understand better species-typical behaviors.

Language: Английский

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Experience-dependent information routing through the basolateral amygdala shapes behavioral outcomes

Cell Reports, Journal Year: 2024, Volume and Issue: 43(7), P. 114489 - 114489

Published: July 1, 2024

It is well established that the basolateral amygdala (BLA) an emotional processing hub governs a diverse repertoire of behaviors. Selective engagement heterogeneous cell population in BLA thought to contribute this flexibility behavioral outcomes. However, whether process impacted by previous experiences influence remains unclear. Here we demonstrate positive (enriched environment [EE]) or negative (chronic unpredictable stress [CUS]) differentially activity populations principal neurons projecting either nucleus accumbens core bed stria terminalis. Chemogenetic manipulation these projection-specific can mimic occlude effects CUS and EE on outcomes bidirectionally control avoidance behaviors stress-induced helplessness. These data responsiveness neurons, biasing information routing through BLA, drive divergent

Language: Английский

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Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders

Experimental & Molecular Medicine, Journal Year: 2021, Volume and Issue: 53(3), P. 358 - 368

Published: March 1, 2021

Psychiatric illness is a prevalent and highly debilitating disorder, more than 50% of the general population in both middle- high-income countries experience at least one psychiatric disorder some point their lives. As we continue to learn how pervasive episodes are society, must acknowledge that disorders not solely relegated small group predisposed individuals but rather occur significant portions all societal groups. Several distinct brain regions have been implicated neuropsychiatric disease. These include corticolimbic structures, which regulate executive function decision making (e.g., prefrontal cortex), as well striatal subregions known control motivated behavior under normal stressful conditions. Importantly, neural circuitry includes hippocampus, critical structure sends projections cortex striatum coordinate learning, memory, mood. In this review, will discuss past recent discoveries neurobiological processes hippocampus structures work concert function, mood context mental disorders.

Language: Английский

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Environmental enrichment modulates HPA axis reprogramming in adult male rats exposed to early adolescent stress

Neuroscience Research, Journal Year: 2021, Volume and Issue: 172, P. 63 - 72

Published: April 24, 2021

Exposure to early stressful events increases susceptibility post-traumatic stress disorder (PTSD) in adulthood, which the hypothalamic-pituitary-adrenal (HPA) axis plays a crucial role. Studies have found that environmental enrichment (EE) mitigates detrimental outcomes of adversity. However, HPA-related mechanism remains unclear. In this study, we used single prolonged (SPS) paradigm explore long-term effects adolescent on behavior, HPA activity, as well expression levels glucocorticoid receptor (GR), mineralocorticoid (MR), corticotropin-releasing hormone 1 (CRF1R) and CRF2R hypothalamus hippocampus. Meanwhile, protective EE intervention were examined. We adult male rats exposed showed reduced locomotor increased anxiety-like behaviors, enhanced contextual fear memory, elevated basal plasma ACTH levels, negative feedback inhibition, indicated by decreased dexamethasone suppression test (DST). Furthermore, normalized behavioral abnormalities stressed rats, possibly through down-regulating GR hippocampus hypothalamus. These findings suggested could ameliorate stress-induced PTSD-like behaviors aberrant reprogramming axis, reducing risk developing PTSD adulthood.

Language: Английский

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Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review

Pharmacology Biochemistry and Behavior, Journal Year: 2022, Volume and Issue: 221, P. 173471 - 173471

Published: Oct. 10, 2022

Language: Английский

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The influence of long-term housing in enriched environment on behavior of normal rats and subjected to neonatal pro-inflammatory challenge

Brain Behavior & Immunity - Health, Journal Year: 2023, Volume and Issue: 30, P. 100639 - 100639

Published: May 24, 2023

It is well known that neonatal pro-inflammatory challenge (NPC) acquire a predisposition to the development of number neuropsychiatric diseases: depression, anxiety disorders, autism, attention deficit hyperactivity disorder. Symptoms these diseases can manifest themselves in adulthood and adolescent after repeated exposure negative influences. Preventing consequences NPC one main tasks for researchers. The an enriched environment (EE) was shown have anxiolytic, anti-depressive, pro-cognitive effects. present work aimed investigate effects long-term EE on anxious-depressive conditioned fear behavior normal male female rats subjected NPC. induced by subcutaneous administration lipopolysaccharide (LPS, 50 μg/kg) 3d 5th PNDs. control animals received saline (SAL). were placed from 25 120 PND. Animals housed standard conditions (STAND) served as controls. In adult STAND groups, LPS did not affect anxiety, depressive-like fear. increased motor search activity males females. open field, reduced SAL groups females compared animals. elevated plus maze, decreased only group. sucrose preference test, change consumption while, forced swimming both groups. enrichment contextual but group, cue corticosterone reactivity stress basal level IL-1beta blood serum SAL-EE Thus, males, females, Although behaviors prevented beneficial opposing dependent sex type testing.

Language: Английский

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