Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1845 - 1845

Published: Feb. 15, 2023

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical medicinal sections to promote human health prevent cure different diseases. The most common found nature anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, other sub-classes. impacts of plant phenolics on promoting diseases curing preventing antioxidant effects, antibacterial impacts, cardioprotective anticancer immune system promoting, anti-inflammatory skin protective effects from UV radiation. This work aims provide an overview phenolic as important sources medical application according recently published studies, well some interesting directions future research. keyword searches flavonoids, phenolics, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, secoiridoids were performed by using Web Science, Scopus, Google scholar, PubMed. acids contain a carboxylic acid group addition the basic structure mainly divided into hydroxybenzoic hydroxycinnamic acids. Hydroxybenzoic based C6-C1 skeleton often bound small organic acids, glycosyl moieties, or cell structural components. Common include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, salicylic Hydroxycinnamic C6-C3 also molecules such quinic glucose. main caffeic, p-coumaric, ferulic, sinapic

Language: Английский

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AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 146, P. 112563 - 112563

Published: Dec. 29, 2021

Diabetes mellitus (DM) is considered as a main challenge in both developing and developed countries, lifestyle has changed its management seems to be vital. Type I type II diabetes are the kinds they result hyperglycemia patients related complications. The gene expression alteration can lead development of DM AMP-activated protein kinase (AMPK) an energy sensor with aberrant various diseases including cancer, cardiovascular DM. present review focuses on understanding AMPK role Inducing signaling promotes glucose that importance for ameliorating hyperglycemia. Further investigation reveals enhancing insulin sensitivity treatment diabetic patients. Furthermore, upregulation inhibits stress cell death β cells preventing development. clinical studies have shown improving complications such brain disorders. improve neuropathy, nephropathy, liver reproductive alterations occurring during For exerting protective impacts, interacts other molecular pathways PGC-1α, PI3K/Akt, NOX4 NF-κB among others. Therefore, providing therapeutics based targeting beneficial amelioration

Language: Английский

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Autophagy and cancer drug resistance in dialogue: Pre-clinical and clinical evidence

Cancer Letters, Journal Year: 2023, Volume and Issue: 570, P. 216307 - 216307

Published: July 12, 2023

Language: Английский

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NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(7), P. 2770 - 2795

Published: May 13, 2022

Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival prognosis cancer patients. The epithelial-to-mesenchymal transition (EMT) well-known mechanism responsible for invasiveness cells. A number molecular pathways can regulate EMT in nuclear factor-kappaB (NF-κB) one them. translocation NF-κB p65 induce transcription several genes involved induction. present review describes interaction their association progression. Due to oncogenic role signaling, its activation enhances metastasis via This has been confirmed various cancers including brain, breast, lung gastric cancers, among others. ZEB1/2, transforming growth factor-β, Slug as inducers undergo upregulation by promote After induction driven NF-κB, significant decrease occurs E-cadherin levels, while N-cadherin vimentin levels an increase. noncoding RNAs potentially also function upstream mediators modulate NF-κB/EMT axis cancers. Moreover, mediating drug resistance Thus, suppressing sensitivity chemotherapeutic agents.

Language: Английский

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Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 10, 2022

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA its derivatives have been used for many centuries due to their natural healing medicinal properties. possesses various biological pharmacological activities, including antioxidant, anti-inflammatory, anticancer, neuroprotective effects. The potential therapeutic effects of are mediated via repression inhibition transcription growth factors. anticancer human cell cultures animal models. However, the biomolecular interactions pathways described highlighting target binding proteins signaling molecules. current review focuses on CA’s chemical, physical, properties, We further characteristics future directions.

Language: Английский

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Caffeic Acid and Diseases—Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 588 - 588

Published: Dec. 29, 2022

Caffeic acid belongs to the polyphenol compounds we consume daily, often in form of coffee. Even though it is less explored than caffeic phenethyl ester, still has many positive effects on human health. can affect cancer, diabetes, atherosclerosis, Alzheimer’s disease, or bacterial and viral infections. This review focuses molecular mechanisms how achieves its effects.

Language: Английский

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Chlorogenic acid for cancer prevention and therapy: Current status on efficacy and mechanisms of action

Pharmacological Research, Journal Year: 2022, Volume and Issue: 186, P. 106505 - 106505

Published: Oct. 13, 2022

Language: Английский

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(Nano)platforms in bladder cancer therapy: Challenges and opportunities

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 8, 2022

Urological cancers are among the most common malignancies around world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for treatment of although prognosis remains unfavorable. It is perceived that depends on an interdisciplinary approach combining biology engineering. The nanotechnological approaches introduced in various cancers, especially cancer. current review aims emphasize highlight possible applications nanomedicine eradication tumor. Nanoparticles can improve efficacy drugs therapy through elevating their bioavailability. potential genetic tools such as siRNA miRNA gene expression regulation be boosted using nanostructures by facilitating internalization accumulation at tumor sites cells. provide photodynamic photothermal ROS overgeneration hyperthermia, respectively, suppression Furthermore, remodeling microenvironment infiltration immune cells purpose immunotherapy achieved cargo-loaded nanocarriers. Nanocarriers mainly internalized endocytosis, proper design smart nanoparticles pH-, redox-, light-responsive nanocarriers importance targeted therapy. Bladder biomarkers detected timely diagnosis patients. Based site, they employed imaging. clinical translation challenges also covered review.

Language: Английский

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Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106553 - 106553

Published: Nov. 16, 2022

Cancer progression results from activation of various signaling networks. Among these, PI3K/Akt contributes to proliferation, invasion, and inhibition apoptosis. Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence rate, especially in regions prevalence viral hepatitis infection. Autoimmune disorders, diabetes mellitus, obesity, alcohol consumption, inflammation can also lead initiation development HCC. The treatment HCC depends on the identification oncogenic factors that tumor cells develop resistance therapy. present review article focuses role progression. Activation promotes glucose uptake, favors glycolysis increases cell proliferation. It inhibits both apoptosis autophagy while promoting survival. stimulates epithelial-to-mesenchymal transition (EMT) matrix-metalloproteinase (MMP) expression during metastasis. In addition increasing colony formation capacity facilitating spread cells, angiogenesis. Therefore, silencing prevents aggressive behavior. confer drug resistance, particularly sorafenib, decreases radio-sensitivity cells. Anti-cancer agents, like phytochemicals small molecules suppress by limiting Being upregulated tissues clinical samples, be used as biomarker predict patients' response

Language: Английский

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Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer

Antioxidants, Journal Year: 2023, Volume and Issue: 12(1), P. 127 - 127

Published: Jan. 5, 2023

Polyphenols are a broad group of bioactive phytochemicals with powerful antioxidant, anti-inflammatory, immunomodulatory, and antiviral activities. Numerous studies have demonstrated that polyphenol extracts obtained from natural sources can be used for the prevention treatment cancer. Pomegranate peel extract is an excellent source polyphenols, such as punicalagin, punicalin, ellagic acid, caffeic among others. These phenolic compounds antineoplastic activity in vitro models cervical cancer through regulation cellular redox balance, induction apoptosis, cell cycle arrest, modulation different signaling pathways. The current review summarizes recent data scientific reports address anticancer predominant present PPE their mechanisms action models.

Language: Английский

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