Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 107 - 125
Published: Jan. 1, 2024
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 491, P. 137832 - 137832
Published: March 6, 2025
Language: Английский
Citations
2
International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(2), P. 1004 - 1004
Published: Jan. 5, 2023
Heavy metal pollution related to non-ferrous smelting may pose a significant threat human health. This study analyzed 58 surface soils collected from representative area screen potentially hazardous heavy metals and evaluate their health risk in the studied area. The findings demonstrated that activity had contributed degrees of Cu, Cd, As, Zn, Pb surrounding plant (NMSP). Pb, Ni, Co within NMSP was serious. Combining spatial distribution Spearman correlations with principal component analysis (PCA), primary sources Zn areas were transportation activities. High non-cancer (THI = 4.76) cancer risks (TCR 2.99 × 10−4) found for adults NMSP. Moreover, posed potential children 3.62 10−6) 1.27 10−5). contributions Cd requires special attention. construction management system will benefit current industry.
Language: Английский
Citations
18
Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(46), P. 18139 - 18150
Published: Aug. 18, 2023
A growing body of literature suggests that developmental exposure to individual or mixtures environmental chemicals (ECs) is associated with autism spectrum disorder (ASD). However, investigating the effect interactions among these ECs can be challenging. We introduced a combination classical exposure-mixture Weighted Quantile Sum (WQS) regression and machine-learning method termed Signed iterative Random Forest (SiRF) discover synergistic between are (1) higher odds ASD diagnosis, (2) mimic toxicological interactions, (3) present only in subset sample whose chemical concentrations than certain thresholds. In case-control Childhood Autism Risks from Genetics Environment (CHARGE) study, we evaluated multiordered 62 measured urine samples 479 children association increased for diagnosis (yes vs no). WQS-SiRF identified two two-ordered trace-element cadmium (Cd) organophosphate pesticide metabolite diethyl-phosphate (DEP); 2,4,6-trichlorophenol (TCP-246) DEP. Both were suggestively urinary Cd, DEP, TCP-246 above 75th percentile. This study demonstrates novel combines inferential power WQS predictive accuracy algorithms potentially biologically relevant chemical–chemical ASD.
Language: Английский
Citations
15
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 26, 2024
The burden of autism spectrum disorder (ASD) is increasing worldwide with genetic, epigenetic, and environmental factors being possibly responsible for the observed epidemiological figures. In setting exposure, city Taranto, in Southern Italy, represents an interesting case study as it hosts well inside one biggest steel plants Europe. This a cross-sectional ecological carried out year 2020 province Taranto designed to estimate ASD municipalities Statte, classified high risk areas (Contaminated Site National Interest—SIN), compared other 27 same province. Differences have been evaluated using Chi Square Test. Children aged 6–11 years identified SIN had statistically significant higher prevalence than children (9.58 vs. 6.66/1000 respectively, p = 0.002). No difference was 12–18 group (3.41 2.54/1000, 0.12). findings this are suggestive association between urban residential proximity industrial facilities emitting air pollutants prevalence.
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 10, 2024
Medicinal plants (MPs) have long been used for their therapeutic properties in traditional forms of medicine. However, the presence potentially toxic elements (PTEs) MPs raises concerns about safety, efficacy, and potential adverse effects on human health. The current study aimed to determine level essential (PTEEs) commonly consumed Zabol, Iran, along with health risk assessments. To conduct present study, 10 types widely were selected, 15 samples each type (150 total) taken. Each sample was analyzed various PTEEs using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) Lead (Pb), cadmium (Cd), chrome (Cr), nickel (Ni), copper (Cu), zinc (Zn), iron (Fe), aluminum (Al) manganese (Mn); Atomic Absorption Spectrometry (AAS) arsenic (As) mercury (Hg). Finally, better comprehend scope exposure its possible effects, Monte Carlo simulation method is successfully applied assess risks related PTEs MPs. Statistical analysis revealed statistically significant (P < 0.001) variations PTE averages among MP types. Furthermore, all samples' overall mean concentration (range: 0.18 215.5 µg/kg) below World Health Organization's (WHO) regulatory standards. Probabilistic risks, including non-carcinogenic-target hazard quotient (THQ) element, total target (TTHQ) elements, carcinogenic-incremental lifetime cancer (ILCR) carcinogenic (TCR) significantly lower than acceptable limit children adults. Accordingly, it can be said that consuming sold Zabol safe adults regarding (ILCR/TCR =
Language: Английский
Citations
4
Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 282 - 282
Published: April 8, 2025
Rapid industrialization has introduced a range of chemicals into the environment, posing significant risks to fetal and child brain development. Using Comparative Toxicogenomics Database (CTD), we constructed chemical exposome frameworks for seven neurodevelopmental disorders (NDDs) identified pollutants epidemiological concern, including air (n = 8), toxic elements 14), pesticides related compounds 18), synthetic organic 16), solvents 5). Gene set enrichment analysis validated revealed toxicogenomic associations between these NDDs, autism spectrum disorder (ASD) (12 pollutants, proportional reporting ratio (PRR) 3.56–7.21) intellectual disability (ID) (9 PRR 3.13–5.59). Functional annotation pollutant-specific gene sets highlighted shared biological processes, such as metabolic processes (e.g., xenobiotic process, catabolic cytochrome P450 pathway) ASD cognitive cognition, social behavior, synapse assembly) ID (Bonferroni-corrected p-values < 0.05). Time trajectory developmental transcriptomic data from BrainSpan database (275 genes) (93 three distinct expression patterns chemical-pollutant-associated genes—higher prenatal, postnatal, perinatal expression—indicating common divergent underlying mechanisms across critical windows pollutant exposure.
Language: Английский
Citations
0
Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121547 - 121547
Published: April 1, 2025
Language: Английский
Citations
0
Biomedicines, Journal Year: 2023, Volume and Issue: 11(12), P. 3344 - 3344
Published: Dec. 18, 2023
Mercury (Hg) is a non-essential trace metal with unique neurochemical properties and harmful effects on the central nervous system. In this study, we present comprehensive review meta-analysis of peer-reviewed research encompassing five crucial clinical matrices: hair, whole blood, plasma, red blood cells (RBCs), urine. We assess disparities in Hg levels between gender- age-matched neurotypical children (controls) diagnosed autism spectrum disorder (ASD) (cases). After applying rigorous selection criteria, incorporated total 60 case-control studies into our meta-analysis. These comprised 25 investigations hair (controls/cases: 1134/1361), 15 1019/1345), 6 plasma 224/263), 5 RBCs 215/293), 9 urine 399/623). This did not include data ASD who received chelation therapy. Our revealed no statistically significant differences cases controls. RBCs, were significantly higher compared to their counterparts. indicates that could exhibit reduced detoxification capacity for impaired mechanisms excretion from bodies. underscores detrimental role critical importance monitoring children, particularly early childhood. findings emphasize pressing need global initiatives aimed at minimizing exposure, thus highlighting intersection human-environment interaction neurodevelopment health.
Language: Английский
Citations
8
Chemosphere, Journal Year: 2023, Volume and Issue: 330, P. 138700 - 138700
Published: April 17, 2023
Language: Английский
Citations
7
Critical Reviews in Toxicology, Journal Year: 2024, Volume and Issue: 54(3), P. 174 - 193
Published: March 15, 2024
An association between exposure to arsenic (As) and neurologic behavioral effects has been reported in some studies, but no systematic review is available of the evidence linking As drinking water neurobehavioral after consideration study quality potential confounding, with focus on low-level circumstances exposure. We conducted a it compliance Preferred Reporting Items for Systematic reviews Meta-Analyses (PRISMA) guidelines, through search databases PubMed, Web Science, Scopus, Embase. included studies reporting results based from humans. Endpoints were heterogeneous across so we classified them into eight broad domains developed an ad-hoc system evaluate their methodological quality, three tiers. It was not possible conduct meta-analysis because heterogeneity assessment definition outcomes. The identified 18,518 articles. After elimination duplicates irrelevant articles, retained 106 articles which effects, 22 risk estimates (six among adults 16 children). None blindly. Among adults, two, highly exposed populations, as high quality. These two broadly consistent decline cognitive function; however, they provide below 75 μg/L. four lower-quality populations low exposure; these associations inconsistent outcomes, few remained statistically significant adjustment multiple comparisons. five high-quality children, one intellectual function, whereas none other different indicators, adjusting confounders Out seven intermediate-quality function or outcomes; sources bias adequately controlled. remaining negative. low-quality did contribute overall limitations. Our literature showed lack causal effects. To clarify whether such exists, further prospectively evaluating changes both concentration during life course, well appropriately controlling confounders, are needed.
Language: Английский
Citations
2