The American Journal of Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 36
Published: Sept. 30, 2024
Liver
fibrosis
is
a
common
complication
of
chronic
liver
disease,
significantly
affecting
patients’
quality
life
and
potentially
leading
to
cirrhosis
hepatocellular
carcinoma.
Despite
advancements
in
modern
medicine,
the
treatment
remains
limited
challenging.
Thus,
identifying
new
therapeutic
strategies
great
clinical
importance.
Signaling
pathways
related
play
crucial
regulatory
role
immune
response
inflammation.
Aberrant
activation
specific
pathways,
such
as
NF-[Formula:
see
text]B
signaling
pathway,
results
overexpression
genes
associated
with
inflammation
fibrosis,
thereby
promoting
progression
fibrosis.
Chinese
medicine
offers
unique
potential
advantages
approach.
Recent
studies
have
increasingly
demonstrated
that
certain
medicines
can
effectively
treat
by
regulating
relevant
pathways.
The
active
ingredients
these
inhibit
hepatic
inflammatory
responses
fibrotic
processes
interfering
thus
reducing
severity
This
paper
aims
investigate
mechanisms
treating
its
modulation
Additionally,
it
discusses
prospects
application
treatments
provides
valuable
references
for
further
research
practice.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(1), P. 236 - 236
Published: Jan. 1, 2024
Salvianolic
acid
B
(Sal
B)
is
the
primary
water-soluble
bioactive
constituent
derived
from
roots
of
Salvia
miltiorrhiza
Bunge.
This
research
was
designed
to
reveal
potential
mechanism
Sal
anti-liver
injury
perspective
macrophages.
In
our
lipopolysaccharide-induced
M1
macrophage
model,
showed
a
clear
dose-dependent
gradient
inhibition
trend
type.
Moreover,
downregulated
expression
lactate
dehydrogenase
A
(LDHA),
while
overexpression
LDHA
impaired
B’s
effect
inhibiting
polarization.
Additionally,
this
study
revealed
that
exhibited
inhibitory
effects
on
lactylation
process
histone
H3
lysine
18
(H3K18la).
ChIP-qPCR
analysis,
observed
drive
reduction
in
H3K18la
levels
promoter
region
LDHA,
NLRP3,
and
IL-1β
genes.
Furthermore,
vivo
experiments
has
good
alleviating
CCl4-induced
liver
injury.
An
examination
tissues
Kupffer
cells
isolated
those
proved
affects
polarization
macrophages
level
lactylation.
Together,
data
by
downregulating
treatment
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
190, P. 106737 - 106737
Published: March 20, 2023
Nucleotide
analogs
treatment
can
reverse
liver
fibrosis
in
chronic
hepatitis
B
(CHB).
However,
it
has
limited
effect
on
resolution
patients
with
CHB,
particularly
preventing
progression
to
hepatocellular
carcinoma
(HCC).
Ruangan
granule
(RG),
a
Chinese
herbal
formula,
proven
produce
therapeutic
against
animal
experiment.
Thus,
we
aimed
evaluate
the
of
our
formula
(RG)
combined
entecavir
(ETV)
advanced
fibrosis/early
cirrhosis
from
CHB.
A
total
240
CHB
histologically
confirmed
12
centers
were
randomly
and
blindly
allocated
consume
either
ETV
(0.5
mg/day)
plus
RG
(2
times/day)
or
control
for
48
weeks
(wk)
treatment.
Changes
histopathology,
serology
imageology
observed.
Liver
reversion,
defined
as
reduction
Knodell
HAI
score
by
≥
2
points
Ishak
1
grade,
was
assessed.
The
rate
regression
inflammation
remission
after
wk
histopathology
significantly
higher
+
group
(38.73%
vs.
23.94%,
P
=
0.031).
ultrasonic
semiquantitative
scores
decreased
41
(28.87%)
15
(21.13%)
ETV+RG
groups,
respectively
(P
0.026).
had
lower
Fibrosis-4
(FIB-4)
index
0.028).
There
significant
difference
between
groups
function
normalization
<
0.01).
Moreover,
combination
further
reduced
risk
HCC
median
55-month
follow-up
This
study
illustrates
that
improve
reducing
HCC.
World Journal of Gastroenterology,
Journal Year:
2023,
Volume and Issue:
29(9), P. 1446 - 1459
Published: March 7, 2023
Liver
fibrosis
is
a
wound-healing
response
following
chronic
liver
injury
caused
by
hepatitis
virus
infection,
obesity,
or
excessive
alcohol.
It
dynamic
and
reversible
process
characterized
the
activation
of
hepatic
stellate
cells
excess
accumulation
extracellular
matrix.
Advanced
could
lead
to
cirrhosis
even
cancer,
which
has
become
significant
health
burden
worldwide.
Many
studies
have
revealed
that
noncoding
RNAs
(ncRNAs),
including
microRNAs,
long
circular
RNAs,
are
involved
in
pathogenesis
development
regulating
signaling
pathways
transforming
growth
factor-β
pathway,
phosphatidylinositol
3-kinase/protein
kinase
B
Wnt/β-catenin
pathway.
NcRNAs
serum
exosomes
been
reported
tentatively
applied
diagnosis
staging
combined
with
elastography
improve
accuracy
diagnosis.
mimics,
ncRNAs
mesenchymal
stem
cell-derived
exosomes,
lipid
nanoparticles-encapsulated
promising
therapeutic
approaches
for
treatment
fibrosis.
In
this
review,
we
update
latest
knowledge
on
progression
fibrosis,
discuss
potentials
challenges
use
these
diagnosis,
All
will
help
us
develop
comprehensive
understanding
role
