The Zinc-Copper Connection In Autism Spectrum Disorder: Pioneering Work Of Dr. Geir Bjørklund DOI Open Access
Yuliya Semenova

Ars medica tomitana, Journal Year: 2023, Volume and Issue: 29(4), P. 245 - 257

Published: Nov. 1, 2023

Abstract This interview delves into the relationship between zinc (Zn) and copper (Cu) in autism spectrum disorder (ASD), featuring insights from Dr. Geir Bjørklund, MD, a Norwegian researcher. Collaborative studies conducted across diverse countries, including China, Slovenia, Romania, Russia, Brazil, Egypt, consistently reveal altered Zn Cu levels individuals with ASD. These findings suggest potential correlation elevated increased severity of ASD symptoms. Bjørklund emphasizes multifaceted dynamics metallothioneins (MTs), essential proteins for metal binding detoxification, their association deficiency individuals. The illuminates balance within GABAergic system, implicating these trace elements synaptic modulation broader neurobiological functions. Future research directions proposed by encompass exploring multiple biological mediums accurate element assessment, investigating interactions different elements, factors influencing various tissues. significance supplementation treating ASD, implications MT dysfunction, importance dual monitoring during therapy are thoroughly discussed. conclusion expresses gratitude Bjørklund’s invaluable contributions to comprehending role highlighting global relevance his need comprehensive approach understanding this complex neurodevelopmental disorder.

Language: Английский

Update of the risk assessment of inorganic arsenic in food DOI Creative Commons

Dieter Schrenk,

Margherita Bignami,

Laurent Bodin

et al.

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 1, 2024

The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard of inorganic (iAs) and using the revised exposure issued by 2021. Epidemiological studies show that chronic intake iAs via diet and/or drinking water is associated with increased several adverse outcomes including cancers skin, bladder lung. CONTAM Panel used benchmark dose lower confidence limit based response (BMR) 5% (relative increase background incidence after adjustment for confounders, BMDL05) 0.06 μg iAs/kg bw per day obtained from study skin cancer as Reference Point (RP). Inorganic As genotoxic carcinogen additional epigenetic effects applied margin (MOE) approach characterisation. In adults, MOEs are low (range between 2 0.4 mean consumers 0.9 0.2 at 95th percentile exposure, respectively) such raise health concern despite uncertainties.

Language: Английский

Citations

61
Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications DOI Open Access
Łukasz Bryliński, Katarzyna Kostelecka, Filip Woliński

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7228 - 7228

Published: April 13, 2023

Aluminium (Al) is the most ubiquitous metal in Earth’s crust. Even though its toxicity well-documented, role of Al pathogenesis several neurological diseases remains debatable. To establish basic framework for future studies, we review literature reports on toxicokinetics and Alzheimer’s disease (AD), autism spectrum disorder (ASD), alcohol use (AUD), multiple sclerosis (MS), Parkinson’s (PD), dialysis encephalopathy (DE) from 1976 to 2022. Despite poor absorption via mucosa, biggest amount comes with food, drinking water, inhalation. Vaccines introduce negligible amounts Al, while data skin (which might be linked carcinogenesis) limited requires further investigation. In above-mentioned diseases, shows excessive accumulation central nervous system (AD, AUD, MS, PD, DE) epidemiological links between greater exposition their increased prevalence DE). Moreover, suggests that has potential as a marker PD) beneficial results chelator (such cognitive improvement AD, DE cases).

Language: Английский

Citations

43
Association between heavy metals exposure (cadmium, lead, arsenic, mercury) and child autistic disorder: a systematic review and meta-analysis DOI Creative Commons

Mengmeng Ding,

Shanshan Shi, Shuyan Qie

et al.

Frontiers in Pediatrics, Journal Year: 2023, Volume and Issue: 11

Published: July 4, 2023

Background Studies have found that toxic heavy metals exposure could induce the generation of reactive oxygen species (ROS), and is epigenetic effect, which might be associated with occurrence Autistic Disorder (ASD). This systematic review meta-analysis aims to elucidate association between 4 metals, cadmium (Cd), lead (Pb), arsenic(As), mercury (Hg), ASD in children. Methods We searched PubMed, Web Science, Embase, Cochrane Library, from their inception October 2022, for epidemiological investigations explore Cd, Pb, As, or Hg child ASD. Results A total 53 studies were included, involving 5,054 individuals aged less than 18 (2,533 patients 2,521 healthy controls). Compared controls, hair blood tests, concentrations significantly higher group control group, differences arsenic statistically significant ( P < 0.05). In urine test, 0.05), while results Cd Pb opposite those > Subgroup analysis geographic regions showed Asia Europe had compared arsenic, North America, controls Conclusion Hg. These play different roles progression Moreover, there heterogeneity among included due controversies about study countries sources detection materials. The this firmly support policies limit exposure, especially pregnant women young children, so as help reduce incidence

Language: Английский

Citations

34
Mercury exposure and childhood outcomes: an overview of systematic reviews DOI Creative Commons
Lauren E. O’Connor, Maureen K Spill, Rupal Trivedi

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121196 - 121196

Published: Feb. 1, 2025

Language: Английский

Citations

1
An ecological study shows increased prevalence of autism spectrum disorder in children living in a heavily polluted area DOI Creative Commons

Annamaria Moschetti,

Manuela Giangreco, Luca Ronfani

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 26, 2024

The burden of autism spectrum disorder (ASD) is increasing worldwide with genetic, epigenetic, and environmental factors being possibly responsible for the observed epidemiological figures. In setting exposure, city Taranto, in Southern Italy, represents an interesting case study as it hosts well inside one biggest steel plants Europe. This a cross-sectional ecological carried out year 2020 province Taranto designed to estimate ASD municipalities Statte, classified high risk areas (Contaminated Site National Interest—SIN), compared other 27 same province. Differences have been evaluated using Chi Square Test. Children aged 6–11 years identified SIN had statistically significant higher prevalence than children (9.58 vs. 6.66/1000 respectively, p = 0.002). No difference was 12–18 group (3.41 2.54/1000, 0.12). findings this are suggestive association between urban residential proximity industrial facilities emitting air pollutants prevalence.

Language: Английский

Citations

6
A systematic literature review on the association between exposures to toxic elements and an autism spectrum disorder DOI

Amir Shiani,

Kiomars Sharafi, Abdullah Khalid Omer

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 857, P. 159246 - 159246

Published: Oct. 8, 2022

Language: Английский

Citations

27
Environmental pollutants as risk factors for autism spectrum disorders: a systematic review and meta-analysis of cohort studies DOI Creative Commons
Tatiana Duque-Cartagena, Marcello Dala Bernardina Dalla, Eduardo Mundstock

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 3, 2024

Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental condition affecting communication, social interaction, and behavior. Evidence suggests that environmental pollutants are associated with ASD incidence. This review aimed to analyze the effect of on ASD. Systematic meta-analysis cohort studies evaluated association between exposure We searched COCHRANE CENTRAL, MEDLINE, CINAHL, LILACS, EMBASE, PsycINFO, Web Science, SciELO, gray literature from inception January 2023. The model used for was inverse variance heterogeneity (IVhet). measures were beta coefficient (β) relative risk (RR) their 95% confidence intervals (95% CI). Sensitivity analyses carried out using an instrument screen or diagnose autism. A total 5,780 identified; 27 included in systematic review, 22 meta-analysis. These 1,289,183 participants 129 pollutants. Individual meta-analyses found significant nitrogen dioxide RR = 1.20 CI: 1.03 1.38; I2: 91%), copper 1.08 1.13; 0%), mono-3-carboxy propyl phthalate β 0.45 0.20 0.70; monobutyl 0.43 0.13 0.73; 0%) polychlorinated biphenyl (PCB) 138 1.84 1.14 2.96; I2:0%) Subgroup carbon monoxide 1.57 1.25 1.97; oxides 1.09 1.04 1.15; 34%) metals 1.13 1.01 1.27; I2:24%). study positive associations dioxide, copper, mono-3-carboxypropyl phthalate, PCB 138, development ASD, likewise, subgroups monoxide, oxides, metals. Therefore, it important identify these factors children adolescents contribute prevention strategies effectively.

Language: Английский

Citations

4
Exposure to air pollution from coal-fired power plants and impacts on human health: a scoping review DOI Creative Commons
Nomfundo Mahlangeni, Thandi Kapwata, Candice Webster

et al.

Reviews on Environmental Health, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Communities living in proximity to coal-fired power plants (CFPPs) may be at greater risk of negative health impacts from exposure air pollution than communities further away. The aim this scoping review was provide an update on the evidence risks associated with CFPPs and evaluate relationship between residential extent burden. We followed PRISMA-ScR guidelines searched Google Scholar, PubMed, ScienceDirect, Scopus Web Science for relevant studies inception up 31 January 2024. Fifty-six were included most articles published 2016 2023 (n=33, 59 %) 35 high income countries (63 %). Living close frequently increased odds or likelihood respiratory disorders, adverse birth outcomes child developmental issues. Interventions such as emission control systems total shutdown led improved among near CFPPs. highlights need policy measures reduce by installing technologies transitioning cleaner energy sources.

Language: Английский

Citations

0
Association between urinary toxic and essential metals exposure and autism in children DOI Creative Commons
Sharanpreet Kaur, Josefa Canals, Paula Morales‐Hidalgo

et al.

Published: May 5, 2025

Language: Английский

Citations

0
Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis DOI Creative Commons
Aleksandar Stojsavljević,

Novak Lakićević,

Slađan Pavlović

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(12), P. 3344 - 3344

Published: Dec. 18, 2023

Mercury (Hg) is a non-essential trace metal with unique neurochemical properties and harmful effects on the central nervous system. In this study, we present comprehensive review meta-analysis of peer-reviewed research encompassing five crucial clinical matrices: hair, whole blood, plasma, red blood cells (RBCs), urine. We assess disparities in Hg levels between gender- age-matched neurotypical children (controls) diagnosed autism spectrum disorder (ASD) (cases). After applying rigorous selection criteria, incorporated total 60 case-control studies into our meta-analysis. These comprised 25 investigations hair (controls/cases: 1134/1361), 15 1019/1345), 6 plasma 224/263), 5 RBCs 215/293), 9 urine 399/623). This did not include data ASD who received chelation therapy. Our revealed no statistically significant differences cases controls. RBCs, were significantly higher compared to their counterparts. indicates that could exhibit reduced detoxification capacity for impaired mechanisms excretion from bodies. underscores detrimental role critical importance monitoring children, particularly early childhood. findings emphasize pressing need global initiatives aimed at minimizing exposure, thus highlighting intersection human-environment interaction neurodevelopment health.

Language: Английский

Citations

8