Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment

Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(10), P. 836 - 849

Published: July 22, 2022

Language: Английский

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ER stress and inflammation crosstalk in obesity

Medicinal Research Reviews, Journal Year: 2022, Volume and Issue: 43(1), P. 5 - 30

Published: Aug. 17, 2022

Abstract The endoplasmic reticulum (ER) governs the proper folding of polypeptides and proteins through various chaperones enzymes residing within ER organelle. Perturbation in process ensues when overwhelmed protein exceeds handling capacity, leading to accumulation misfolded/unfolded lumen—a state being referred as stress. In turn, stress induces a gamut signaling cascades, termed “unfolded response” (UPR) that reinstates homeostasis panel gene expression modulation. This type UPR is usually deemed “adaptive UPR.” However, persistent or unresolved hyperactivates response, which ultimately, triggers cell death inflammatory pathways, “maladaptive/terminal A plethora evidence indicates crosstalks between (maladaptive UPR) inflammation precipitate obesity pathogenesis. this regard, acquisition mechanisms linking might unveil potential remedies tackle pathological condition. Herein, we aim elucidate key stress‐induced context summarize therapeutic strategies management maneuvering stress‐associated inflammation.

Language: Английский

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Melatonin: Facts, Extrapolations and Clinical Trials

Biomolecules, Journal Year: 2023, Volume and Issue: 13(6), P. 943 - 943

Published: June 5, 2023

Melatonin is a fascinating molecule that has captured the imagination of many scientists since its discovery in 1958. In recent times, focus changed from investigating natural role as transducer biological time for physiological systems to hypothesized roles virtually all clinical conditions. This goes along with appearance extensive literature claiming (generally) positive benefits high doses melatonin animal models and various situations would not be receptor-mediated. Based on assumption safe, have been administered patients, including elderly children, trials. this review, we critically review corresponding literature, hypotheses acts scavenger molecule, particular mitochondria, by trying only contextualize these interests but also attempting separate wheat chaff (or wishful thinking facts). We conclude most claims remain experimental evidence used promote them limited sometimes flawed. Our will hopefully encourage researchers reflect what can cannot do help move field forward solid basis.

Language: Английский

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Mitophagy in atherosclerosis: from mechanism to therapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 16, 2023

Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity cellular homeostasis. Several pathways have been found participate in different steps mitophagy. plays significant role the homeostasis physiological function vascular endothelial cells, smooth muscle macrophages, involved development atherosclerosis (AS). At present, many medications natural chemicals shown alter mitophagy slow progression AS. This review serves as an introduction field for researchers interested targeting this pathway part potential AS management strategy.

Language: Английский

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Inflammaging: mechanisms and role in the cardiac and vasculature

Trends in Endocrinology and Metabolism, Journal Year: 2023, Volume and Issue: 34(6), P. 373 - 387

Published: April 17, 2023

Language: Английский

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Melatonin Treatment in Kidney Diseases

Cells, Journal Year: 2023, Volume and Issue: 12(6), P. 838 - 838

Published: March 8, 2023

Melatonin is a neurohormone that mainly secreted by the pineal gland. It coordinates work of superior biological clock and consequently affects many processes in human body. Disorders waking sleeping period result nervous system imbalance generate metabolic endocrine derangements. The purpose this review to provide information regarding potential benefits melatonin use, particularly kidney diseases. impact on cardiovascular system, diabetes, homeostasis causes be indirectly connected function quality life people with chronic disease. Moreover, there are numerous reports showing plays role as an antioxidant, free radical scavenger, cytoprotective agent. This means supplementation can helpful almost every type injury because inflammation, apoptosis, oxidative stress occur, regardless mechanism. administration has renoprotective effect inhibits progression complications renal failure. very important exogenous well tolerated number side effects caused treatment low.

Language: Английский

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Effects of mitochondrial dysfunction on cellular function: Role in atherosclerosis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116587 - 116587

Published: April 17, 2024

Atherosclerosis, an immunoinflammatory disease of medium and large arteries, is associated with life-threatening clinical events, such as acute coronary syndromes stroke. Chronic inflammation impaired lipoprotein metabolism are considered to be among the leading causes atherosclerosis, while numerous risk factors, including arterial hypertension, diabetes mellitus, obesity, aging, can contribute development disease. In recent years, emerging evidence has underlined key role mitochondrial dysfunction in pathogenesis atherosclerosis. Mitochondrial believed result increase reactive oxygen species, oxidative stress, chronic inflammation, intracellular lipid deposition, all which Critical cells, endothelial vascular smooth muscle macrophages, play important function also involved maintaining normal these cells. To better understand relationship between this review summarizes findings studies discusses factors critical cells Two processes a decisive atherosclerosis: major unifying mechanism several atherosclerosis Therapies targeting promising strategies treat How does excessive species production affect atherosclerosis? do disorders function?

Language: Английский

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Targeted delivery of rosuvastatin enhances treatment of HHcy-induced atherosclerosis using macrophage membrane-coated nanoparticles

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 14(9), P. 100937 - 100937

Published: Jan. 20, 2024

Rosuvastatin (RVS) is an excellent drug with anti-inflammatory and lipid-lowering properties in the academic medical fields. However, this faces a series of challenges when used to treat atherosclerosis caused by hyperhomocysteinemia (HHcy), including high oral dosage, poor targeting, long-term toxic side effects. In study, we applied nanotechnology construct biomimetic nano-delivery system, macrophage membrane (Møm)-coated RVS-loaded Prussian blue (PB) nanoparticles (MPR NPs), for improving bioavailability targeting capacity RVS, specifically plaque lesions associated HHcy-induced atherosclerosis.

Language: Английский

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Epigenetic modification in alcohol‐related liver diseases

Medicinal Research Reviews, Journal Year: 2022, Volume and Issue: 42(4), P. 1463 - 1491

Published: Feb. 21, 2022

Abstract Alcohol‐related liver disease (ARLD) refers to a spectrum of hepatic damage triggered by excessive alcohol intake, resulting in inflamed and swollen livers, ultimately, cirrhosis. Alcoholic (ALD) is similar term denoting disorders encompassing steatosis, cirrhosis, hepatocellular carcinoma. Recent evidence has suggested vital role for epigenetic factors, which modulate gene expression the absence changes DNA sequence, onset progression disorders, foster fibrogenesis Mounting findings have delineated that consumption extensively modulates epigenetics, thus, prompting etiology ARLD ALD. Alcohol‐induced modifications (AIEM) encompass histone modification, microRNA‐induced genetic modulation, methylation, alcohol‐evoked cell signaling alters expression. Herein, we aim at summarizing key decipher AIEM its development ALD from perspectives both cellular animal models exposure. Furthermore, will share our viewpoints on epigenetics‐based therapeutic options management

Language: Английский

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Nanoparticles in the New Era of Cardiovascular Therapeutics: Challenges and Opportunities

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5205 - 5205

Published: March 8, 2023

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Although a cadre therapeutic strategies have been made available for CVDs in clinical setting, predominantly through medication surgery, these do not fully address needs patients with CVD. As new technique CVD treatment, nanocarriers are employed to modify package medications ease targeting tissues, cells molecules within cardiovascular system. Nanocarriers biomaterials, metals, or combination materials, sizes similar bioactive such as proteins DNA. nanomedicine (CVN) has only surfaced recent years still its infancy. Ample studies displayed promise utility techniques, courtesy continued perfection nanocarrier design optimize drug delivery treatment outcomes. Here this review, we will summarize research advances literature on nanoparticles management CVDs, including ischemic coronary heart (e.g., atherosclerosis, angina pectoris myocardial infarction), ischemia-reperfusion injury, aortic aneurysm, myocarditis, hypertension, pulmonary artery hypertension thrombosis.

Language: Английский

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