Application of Caenorhabditis elegans in the evaluation of food nutrition: A review DOI Creative Commons

Quancen Li,

Meifang Xiao,

Na Li

et al.

eFood, Journal Year: 2023, Volume and Issue: 4(1)

Published: Feb. 1, 2023

Abstract At present, more and people are suffering from various diseases it is particularly important to find a suitable biological model evaluate the prevention treatment effects of drugs active ingredients on diseases. In all models, Caenorhabditis elegans kind organism that easy observe cultivate, has clear genetic background high degree signal pathway conservation with humans. A variety such as polyphenols, polysaccharides, polypeptides, vitamins exist natural products, which extremely physiological functions medicinal values. It highly reliable trophic functional properties products in C. . The antiaging, anti‐oxidation, regulating lipid metabolism, preventing treating Alzheimer's disease were clarified this review. same time, its possible pathways summarized. literature revealed had great effect nutrition functionality Finally, shortcomings field suggestions for further improvement have been emphasized.

Language: Английский

Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans DOI
Huimin Liu, Ying Wang, Wei‐Ping Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 202, P. 286 - 295

Published: Jan. 15, 2022

Language: Английский

Citations

35
Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila DOI Creative Commons
Mami Nakamizo-Dojo, Kenichi Ishii, Jiro Yoshino

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 16, 2023

Although painful stimuli elicit defensive responses including escape behavior for survival, starved animals often prioritize feeding over even in a noxious environment. This behavioral priority is typically mediated by suppression of inputs through descending control the brain, yet underlying molecular and cellular mechanisms are incompletely understood. Here we identify cluster GABAergic neurons Drosophila larval designated as SEZ-localized Descending (SDGs), that project axons onto axon terminals peripheral nociceptive prevent presynaptic activity GABAB receptors. Remarkably, glucose to larvae causes sustained activation SDGs glucose-sensing subsequent insulin signaling SDGs, which attenuates nociception thereby suppresses response multiple stimuli. These findings illustrate neural mechanism sugar sensing brain engages gating achieve hierarchical interaction between behavior.

Language: Английский

Citations

20
Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans DOI Creative Commons
Majdulin Nabil Istiban, Nathan De Fruyt, Signe Kenis

et al.

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 584, P. 112162 - 112162

Published: Jan. 28, 2024

Peptides and protein hormones form the largest group of secreted signals that mediate intercellular communication are central regulators physiology behavior in all animals. Phylogenetic analyses biochemical identifications peptide-receptor systems reveal a broad evolutionary conservation these signaling at molecular level. Substantial progress has been made recent years on characterizing physiological putative ancestral roles many peptide through comparative studies invertebrate models. Several peptides not only molecularly conserved but also have across animal phyla. Here, we focus functional insights gained nematode Caenorhabditis elegans that, with its compact well-described nervous system, provides powerful model to dissect neuroendocrine networks involved control behavior. We summarize discoveries knowledge functions hormone C. elegans.

Language: Английский

Citations

7
C. elegans insulin-like peptides DOI Creative Commons

Rain Zhu,

Ian D. Chin-Sang

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 585, P. 112173 - 112173

Published: Feb. 11, 2024

Insulin-like peptides are a group of hormones crucial for regulating metabolism, growth, and development in animals. Invertebrates, such as C. elegans, have been instrumental understanding the molecular mechanisms insulin-like peptides. Here, we review 40 peptide genes encoded elegans genome. Despite large number, there is only one receptor, called DAF-2. The insulin growth factor signaling (IIS) pathway evolutionarily conserved from worms to humans. Thus provides an excellent model understand how these function. unique that it possesses antagonistic properties, unlike all human peptides, which agonists. This overview current literature on structures, processing, tissue localization, regulation. We will also provide examples during development, germline learning/memory, longevity.

Language: Английский

Citations

6
Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior DOI Creative Commons
Jan Watteyne,

Aleksandra Chudinova,

Lidia Ripoll-Sánchez

et al.

Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract Neuropeptides are abundant signaling molecules that control neuronal activity and behavior in all animals. Owing part to its well-defined compact nervous system, Caenorhabditis elegans has been one of the primary model organisms used investigate how neuropeptide networks organized these neurochemicals regulate behavior. We here review recent work expanded our understanding neuropeptidergic network C. by mapping evolutionary conservation, molecular expression, receptor–ligand interactions, system-wide organization pathways system. also describe general insights into circuit motifs spatiotemporal range peptidergic transmission have emerged from vivo studies on signaling. With efforts ongoing chart peptide other organisms, connectome can serve as a prototype further understand dynamics at organismal level.

Language: Английский

Citations

6
From worms to humans: Understanding intestinal lipid metabolism via model organisms DOI Creative Commons
Darby W. Kozan, Joshua T. Derrick, William B. Ludington

et al.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2023, Volume and Issue: 1868(4), P. 159290 - 159290

Published: Feb. 3, 2023

Language: Английский

Citations

13
Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion DOI Creative Commons

Amanda J González Segarra,

Gina Pontes, Nicholas Jourjine

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Sept. 21, 2023

Consumption of food and water is tightly regulated by the nervous system to maintain internal nutrient homeostasis. Although generally considered independently, interactions between hunger thirst drives are important coordinate competing needs. In Drosophila , four neurons called interoceptive subesophageal zone (ISNs) respond intrinsic signals oppositely regulate sucrose ingestion. Here, we investigate neural circuit downstream ISNs examine how ingestion based on Utilizing recently available fly brain connectome, find that synapse with a novel cell-type bilateral T-shaped neuron (BiT) projects neuroendocrine centers. vivo manipulations revealed BiT regulates sugar Neuroendocrine cells include several peptide-releasing peptide-sensing neurons, including insulin producing (IPCs), crustacean cardioactive peptide (CCAP) CCHamide-2 receptor isoform RA (CCHa2R-RA) neurons. These contribute differentially water, IPCs CCAP regulating ingestion, CCHa2R-RA modulating only Thus, decision consume or occurs via regulation broad peptidergic network integrates nutritional state generate nutrient-specific

Language: Английский

Citations

13
Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion DOI Creative Commons

Amanda J González Segarra,

Gina Pontes, Nicholas Jourjine

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: June 15, 2023

Consumption of food and water is tightly regulated by the nervous system to maintain internal nutrient homeostasis. Although generally considered independently, interactions between hunger thirst drives are important coordinate competing needs. In Drosophila , four neurons called interoceptive subesophageal zone (ISNs) respond intrinsic signals oppositely regulate sucrose ingestion. Here, we investigate neural circuit downstream ISNs examine how ingestion based on Utilizing recently available fly brain connectome, find that synapse with a novel cell-type bilateral T-shaped neuron (BiT) projects neuroendocrine centers. vivo manipulations revealed BiT regulates sugar Neuroendocrine cells include several peptide-releasing peptide-sensing neurons, including insulin producing (IPCs), crustacean cardioactive peptide (CCAP) CCHamide-2 receptor isoform RA (CCHa2R-RA) neurons. These contribute differentially water, IPCs CCAP regulating ingestion, CCHa2R-RA modulating only Thus, decision consume or occurs via regulation broad peptidergic network integrates nutritional state generate nutrient-specific

Language: Английский

Citations

12
Effects of molting on the expression of ecdysteroid responsive genes in the crustacean molting gland (Y-organ) DOI
Samiha A. M. Benrabaa,

Sharon A. Chang,

Ernest S. Chang

et al.

General and Comparative Endocrinology, Journal Year: 2024, Volume and Issue: 355, P. 114548 - 114548

Published: May 16, 2024

Language: Английский

Citations

5
Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism DOI
Anna Castells‐Nobau, José María Moreno‐Navarrete, Lisset de la Vega-Correa

et al.

Gut, Journal Year: 2024, Volume and Issue: unknown, P. gutjnl - 332602

Published: Oct. 2, 2024

The microbiota is emerging as a key factor in the predisposition to insulin resistance and obesity.

Language: Английский

Citations

5