Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 341 - 341
Published: Jan. 31, 2023
Adverse
pregnancy
outcomes
are
considered
significant
health
risks
for
pregnant
women
and
their
offspring
during
throughout
lifespan.
These
lead
to
a
perturbated
in-utero
environment
that
impacts
critical
phases
of
the
fetus’s
life
correlates
an
increased
risk
chronic
pathological
conditions,
such
as
diabetes,
obesity,
cardiovascular
diseases,
in
both
mother’s
adult
offspring’s
life.
The
dietary
intake
naturally
occurring
antioxidants
promotes
benefits
disease
prevention.
In
this
regard,
maternal
polyphenolic
is
linked
reduced
obesity
cardio-metabolic
disorders,
positively
affecting
fetus
offspring.
work,
we
will
gather
critically
appraise
current
literature
highlighting
effect/s
polyphenol
antioxidant
resveratrol
on
oxidative
stress,
inflammation,
other
molecular
physiological
phenomena
associated
with
gestational
preeclampsia,
preterm
labor.
impact
prenatal
complications
pregnancy-associated
structures,
placenta,
also
be
discussed.
Finally,
draw
conclusions
from
knowledge
provide
future
perspectives
potentially
exploiting
therapeutic
tool
conditions.
Biomedicine & Pharmacotherapy,
Journal Year:
2021,
Volume and Issue:
143, P. 112164 - 112164
Published: Oct. 4, 2021
Resveratrol
(RV)
is
a
well-known
polyphenolic
compound
in
various
plants,
including
grape,
peanut,
and
berry
fruits,
which
quite
famous
for
its
association
with
several
health
benefits
such
as
anti-obesity,
cardioprotective
neuroprotective,
antitumor,
antidiabetic,
antioxidants,
anti-age
effects,
glucose
metabolism.
Significantly,
promising
therapeutic
properties
have
been
reported
cancer,
neurodegeneration,
atherosclerosis
are
regulated
by
synergistic
pathways
that
control
oxidative
stress,
cell
death,
inflammation.
Similarly,
RV
possesses
strong
anti-adipogenic
effect
inhibiting
fat
accumulation
processes
activating
lipolytic
pathways,
exhibiting
their
effects
platelet
aggregation.
The
also
shows
significant
antibacterial
against
food-borne
pathogens
(Listeria,
Campylobacter,
Staphylococcus
aureus,
E.
coli)
an
electron
transport
chain
(ETC)
F0F1-ATPase,
decreases
the
production
of
cellular
energy
leads
to
spread
pathogens.
After
collecting
analyzing
scientific
literature,
it
may
be
concluded
well
tolerated
favorably
affects
cardiovascular,
neurological,
diabetic
disorders.
As
such,
possible
can
considered
best
nutritional
additive
complementary
drug,
especially
candidate.
Therefore,
this
review
would
increase
knowledge
about
blend
inspire
researchers
around
world
consider
pharmaceutical
drug
combat
future
crises
inhumane
diseases.
In
future,
article
will
aware
discoveries
potential
natural
nutraceuticals
drugs
medicine.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(5), P. 1075 - 1075
Published: May 10, 2023
Mitochondria
play
a
major
role
in
ROS
production
and
defense
during
their
life
cycle.
The
transcriptional
activator
PGC-1α
is
key
player
the
homeostasis
of
energy
metabolism
therefore
closely
linked
to
mitochondrial
function.
responds
environmental
intracellular
conditions
regulated
by
SIRT1/3,
TFAM,
AMPK,
which
are
also
important
regulators
biogenesis
In
this
review,
we
highlight
functions
regulatory
mechanisms
within
framework,
with
focus
on
its
involvement
lifecycle
metabolism.
As
an
example,
show
scavenging
under
inflammatory
conditions.
Interestingly,
stress
response
factor
NF-κB,
regulates
immune
response,
reciprocally
regulated.
During
inflammation,
NF-κB
reduces
expression
activity.
Low
activity
leads
downregulation
antioxidant
target
genes
resulting
oxidative
stress.
Additionally,
low
levels
concomitant
promote
activity,
exacerbates
response.
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 25, 2023
Mitochondria
play
a
key
role
in
both
health
and
disease.
Their
function
is
not
limited
to
energy
production
but
serves
multiple
mechanisms
varying
from
iron
calcium
homeostasis
the
of
hormones
neurotransmitters,
such
as
melatonin.
They
enable
influence
communication
at
all
physical
levels
through
interaction
with
other
organelles,
nucleus,
outside
environment.
The
literature
suggests
crosstalk
between
mitochondria
circadian
clocks,
gut
microbiota,
immune
system.
might
even
be
hub
supporting
integrating
activity
across
these
domains.
Hence,
they
(missing)
link
Mitochondrial
dysfunction
related
metabolic
syndrome,
neuronal
diseases,
cancer,
cardiovascular
infectious
inflammatory
disorders.
In
this
regard,
diseases
Alzheimer’s,
Parkinson’s,
amyotrophic
lateral
sclerosis
(ALS),
chronic
fatigue
syndrome
(CFS),
pain
are
discussed.
This
review
focuses
on
understanding
mitochondrial
action
that
allow
for
maintenance
pathways
toward
dysregulated
mechanisms.
Although
have
allowed
us
adapt
changes
over
course
evolution,
turn,
evolution
has
shaped
mitochondria.
Each
evolution-based
intervention
influences
its
own
way.
use
physiological
stress
triggers
tolerance
stressor,
achieving
adaptability
resistance.
describes
strategies
could
recover
functioning
providing
comprehensive,
root-cause-focused,
integrative
approach
recovering
treating
people
suffering
diseases.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 1, 2024
Abstract
Peroxisome
proliferator-activated
receptor
gamma
coactivator-1
(PGC-1)
family
(PGC-1s),
consisting
of
three
members
encompassing
PGC-1α,
PGC-1β,
and
PGC-1-related
coactivator
(PRC),
was
discovered
more
than
a
quarter-century
ago.
PGC-1s
are
essential
coordinators
many
vital
cellular
events,
including
mitochondrial
functions,
oxidative
stress,
endoplasmic
reticulum
homeostasis,
inflammation.
Accumulating
evidence
has
shown
that
implicated
in
diseases,
such
as
cancers,
cardiac
diseases
cardiovascular
neurological
disorders,
kidney
motor
system
metabolic
disorders.
Examining
the
upstream
modulators
co-activated
partners
identifying
critical
biological
events
modulated
by
downstream
effectors
contribute
to
presentation
elaborate
network
PGC-1s.
Furthermore,
discussing
correlation
between
well
summarizing
therapy
targeting
helps
make
individualized
precise
intervention
methods.
In
this
review,
we
summarize
basic
knowledge
regarding
molecular
regulatory
network,
discuss
physio-pathological
roles
human
review
application
PGC-1s,
diagnostic
prognostic
value
several
therapies
pre-clinical
studies,
suggest
directions
for
future
investigations.
This
presents
immense
potential
treatment
hopefully
facilitates
promotion
new
therapeutic
targets.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
13
Published: Feb. 2, 2023
Ischemic
stroke
(IS)
is
one
of
the
most
fatal
diseases.
Neuroimmunity,
inflammation,
and
oxidative
stress
play
important
roles
in
various
complex
mechanisms
IS.
In
particular,
early
proinflammatory
response
resulting
from
overactivation
resident
microglia
infiltration
circulating
monocytes
macrophages
brain
after
cerebral
ischemia
leads
to
secondary
injury.
Microglia
are
innate
immune
cells
that
constantly
monitor
microenvironment
under
normal
conditions.
Once
occurs,
activated
produce
dual
effects
neurotoxicity
neuroprotection,
balance
two
determines
fate
damaged
neurons.
The
activation
defined
as
classical
(M1
type)
or
alternative
(M2
type).
M1
type
secrete
pro-inflammatory
cytokines
neurotoxic
mediators
exacerbate
neuronal
damage,
while
M2
promote
a
repairing
anti-inflammatory
response.
Fine
regulation
M1/M2
microglial
minimize
damage
maximize
protection
has
therapeutic
value.
This
review
focuses
on
interaction
between
other
involved
IS
phenotypic
characteristics,
mechanism
natural
plant
components
regulating
IS,
providing
novel
candidate
drugs
for
drug
development.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 31, 2023
Introduction
Previous
study
has
indicated
Dubosiella
newyorkensis
may
act
as
a
potential
probiotic
in
age-related
diseases.
However,
its
detailed
role
aging
not
yet
been
promulgated.
This
aimed
to
explore
the
anti-aging
of
by
comparing
effect
resveratrol
young
and
old
mice.
Method
Measurement
intestinal
aging-related
factors
colon
serum,
vascular
endothelial
function-related
serum
were
performed
enzyme-linked
immunosorbent
assay
(ELISA).
Gut
microbial
analysis
contents
identified
16S
rRNA
gene
sequencing.
Results
The
on
reducing
malondialdehyde
(MDA)
increasing
superoxide
dismutase
(SOD)
aged
mice
greater
than
that
resveratrol.
While
nitric
oxide
(NO)
level
was
less
resveratrol,
reduction
growth
factor
(VEGF)
pentosidine
(PTD)
better
In
mice,
promoted
an
increase
beneficial
genus
Lactobacillus,
Bifidobacterium
Ileibacterium
effectively
compared
with
treatment.
Bifidobacterium,
Akkermansia,
Staphylococcus,
Verrucomicrobiota
expression
Both
showed
same
results
for
remaining
markers,
including
changes
gut
composition
predictions
function.
Conclusion
similar
functions
even
be
more
effective
oxidative
stress,
improving
function,
redistributing
microbiota.
research
provides
innovative
strategy
improve
aging.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(18)
Published: Jan. 15, 2024
Abstract
Mitochondria,
widely
known
as
the
energy
factories
of
eukaryotic
cells,
have
a
myriad
vital
functions
across
diverse
cellular
processes.
Dysfunctions
within
mitochondria
serve
catalysts
for
various
diseases,
prompting
widespread
demise.
Mounting
research
on
remedying
damaged
indicates
that
constitute
valuable
target
therapeutic
intervention
against
diseases.
But
less
clinical
practice
and
lower
recovery
rate
imply
limitation
traditional
drugs,
which
need
further
breakthrough.
Nanotechnology
has
approached
favorable
regiospecific
biodistribution
high
efficacy
by
capitalizing
excellent
nanomaterials
targeting
drug
delivery.
Mitochondria‐remedying
nanodrugs
achieved
ideal
effects.
This
review
elucidates
significance
in
cells
organs,
while
also
compiling
mortality
data
related
Correspondingly,
nanodrug‐mediate
strategies
applicable
mitochondria‐remedying
disease
are
detailed,
with
full
understanding
roles
dysfunction
advantages
nanodrugs.
In
addition,
future
challenges
directions
discussed.
conclusion,
this
provides
comprehensive
insights
into
design
development
nanodrugs,
aiming
to
help
scientists
who
desire
extend
their
fields
engage
interdisciplinary
subject.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1098 - 1098
Published: Jan. 27, 2025
This
article
reviews
the
synergistic
effects
of
antioxidant-enriched
functional
foods
and
exercise
in
improving
metabolic
health,
focusing
on
underlying
molecular
mechanisms.
The
review
incorporates
evidence
from
PubMed,
SCOPUS,
Web
Science,
PsycINFO,
reference
lists
relevant
up
to
20
December
2024,
highlighting
central
role
Nrf2
pathway.
As
a
critical
regulator
oxidative
stress
adaptation,
mediates
benefits
these
interventions.
presents
an
innovative
approach
understanding
regulation
inflammation,
its
potential
prevention
treatment
various
diseases,
including
cancer,
neurodegenerative
disorders,
cardiovascular
pulmonary
diabetes,
inflammatory
conditions,
ageing,
infections
such
as
COVID-19.
novelty
this
study
is
investigate
bioactive
compounds
found
(such
polyphenols,
flavonoids,
vitamins)
exercise-induced
activation
combined
reveals
their
improve
insulin
sensitivity
lipid
metabolism
reduce
offering
promising
strategy
for
management
chronic
diseases.
However,
there
are
significant
gaps
current
research,
particularly
regarding
mechanisms
interaction
between
diet,
physical
activity,
activation,
well
long-term
different
populations,
those
with
In
addition,
interactions
other
signalling
pathways,
AMPK,
NF-κB,
PI3K/Akt,
collective
contributions
health
explored.
Furthermore,
novel
biomarkers
presented
assess
impact
strategies,
NAD+/NADH
ratio,
GSH
markers
mitochondrial
health.
findings
provide
valuable
insights
into
how
integration
antioxidant-rich
diet
regular
can
by
activating
related
pathways
represent
strategies
disorders.
Further
studies
needed
fully
understand
therapeutic
interventions
diseases
stress,
disease,
cancer.
