Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 12, 2023
Bryophyllumpinnatum
(Crassulaceae)
is
used
in
traditional
medicine
for
treating
skin
wounds.
In
our
previous
study,
a
topical
gel
containing
B.
pinnatum
aqueous
leaf
extract
showed
preclinical
anti-inflammatory
effect
vivo
acute
edema
models.
continuation,
the
present
study
aims
to
evaluate
phytochemical
content
and
stability
of
formulation
its
healing
properties
mechanism
action
through
an
experimental
model
induction
wounds
rats
vitro
assays.
The
animals
were
treated
topically
7
or
14
days
with
at
5%
placebo
Fibrinase®
cream.
addition,
establish
some
quality
control
parameters,
total
phenolic
(TPC),
flavonoid
(TFC),
focusing
on
biological
30
two
different
conditions
(room
temperature
40°C/75%
RH)
performed.
Gel
TPC
TFC
2.77
±
0.06
mg
gallic
acid/g
1.58
0.03
quercetin/g,
respectively.
Regarding
no
significant
change
following
parameters:
pH,
water
activity,
chromatographic
profile,
major
compound
identified
extract.
stimulated
wound
while
reducing
area,
as
well
decreasing
inflammatory
infiltrate,
levels
IL-1β
TNF-α,
stimulating
angiogenesis
increased
expression
VEGF,
similar
Fibrinase.
conclusion,
exhibited
relevant
and,
therefore,
has
potential
be
applied
novel
active
ingredient
developing
pharmaceuticals.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(4), P. 1845 - 1845
Published: Feb. 15, 2023
Phenolic
compounds
and
flavonoids
are
potential
substitutes
for
bioactive
agents
in
pharmaceutical
medicinal
sections
to
promote
human
health
prevent
cure
different
diseases.
The
most
common
found
nature
anthocyanins,
flavones,
flavanones,
flavonols,
flavanonols,
isoflavones,
other
sub-classes.
impacts
of
plant
phenolics
on
promoting
diseases
curing
preventing
antioxidant
effects,
antibacterial
impacts,
cardioprotective
anticancer
immune
system
promoting,
anti-inflammatory
skin
protective
effects
from
UV
radiation.
This
work
aims
provide
an
overview
phenolic
as
important
sources
medical
application
according
recently
published
studies,
well
some
interesting
directions
future
research.
keyword
searches
flavonoids,
phenolics,
tannins,
coumarins,
lignans,
quinones,
xanthones,
curcuminoids,
stilbenes,
cucurmin,
phenylethanoids,
secoiridoids
were
performed
by
using
Web
Science,
Scopus,
Google
scholar,
PubMed.
acids
contain
a
carboxylic
acid
group
addition
the
basic
structure
mainly
divided
into
hydroxybenzoic
hydroxycinnamic
acids.
Hydroxybenzoic
based
C6-C1
skeleton
often
bound
small
organic
acids,
glycosyl
moieties,
or
cell
structural
components.
Common
include
gallic,
syringic,
protocatechuic,
p-hydroxybenzoic,
vanillic,
gentistic,
salicylic
Hydroxycinnamic
C6-C3
also
molecules
such
quinic
glucose.
main
caffeic,
p-coumaric,
ferulic,
sinapic
Food Science & Nutrition,
Journal Year:
2023,
Volume and Issue:
11(6), P. 2500 - 2529
Published: April 17, 2023
Phytobioactive
compounds
are
plant
secondary
metabolites
and
bioactive
abundantly
present
in
medicinal
plants
have
remarkable
therapeutic
potential.
Oxidative
stress
antibiotic
resistance
major
causes
of
present-day
ailments
such
as
diabetes,
atherosclerosis,
cardiovascular
disorders,
cancer,
inflammation.
The
data
for
this
review
were
collected
from
Google
Scholar,
PubMed,
Directory
Open
Access
Journals
(DOAJ),
Science
Direct
by
using
keywords:
"Medicinal
plants,
compounds,
Polyphenols,
Alkaloids,
Carotenoids
etc."
Several
studies
reported
the
pharmacological
potential
phytobioactives.
alkaloids,
terpenes,
polysaccharides
isolated
showed
antioxidant,
anticancer,
cytotoxic,
anti-inflammatory,
cardioprotective,
hepatoprotective,
immunomodulatory,
neuroprotective,
antidiabetic
activities.
This
literature
was
planned
to
provide
comprehensive
insight
into
biopharmacological
phytobioactive
compounds.
techniques
used
extraction
isolation
bioassays
required
their
biological
activities
antimicrobial,
cytotoxic
activities,
been
discussed.
Characterization
structural
elucidation
HPLC,
TLC,
FTIR,
GC-MS/MS,
NMR
also
concludes
that
may
be
alternative
synthetic
agents
treatment
various
diseases.
ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(35), P. 30657 - 30672
Published: Aug. 24, 2022
Reactive
oxygen
species
(ROS)
is
considered
a
double-edged
sword.
The
slightly
elevated
level
of
ROS
helps
in
wound
healing
by
inhibiting
microbial
infection.
In
contrast,
excessive
levels
the
site
show
deleterious
effects
on
extending
inflammation
phase.
Understanding
ROS-mediated
molecular
and
biomolecular
mechanisms
their
effect
cellular
homeostasis
thus
substantially
improves
possibility
exogenously
augmenting
manipulating
with
emerging
antioxidant
therapeutics.
This
review
comprehensively
delves
into
relationship
between
critical
phases
processes
underpinning
therapies.
manuscript
also
discusses
cutting-edge
therapeutics
that
act
via
scavenging
to
enhance
chronic
healing.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(16), P. 3266 - 3266
Published: Aug. 11, 2022
Bleeding
control
plays
a
very
important
role
in
worldwide
healthcare,
which
also
promotes
research
and
development
of
wound
dressings.
The
healing
process
involves
four
stages
hemostasis,
inflammation,
proliferation
remodeling,
is
complex
process,
dressings
play
huge
it.
Electrospinning
technology
simple
to
operate.
Electrospun
nanofibers
have
high
specific
surface
area,
porosity,
oxygen
permeability,
excellent
mechanical
properties,
show
great
utilization
value
the
manufacture
As
one
most
popular
reactive
functional
synthetic
polymers,
polyacrylonitrile
(PAN)
frequently
explored
create
for
wide
variety
applications.
In
recent
years,
researchers
invested
application
PAN
Research
on
spun
reviewed,
future
directions
prospects
electrospun
are
proposed.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(5), P. 2298 - 2316
Published: Jan. 26, 2024
Bacterial
infection
hampers
wound
repair
by
impeding
the
healing
process.
Concurrently,
inflammation
at
site
triggers
production
of
reactive
oxygen
species
(ROS),
causing
oxidative
stress
and
damage
to
proteins
cells.
This
can
lead
chronic
wounds,
posing
severe
risks.
Therefore,
eliminating
bacterial
reducing
ROS
levels
are
crucial
for
effective
healing.
Nanozymes,
possessing
enzyme-like
catalytic
activity,
convert
endogenous
substances
into
highly
toxic
substances,
such
as
ROS,
combat
bacteria
biofilms
without
inducing
drug
resistance.
However,
current
nanozyme
model
with
single
enzyme
activity
falls
short
meeting
complex
requirements
antimicrobial
therapy.
Thus,
developing
nanozymes
multiple
enzymatic
activities
is
essential.
Herein,
we
engineered
a
novel
metalloenzyme
called
Ru-procyanidin
nanoparticles
(Ru-PC
NPs)
diverse
aid
infections.
Under
acidic
conditions,
due
their
glutathione
(GSH)
depletion
peroxidase
(POD)-like
Ru-PC
NPs
combined
H2O2
exhibit
excellent
antibacterial
effects.
in
neutral
environment,
NPs,
catalase
(CAT)
decompose
O2,
alleviating
hypoxia
ensuring
sufficient
supply.
Furthermore,
possess
exceptional
antioxidant
capacity
through
superior
superoxide
dismutase
(SOD)
effectively
scavenging
excess
nitrogen
(RNS)
environment.
maintains
balance
system
prevents
inflammation.
also
promote
polarization
macrophages
from
M1
M2,
facilitating
More
importantly,
show
good
biosafety
negligible
toxicity.
In
vivo
models
have
confirmed
efficacy
inhibiting
promoting
The
focus
this
work
highlights
quadruple
its
potential
reduce
bacteria-infected
