Sustainable Food Proteins,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 12, 2024
Abstract
Bioactive
peptides
that
are
derived
through
the
enzymatic
hydrolysis
of
proteins
have
garnered
significant
attention
for
their
diverse
health‐promoting
properties.
This
article
delves
into
technology
behind
plant‐derived
bioactive
peptide
production
by
emphasizing
principles
enzyme
hydrolysis.
Furthermore,
review
highlights
refinement
techniques,
employing
membrane
ultrafiltration
and
various
forms
column
chromatography
to
isolate
purify
these
effectively.
The
properties
protein
hydrolysates
encompass
a
range
health
benefits,
including
antihypertensive,
antioxidant,
anti‐diabetic,
anti‐obesity,
neuroprotective
effects.
Additionally,
demonstrate
promise
in
inhibiting
cancer
cell
growth,
supporting
bone
health,
modulating
immune
responses.
These
hold
immense
potential
revolutionizing
approaches
conditions.
Continued
research
this
field
promises
further
insights
breakthroughs,
propelling
forefront
nutrition
healthcare
innovation.
convergence
advanced
multifaceted
bioactivity
present
an
exciting
avenue
improving
human
well‐being
addressing
wide
array
challenges.
Journal of Future Foods,
Journal Year:
2022,
Volume and Issue:
2(2), P. 143 - 159
Published: May 26, 2022
Plant
proteins
are
good
alternative
to
animal
sources
in
bioactive
peptide
production
due
their
safety,
low-cost,
rich
resources
and
easy
for
large
scale
production.
The
bioactivities
of
the
peptides
derived
from
plant
including
antihypertensive,
hypocholesterolemic,
immunomodulatory,
antioxidant,
antimicrobial,
anti-diabetic,
opiate
hepatoprotective
effect
being
increasingly
recognized
with
regards
health
promoting
disease
prevention.
In
addition
bioactivities,
plant-derived
possess
various
functional
properties
emulsifying
foaming
properties,
water
oil
retention
capacities
owning
hydrophilic/lipophilic
property,
conformational
flexibility
chain
length
peptides.
Hence,
promising
ingredients
development
health-care
products.
This
review
provides
research
progress
on
biological
activities
mechanism
action
structure-activity
relationships
were
also
described,
when
known.
Furthermore,
recent
developments,
major
challenges
prospect
application
plant-derive
products
discussed
summarized.
objective
this
is
improve
understanding
peptides,
provide
some
constructive
inspirations
further
industrial
food
medicine
industry.
Nucleic Acids Research,
Journal Year:
2023,
Volume and Issue:
51(W1), P. W432 - W437
Published: May 11, 2023
Abstract
Accurate
and
fast
structure
prediction
of
peptides
less
40
amino
acids
in
aqueous
solution
has
many
biological
applications,
but
their
conformations
are
pH-
salt
concentration-dependent.
In
this
work,
we
present
PEP-FOLD4
which
goes
one
step
beyond
machine-learning
approaches,
such
as
AlphaFold2,
TrRosetta
RaptorX.
Adding
the
Debye-Hueckel
formalism
for
charged-charged
side
chain
interactions
to
a
Mie
all
intramolecular
(backbone
chain)
interactions,
PEP-FOLD4,
based
on
coarse-grained
representation
peptides,
performs
well
methods
well-structured
displays
significant
improvements
poly-charged
peptides.
is
available
at
http://bioserv.rpbs.univ-paris-diderot.fr/services/PEP-FOLD4.
This
server
free
there
no
login
requirement.
Smart Medicine,
Journal Year:
2023,
Volume and Issue:
2(2)
Published: Feb. 16, 2023
Stimuli-responsive
"smart"
hydrogel
biomaterials
have
attracted
great
attention
in
the
biomedical
field,
especially
designing
novel
on-demand
drug
delivery
systems.
As
a
handful
natural
biomaterial
approved
by
US
Food
and
Drug
Administration,
silk
fibroin
(SF)
has
unique
high
temperature
resistance
as
well
tunable
structural
composition.
These
properties
make
it
one
of
most
ideal
candidates
for
delivery.
Meanwhile,
recent
advances
polymer
modification
nanomaterials
fostered
development
various
stimuli-responsive
Here,
we
first
review
advance
responsive
SF-based
systems
different
stimulus
sources.
are
able
to
release
mediators
desired
manner
response
specific
stimuli
active
or
passive
manners.
We
then
describe
applications
these
specially
designed
wound
healing,
tumor
therapy,
immunomodulation.
also
discuss
future
challenges
prospects
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 24, 2024
Cancer
is
still
considered
a
lethal
disease
worldwide
and
the
patients’
quality
of
life
affected
by
major
side
effects
treatments
including
post-surgery
complications,
chemo-,
radiation
therapy.
Recently,
new
therapeutic
approaches
were
globally
for
increasing
conventional
cancer
therapy
efficacy
decreasing
adverse
effects.
Bioactive
peptides
obtained
from
plant
animal
sources
have
drawn
increased
attention
because
their
potential
as
complementary
This
review
presents
contemporary
examination
bioactive
derived
natural
origins
with
demonstrated
anticancer,
ant
invasion,
immunomodulation
properties.
For
example,
common
beans,
chickpeas,
wheat
germ,
mung
beans
exhibited
antiproliferative
toxic
on
cells,
favoring
cell
cycle
arrest
apoptosis.
On
other
hand,
marine
showed
inhibiting
tumor
growth
metastasis.
In
this
we
will
discuss
these
data
highlighting
befits
need
further
investigations
to
fully
characterize
in
clinics.
Current Pharmaceutical Design,
Journal Year:
2023,
Volume and Issue:
29(9), P. 652 - 674
Published: Feb. 2, 2023
Bioactive
peptides
are
specific
protein
fragments
that
prove
health-promoting
potential
for
humans.
The
bioactivities
include
antimicrobial,
antioxidant,
anticancer,
immunomodulatory
activities,
etc.
Hence,
bioactive
peptides'
production
technology
and
processes
have
attracted
excessive
attention,
especially
concerning
synthesis,
separation,
identification,
functionality.
This
review
summarizes
the
relevant
investigations
from
above
four
aspects.
Among
of
peptides,
biosynthesis,
chemosynthesis,
separation
purification,
interactions
responsible
peptide-based
nanostructures
emphasized.
Here,
biosynthesis
includes
enzymatic
hydrolysis,
microbial
fermentation,
recombinant
DNA
technology,
chemosynthesis
consists
solution-phase
peptide
synthesis
solid-phase
(SPPS).
commonly
used
enzymes
in
hydrolysis
investigated,
including
pepsin,
trypsin,
alcalase.
microorganisms,
typical
processes,
sources,
advantages
fermentation
analyzed.
Membrane
(including
ultrafiltration
nanofiltration),
chromatography
ion-exchange
chromatography,
gel
filtration
affinity
reverse-phase
high-performance
liquid
(RP-HPLC)),
electrophoresis
detailed
purification
technology.
Mass
spectrometry
(MS),
its
combination
with
method,
nuclear
magnetic
resonance
(NMR)
elucidated
identification
non-covalent
involve
electrostatic
force,
hydrogen
bonds,
π-π
stacking,
hydrophobic
interaction,
van
der
Waals
force.
Afterward,
we
detail
antihypertensive,
antithrombotic,
activities.
activity
analysis
mainly
involves
structural
features,
mechanisms
action,
influencing
factors.
Based
on
functionality
elucidation,
challenges
application
biomedicine
given.
challenge
is
analyzed
aspects
technologies
factors
bioactivities.
Our
work
will
elaborate
advances
their
bioactivities,
which
could
promote
expand
industrial
applications.
Frontiers in Sustainable Food Systems,
Journal Year:
2024,
Volume and Issue:
8
Published: April 10, 2024
Plant
proteins
have
been
considered
a
potential
source
of
bio-functional
peptides,
which
can
be
beneficial
for
human
health.
The
potent
antioxidant
properties
plant-based
peptides
protect
against
oxidative
damage
and
associated
diseases.
Despite
significant
number
studies
on
the
preparation
biological
functions
only
limited
are
commercially
utilized.
systematic
extraction,
optimization,
isolation,
pharmacokinetics,
stability,
safety
aspects
plant
protein-derived
(PPDP)
in
progress.
Also,
molecular
mechanism
action
health
benefits
bioactive
PPDP
is
still
lacking.
Hence,
this
review
provides
comprehensive
discussion
various
protein
sources
to
end-product
applications
PPDP.
In
context,
different
explored
functional
presented.
green
biotechnological
techniques
such
as
fermentation
enzymatic
hydrolysis
extraction
described.
revisited.
most
important
part
application
includes
stability
bioavailability
has
discussed.
Additionally,
impact
administration
summarized.
Lastly,
future
perspectives
concluding
remarks
documented.
European Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
195, P. 106710 - 106710
Published: Jan. 26, 2024
Silk
fibroin
is
a
fibrillar
protein
obtained
from
arthropods
such
as
mulberry
and
non-mulberry
silkworms.
has
been
used
dressing
in
wound
treatment
for
its
physical,
chemical,
mechanical,
biological
properties.
This
systematic
review
analyzed
studies
PubMed,
Web
of
Science,
Scopus
databases
to
identify
the
molecules
preferred
functionalizing
silk
fibroin-based
dressings
describe
their
mechanisms
exhibiting
anti-inflammatory
antibacterial
The
analysis
selected
articles
allowed
us
classify
into
different
conformations,
membranes,
films,
hydrogels,
sponges,
bioadhesives.
incorporation
various
molecules,
including
antibiotics,
natural
products,
peptides,
nanocomposites,
nanoparticles,
secondary
metabolites,
growth
factors,
cytokines,
development
that
promote
healing
with
immunomodulatory
In
addition,
have
established
potential
regenerate
wounds
venous
ulcers,
arterial
diabetic
foot,
third-degree
burns,
neoplastic
ulcers.
Evaluation
efficacy
tissue
engineering
an
area
great
activity
shown
significant
advances
recent
years.
