Flavonoids: an overview

Journal of Nutritional Science, Journal Year: 2016, Volume and Issue: 5

Published: Jan. 1, 2016

Abstract Flavonoids, a group of natural substances with variable phenolic structures, are found in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. These products well known for their beneficial effects on health efforts being made to isolate the ingredients so called flavonoids. Flavonoids now considered as an indispensable component variety nutraceutical, pharmaceutical, medicinal cosmetic applications. This is attributed anti-oxidative, anti-inflammatory, anti-mutagenic anti-carcinogenic properties coupled capacity modulate key cellular enzyme function. Research flavonoids received added impulse discovery low cardiovascular mortality rate also prevention CHD. Information working mechanisms still not understood properly. However, it has widely been centuries that derivatives plant origin possess broad spectrum biological activity. Current trends research development activities relate isolation, identification, characterisation functions finally applications benefits. Molecular docking knowledge bioinformatics used predict potential manufacturing by industry. In present review, attempts have discuss current flavonoids, flavonoid applications, prediction drugs preventing chronic diseases future directions.

Language: Английский

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Polyphenols: A concise overview on the chemistry, occurrence, and human health

Phytotherapy Research, Journal Year: 2019, Volume and Issue: 33(9), P. 2221 - 2243

Published: July 29, 2019

This review gives an updated picture of each class phenolic compounds and their properties. The most common classification implies the subdivision phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, isoflavones) non‐flavonoids acids, xanthones, stilbens, lignans, tannins) polyphenols. great interest polyphenols is associated with high potential application for food preservation therapeutic beneficial use. relationship between polyphenol intake human health has been exploited special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, cancer. use current existing databases bioactive including described as key tools research.

Language: Английский

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Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects

Molecules, Journal Year: 2021, Volume and Issue: 27(1), P. 233 - 233

Published: Dec. 30, 2021

Inflammation is a natural protective mechanism that occurs when the body’s tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent diseases. Some phenolic compounds work in tandem with nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit mediators’ activity gene expression, including cyclooxygenase (COX). Various can also act on transcription factors, nuclear factor-κB (NF-κB) factor-erythroid factor 2-related 2 (Nrf-2), up-or downregulate elements within antioxidant pathways. Phenolic enzymes associated development of human diseases and have been used treat various common ailments, hypertension, metabolic problems, incendiary infections, neurodegenerative inhibition angiotensin-converting enzyme (ACE) has hypertension. carbohydrate hydrolyzing represents type diabetes mellitus therapy, cholinesterase applied Alzheimer’s disease (AD). demonstrated properties skin diseases, rheumatoid arthritis, inflammatory bowel disease. Plant extracts exert effects against oxidative stress inflammation caused airborne particulate matter, addition range anti-inflammatory, anticancer, anti-aging, antibacterial, antiviral activities. Dietary polyphenols prevent allergy-related biological contributions cardiovascular described. This review summarizes recent progress delineating multifunctional roles compounds, their molecular pathways through which they disorders. study discusses current issues potential prospects for therapeutic application

Language: Английский

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The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2018, Volume and Issue: 17(5), P. 1054 - 1112

Published: July 10, 2018

Abstract Flavonoids are plant‐derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and complex pathways involved bioavailability of flavonoids body now well understood. In recent years, been appreciated that gut microbiome plays major role flavonoid action, but much progress still needs to be made this area. Since first publications health effects flavonoids, their action is understood protect against various stresses, mechanism evolved from debunked simple direct antioxidant hypothesis into an understanding molecular targets enzymes specific cell types. This review traces development field over past 8 decades, indicates current state art, how was reached. Future recommendations based historical analysis (a) focus key areas (b) perform intervention studies focusing protective effects, (c) carry out cellular vitro experiments using appropriate cells together chemical form found at site action; could native compounds food for digestion intestine, conjugated metabolites blood after absorption small intestine cells, or forms tissues catabolism by microbiota.

Language: Английский

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Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Pharmacological Research, Journal Year: 2020, Volume and Issue: 163, P. 105224 - 105224

Published: Sept. 29, 2020

Language: Английский

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Beyond the Cholesterol-Lowering Effect of Soy Protein: A Review of the Effects of Dietary Soy and Its Constituents on Risk Factors for Cardiovascular Disease

Nutrients, Journal Year: 2017, Volume and Issue: 9(4), P. 324 - 324

Published: March 24, 2017

The hypocholesterolemic effect of soy is well-documented and this has led to the regulatory approval a health claim relating protein reduced risk cardiovascular disease (CVD). However, soybeans contain additional components, such as isoflavones, lecithins, saponins fiber that may improve through independent mechanisms. This review summarizes evidence on benefits non-protein components in relation known CVD factors hypertension, hyperglycemia, inflammation, obesity beyond cholesterol lowering. Overall, available suggests constituents markers health; however, carefully designed studies are required independently elucidate these effects. Further, work also needed clarify role isoflavone-metabolizing phenotype gut microbiota composition biological effect.

Language: Английский

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Current evidence on the effect of dietary polyphenols intake on chronic diseases

Food and Chemical Toxicology, Journal Year: 2017, Volume and Issue: 110, P. 286 - 299

Published: Oct. 15, 2017

Language: Английский

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Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Plants, Journal Year: 2023, Volume and Issue: 12(6), P. 1217 - 1217

Published: March 7, 2023

Polyphenol has been used in treatment for some health disorders due to their diverse promoting properties. These compounds can reduce the impacts of oxidation on human body, prevent organs and cell structure against deterioration protect functional integrity. The abilities are attributed high bioactivity imparting them antioxidative, antihypertensive, immunomodulatory, antimicrobial, antiviral activity, as well anticancer application polyphenols such flavonoids, catechin, tannins, phenolic acids food industry bio-preservative substances foods beverages exert a superb activity inhibition oxidative stress via different types mechanisms. In this review, detailed classification polyphenolic compunds important with special focus addressed. Additionally, ability inhibit SARS-CoV-2 could be alternative therapy treat COVID patients. Inclusions various have demonstrated extend shelf life they positive (antioxidative, anticancer). virus reported. Considering natural occurrence GRAS status highly recommended food.

Language: Английский

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Food flavonols: Nutraceuticals with complex health benefits and functionalities

Trends in Food Science & Technology, Journal Year: 2021, Volume and Issue: 117, P. 194 - 204

Published: March 26, 2021

Language: Английский

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An ethnopharmacological review on the therapeutical properties of flavonoids and their mechanisms of actions: A comprehensive review based on up to date knowledge

Toxicology Reports, Journal Year: 2022, Volume and Issue: 9, P. 445 - 469

Published: Jan. 1, 2022

Flavonoids -a class of low molecular weight secondary metabolites- are ubiquitous and cornucopia throughout the plant kingdom. Structurally, main structure consists C6-C3-C6 rings with different substitution patterns so that many sub-classes obtained, for example: flavonols, flavonolignans, flavonoid glycosides, flavans, anthocyanidins, aurones, flavones, neoflavonoids, chalcones, isoflavones, flavones flavanones. evaluated to have drug like nature since they possess therapeutic activities, can act as cardioprotective, antiviral, antidiabetic, anti-inflammatory, antibacterial, anticancer, also work against Alzheimer's disease others. However, information on relationship between their biological activity is scarce. Therefore, present review tries summarize all activities flavonoids, mechanisms action relationship.

Language: Английский

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