动物学研究,
Journal Year:
2023,
Volume and Issue:
44(6), P. 1132 - 1145
Published: Jan. 1, 2023
Alzheimer's
disease
(AD)
is
an
age-related
progressive
neurodegenerative
disorder
that
leads
to
cognitive
impairment
and
memory
loss.
Emerging
evidence
suggests
autophagy
plays
important
role
in
the
pathogenesis
of
AD
through
regulation
amyloid-beta
(Aβ)
tau
metabolism,
dysfunction
exacerbates
amyloidosis
pathology.
Therefore,
targeting
may
be
effective
approach
for
treatment
AD.
Animal
models
are
considered
useful
tools
investigating
pathogenic
mechanisms
therapeutic
strategies
diseases.
This
review
aims
summarize
pathological
alterations
representative
animal
present
recent
studies
on
newly
discovered
autophagy-stimulating
interventions
models.
Finally,
opportunities,
difficulties,
future
directions
therapy
discussed.
Pharmacological Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100053 - 100053
Published: March 1, 2025
Neurodegenerative
diseases
(NDs),
such
as
Alzheimer
disease,
Parkinson
Huntington
amyotrophic
lateral
sclerosis,
and
frontotemporal
dementia,
are
well
known
to
pose
formidable
challenges
for
their
treatment
due
intricate
pathogenesis
substantial
variability
among
patients,
including
differences
in
environmental
exposures
genetic
predispositions.
One
of
the
defining
characteristics
NDs
is
widely
reported
be
buildup
misfolded
proteins.
For
example,
disease
marked
by
amyloid
beta
hyperphosphorylated
Tau
aggregates,
whereas
exhibits
α-synuclein
aggregates.
Amyotrophic
sclerosis
dementia
exhibit
TAR
DNA-binding
protein
43,
superoxide
dismutase
1,
fused-in
sarcoma
involves
mutant
huntingtin
polyglutamine
These
proteins
key
biomarkers
also
serve
potential
therapeutic
targets,
they
can
addressed
through
autophagy,
a
process
that
removes
excess
cellular
inclusions
maintain
homeostasis.
Various
forms
macroautophagy,
chaperone-mediated
microautophagy,
hold
promise
eliminating
toxic
implicated
NDs.
In
this
review,
we
focus
on
elucidating
regulatory
connections
between
autophagy
NDs,
summarizing
cause
exploring
impact
mechanisms,
discussing
how
regulate
aggregation.
Moreover,
underscore
activation
strategy
across
different
small
molecules
capable
activating
pathways,
rapamycin
targeting
mTOR
pathway
clear
Sertraline
AMPK/mTOR/RPS6KB1
Tau,
further
illustrate
NDs'
intervention.
Together,
these
findings
would
provide
new
insights
into
current
research
trends
propose
small-molecule
drugs
promising
strategies
future
ND
therapies.
SIGNIFICANCE
STATEMENT:
This
review
provides
an
in-depth
overview
eliminate
aggregates
neurodegenerative
diseases.
It
elucidates
fascinating
interrelationships
"chasing
escaping"
phenomenon.
discusses
progress
utilizing
activate
improve
efficacy
therapies
removing
Medicinal Plant Biology,
Journal Year:
2024,
Volume and Issue:
3(1), P. 0 - 0
Published: Jan. 1, 2024
The
Lonicera
genus
with
medicinal
and
edible
characteristics
is
a
rich
source
of
bioactive
compounds
that
together
account
for
numerous
health
benefits.
Plants
within
this
have
been
used
traditionally
in
China
to
treat
heat-related
illnesses,
viral
respiratory
infections,
skin
diseases,
inflammation
thousands
years.
main
include
chlorogenic
acids,
flavonoids,
iridoids,
triterpene
saponins.
Aside
from
the
role
as
valuable
resource,
constituent
members
also
food
cosmetic
industries.
Due
huge
demand
plants
propensity
overexploitation
wild
resources
Lonicera,
there
need
meet
via
alternative
efficient
strategies
such
metabolic
engineering
green
production.
Here,
we
provide
comprehensive
review
relevant
scientific
literature
covering
structure,
pharmacology,
multi-omics
analyses,
phylogenetic
analysis,
biosynthesis,
constituents
genus.
Finally,
proffer
suggestions
on
prospects
fully
exploiting
utilizing
useful
plant
resources.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 19, 2024
Hederagenin
(HG)
is
a
natural
pentacyclic
triterpenoid
that
can
be
isolated
from
various
medicinal
herbs.
By
modifying
the
structure
of
HG,
multiple
derivatives
with
superior
biological
activities
and
safety
profiles
have
been
designed
synthesized.
Accumulating
evidence
has
demonstrated
HG
its
display
pharmacological
against
cancers,
inflammatory
diseases,
infectious
metabolic
fibrotic
cerebrovascular
neurodegenerative
depression.
Previous
studies
confirmed
combat
cancer
by
exerting
cytotoxicity,
inhibiting
proliferation,
inducing
apoptosis,
modulating
autophagy,
reversing
chemotherapy
resistance
in
cells,
action
targets
involved
mainly
include
STAT3,
Aurora
B,
KIF7,
PI3K/AKT,
NF-κB,
Nrf2/ARE,
Drp1,
P-gp.
In
addition,
antagonize
inflammation
through
production
release
pro-inflammatory
cytokines
mediators
regulating
inflammation-related
pathways
targets,
such
as
MAPK,
JAK2/STAT3,
Keap1-Nrf2/HO-1,
LncRNA
A33/Axin2/β-catenin.
Moreover,
anti-pathogen,
anti-metabolic
disorder,
anti-fibrosis,
neuroprotection,
anti-depression
mechanisms
partially
elucidated.
The
diverse
properties
hold
significant
implications
for
future
research
development
new
drugs
derived
which
lead
to
improved
effectiveness
profiles.
RSC Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
14(10), P. 1858 - 1884
Published: Jan. 1, 2023
By
integrating
and
analyzing
external
related
literature
reports,
the
latest
research
progress
on
resource
distribution,
pharmacological
effects
structural
modification
of
hederagenin
was
reviewed.
