Enhancing radiotherapy in triple-negative breast cancer with hesperetin-induced ferroptosis via AURKA targeting nanocomposites DOI Creative Commons

Yang Guo,

Huan Wang, Xinlei Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 30, 2024

Language: Английский

Citrus reticulata peel extract mitigates oxidative stress and liver injury induced by abamectin in rats DOI

Ahmed Rahib,

Mustafa M. Karhib,

Hoda M. Nasr

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 87, P. 102321 - 102321

Published: Feb. 3, 2024

Language: Английский

Citations

11
Effects of aging on the bioactive flavonoids and fungal diversity of Pericarpium Citri Reticulatae (Citrus reticulata ‘Chachi’) DOI Creative Commons

Linhong Chen,

Gengsheng Xiao,

Yujuan Xu

et al.

LWT, Journal Year: 2024, Volume and Issue: 200, P. 116135 - 116135

Published: May 1, 2024

Language: Английский

Citations

6
Identification and Characterization of Glycosyltransferases Involved in the Biosynthesis of Neodiosmin DOI
Xiaosa Chang,

Xueting Fang,

Yan Yao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(8), P. 4348 - 4357

Published: Feb. 14, 2024

Glycosylation plays a very important role in plant secondary metabolic modifications. Neodiosmin, identified as diosmetin-7-O-neohesperidoside, not only acts to mitigate bitterness and enhance the flavor of food but also serves pivotal metabolite that reinforces immunity. Investigating its biosynthetic pathway plants is crucial for optimizing fruit quality fortifying immune responses. In this study, through analysis transcriptomic data from Astilbe chinensis, we two novel uridine diphosphate (UDP)-glycosyltransferases (UGTs): Ach14791 (AcUGT73C18), responsible flavonoid 7-O-glycosylation Ach15849 (AcUGT79B37), involved flavonoid-7-O-glucoside-2″-O-rhamnosylation. By delving into enzymatic properties catalytic promiscuity, developed biosynthesis route neodiosmin by establishing one-pot enzyme-catalyzed cascade reaction. Simultaneously, lonicerin rhoifolin were successfully synthesized using same dual-enzyme Taken together, our findings UGTs provided biocatalytic components microorganism-based flavonoid-7-O-disaccharide compounds.

Language: Английский

Citations

5
Protective Effect of the Naringin–Chitooligosaccharide Complex on Lipopolysaccharide-Induced Systematic Inflammatory Response Syndrome Model in Mice DOI Creative Commons
Sheng Tang,

Zhu Ouyang,

Xiang Tan

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(4), P. 576 - 576

Published: Feb. 14, 2024

Naringin is one of the common flavonoids in grapefruit, which has anti-cancer, antioxidant, and anti-inflammatory activities. However, its poor solubility limits wide application. Therefore, aim this study to investigate effect naringin combined with chitooligosaccharides good biocompatibility by constructing a mouse model systemic inflammatory response syndrome (SIRS). The results showed that naringin-chitooligosaccharide (NG-COS) complex significantly inhibited lipopolysaccharide (LPS)-induced weight loss, reduced food intake, tissue infiltration, proinflammatory cytokines IL-6, TNF-α, INF-γ, IL-1β levels. also affected content malondialdehyde activities MPO, SOD, GSH liver, spleen, lungs, serum mice inflammation. In addition, NG-COS mRNA expression factors TLR4/NF-κB signaling pathway. Principal component analysis complexes could inhibit LPS-induced inflammation mice, was better than alone. This explored synergistic effects chitosan reducing contribute development novel biomedical interventions.

Language: Английский

Citations

4
Metabolite profiling and ‘dryness’-like effect analysis of ‘Chenpi’ plant tea (Citri Reticulatae Pericarpium peel) with and without steaming peocessing DOI
Zhenwei Lan, Xiaoting Zhang,

Xinhang Cai

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 206, P. 116089 - 116089

Published: Feb. 25, 2025

Language: Английский

Citations

0
The application of medicine and food homology in the management of chronic heart failure DOI Creative Commons
Haipeng Yin, Herong Cui, Zixuan Zhang

et al.

Journal of Traditional Chinese Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Hepatoprotective Effects of Citri reticulatae Pericarpium and Chaenomelese speciosa (Sweet) Nakai Extracts in Alcohol-Related Liver Injury: Modulation of Oxidative Stress, Lipid Metabolism, and Gut Microbiota DOI Creative Commons

Shuangshuang Ma,

Lingtao Kang,

Zhipeng Gao

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 343 - 343

Published: March 14, 2025

Chronic and excessive alcohol consumption induces alcohol-related liver injury (ALI), characterized by oxidative stress (OS), disrupted lipid metabolism, gut microbiota dysbiosis. Given the lack of effective pharmacological treatments, flavonoid-rich fruits have attracted growing attention as potential intervention strategies. This study investigated independent combined effects extracts from Citri reticulatae pericarpium (CRPE) Chaenomeles speciosa (Sweet) Nakai (CSPE), previously shown to possess hepatoprotective properties, in a mouse model ethanol-induced chronic ALI. The flavonoid composition CRPE CSPE was using LC-MS/MS, their mechanisms action were further elucidated through transcriptomic analysis. results showed that CSPE, whether administered individually or combination, effectively alleviated alcohol-induced hepatic histological damage inflammatory responses. Furthermore, both significantly reduced OS improved metabolism. Notably, CRPE, combination regulated microbiota, increased abundances beneficial bacteria such Lactobacillus Bifidobacterium, along with elevated levels short-chain fatty acids (SCFAs). These findings highlight combinations multiple fruit exhibit significant alleviating ALI modulating providing valuable insights for development functional foods.

Language: Английский

Citations

0
Hesperidin mitigated deoxynivalenol-induced liver injury by inhibiting ROS/ P53/ PGC-1α-mediated disruption of mitochondrial dynamics and PANoptosis DOI

Xin Wang,

Tong Nie,

Aqun Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156747 - 156747

Published: April 1, 2025

Language: Английский

Citations

0
17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance DOI Creative Commons
Ying Tian, Yuan Xie, Xinyu Hong

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e29013 - e29013

Published: April 1, 2024

After surgical or natural menopause, women face a high risk of nonalcoholic fatty liver disease (NAFLD), which can be diminished by hormone replacement therapy (HRT). The gut microbiota is subject to modulation various physiological changes and the progression diseases. This microbial ecosystem coexists symbiotically with host, playing pivotal roles in immune maturation, defense mechanisms, metabolic functions essential for nutritional homeostasis. E

Language: Английский

Citations

3
Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation DOI
Hao Chen,

Xintong Zhou,

Jun Ma

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135952 - 135952

Published: Sept. 24, 2024

Language: Английский

Citations

3