Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155169 - 155169
Published: Oct. 28, 2023
Language: Английский
Redox Biology, Journal Year: 2022, Volume and Issue: 57, P. 102511 - 102511
Published: Oct. 14, 2022
Natural antioxidants represented by quercetin have been documented to be effective against atherosclerosis. However, the related mechanisms remain largely unclear. In this study, we identified a novel anti-atherosclerotic mechanism of inhibiting macrophage pyroptosis activating NRF2 through binding Arg483 site KEAP1 competitively. ApoE-/- mice fed with high fat diet, administration attenuated atherosclerosis progression reducing oxidative stress level and suppressing pyroptosis. At cellular level, suppressed THP-1 induced ox-LDL, demonstrated NLRP3 inflammasome activation ROS while these effects were reversed specific inhibitor (ML385). Mechanistically, promoted dissociate from KEAP1, enhanced nuclear translocation as well transcription downstream antioxidant protein. Molecular docking results suggested that could bind at Arg415 Arg483. order verify sites, mutated Ser (R415S R483S) was transfected into macrophages, anti-pyroptotic effect abrogated mutation, but not mutation. Furthermore, after adeno associated viral vector (AAV) AAV-KEAP1-R483S, almost abolished in mice. These findings proved quercetins targeting KEAP1/NRF2 interaction, provided reliable data on underlying natural protect
Language: Английский
Citations
72
European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)
Published: Sept. 12, 2023
Abstract Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is the major constituent of outer membrane gram-negative bacteria. Endothelial cells participate in both innate and adaptive immune responses as first cell types to detect lipopolysaccharide or other foreign debris bloodstream. are able recognize presence LPS recruit specific adaptor proteins domains TLR4, thereby initiating an intracellular signaling cascade. However, binding endothelial induces activation even damage, manifested by expression proinflammatory cytokines adhesion molecules that lead sepsis. Main findings involved local systemic inflammation, activating immunity. Translocation into circulation causes endotoxemia. dysfunction, including exaggerated coagulopathy vascular leakage, may play central role dysregulated host response pathogenesis By discussing many strategies used treat this review attempts provide overview how ever more complex syndrome sepsis potential development novel therapeutics. Conclusions To reduce patient morbidity mortality, preservation function would be management Graphical
Language: Английский
Citations
46
Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 663 - 663
Published: March 7, 2023
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles. They received considerable attention as potential therapeutic agents in biomedicine been widely used traditional complimentary medicine for generations. Such medical herbal formulations extremely complex mixtures many pharmacologically active provide outcome through network pharmacological effects complexity. Methods emerging to determine the components their targets decipher complexities how pharmacology provides such effects. The gut microbiome has important roles play generation bioactive flavonoid metabolites retaining or exceeding antioxidative anti-inflammatory properties intact and, some cases, new antitumor antineurodegenerative bioactivities. Certain food items identified with high prebiotic profiles suggesting neutraceutical supplementation may be beneficially employed preserve healthy population bacterial symbiont species minimize establishment harmful pathogenic organisms. Gut health is an consideration effecting overall wellbeing linked organ systems. Bioconversion generates can also transported by vagus nerve systemic circulation brain populations exert beneficial effect. This particularly number neurological disorders (autism, bipolar disorder, AD, PD) characterized on moods, resulting depression anxiety, impaired motor function, long-term cognitive decline. Native flavonoids alleviation inflammation tissues, however, concerns raised levels not achieved, thus allowing them display optimal Dietary manipulation vagal stimulation both yielded responses treatment autism spectrum disorders, depression, establishing route communication gut-brain axis established disease intervention. While native known penetrate blood–brain barrier, microbiome-generated (e.g., protocatechuic acid, urolithins, γ-valerolactones), which retain antioxidant potency addition promote mitochondrial cerebrovascular microcapillary should considered biotherapeutic agents. Studies warranted experimentally examine efficacy directly, they emerge novel options.
Language: Английский
Citations
42
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155472 - 155472
Published: Feb. 24, 2024
Language: Английский
Citations
20
Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)
Published: Feb. 17, 2024
Abstract Atherosclerosis, a multifaceted chronic inflammatory disease, has profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include delayed detection advanced stages, intricate assessment plaque stability, and absence efficacious therapeutic strategies. Nanotheranostic based nanotechnology offers novel paradigm for addressing these challenges by amalgamating imaging capabilities with targeted interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates theranostic applications in due to their magnetic resonance capability biosafety. This review delineates current state prospects nanoparticle‐based nanotheranostics realm atherosclerosis, including pivotal aspects development, pertinent targeting strategies involved disease pathogenesis, diagnostic roles nanoparticles. Furthermore, this provides comprehensive overview nanomedicine approaches employing nanoparticles, encompassing chemical therapy, physical stimulation biological therapy. Finally, proposes discusses associated translating innovative into clinically viable anti‐atherosclerosis In conclusion, new insights future theranostic, showcasing remarkable potential oxide‐based versatile tools battle against atherosclerosis.
Language: Английский
Citations
17
Life Sciences, Journal Year: 2021, Volume and Issue: 291, P. 120064 - 120064
Published: Oct. 21, 2021
Language: Английский
Citations
78
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113611 - 113611
Published: Sept. 5, 2022
Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges worldwide due to their high morbidity and mortality limitations in clinical treatment strategies. Studies have shown that reactive oxygen species (ROS)-mediated inflammation, excitotoxicity, programmed cell death of each neurovascular unit during post-stroke hypoxia reperfusion play an important role the pathological cascade. Ferroptosis, a characterized by iron-regulated accumulation lipid peroxidation, is caused abnormal metabolism lipids, glutathione (GSH), iron, can accelerate acute central nervous system injury. Recent studies gradually uncovered process ferroptosis stroke. Some drugs iron chelators, ferrostatin-1 (Fer-1) liproxstatin-1 (Lip-1) protect nerves after injury stroke inhibiting ferroptosis. In addition, combined with our previous on mediated natural compounds this review summarized progress regulation mechanism chemical components herbal recent years, order provide reference information for future research lead development inhibitors.
Language: Английский
Citations
57
Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(11), P. 1573 - 1590
Published: Nov. 18, 2022
Abstract Brown adipose tissue (BAT) activity contributes to cardiovascular health by its energy-dissipating capacity but how BAT modulates vascular function and atherosclerosis through endocrine mechanisms remains poorly understood. Here we show that BAT-derived neuregulin-4 (Nrg4) ameliorates in mice. BAT-specific Nrg4 deficiency accelerates inflammation adhesion responses, endothelial dysfunction apoptosis male restoration alleviates attenuates leukocyte homing reduces injury In cells, decreases apoptosis, responses induced oxidized low-density lipoprotein. Mechanistically, protein kinase B (Akt)–nuclear factor-κB signaling is involved the beneficial effects of on endothelium. Taken together, results reveal as a potential cross-talk factor between arteries may serve target for atherosclerosis.
Language: Английский
Citations
55
Nutrients, Journal Year: 2022, Volume and Issue: 14(10), P. 2161 - 2161
Published: May 23, 2022
Anthocyanins are mainly purple-coloured phenolic compounds of plant origin that as secondary metabolites important in survival. Understanding their health benefits humans requires sourcing these unstable sufficient quantities at a reasonable cost, which has led to improved methods extraction. Dark-coloured fruits, cereals and vegetables current sources compounds. The range potential sustainable is much larger includes non-commercialised native plants from around the world agri-waste containing anthocyanins. In last 5 years, there have been significant advances developing therapeutic anthocyanins chronic human diseases. exert beneficial effects through improvements gut microbiota, oxidative stress inflammation, modulation neuropeptides such insulin-like growth factor-1. Their include reduced cognitive decline; protection organs liver, well cardiovascular system, gastrointestinal tract kidneys; bone obesity; regulation glucose lipid metabolism. This review summarises some mechanisms treatment
Language: Английский
Citations
50
Journal of Ethnopharmacology, Journal Year: 2022, Volume and Issue: 288, P. 114988 - 114988
Published: Jan. 13, 2022
Language: Английский
Citations
47