Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade DOI Creative Commons
Xin Yu, Juan Jiang, Li Cheng

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 20, 2024

Abstract Background Periprosthetic osteolysis and subsequent aseptic loosening are the leading causes of failure following total joint arthroplasty. Osteogenic impairment induced by wear particles is regarded as a crucial contributing factor in development osteolysis, with endoplasmic reticulum (ER) stress identified key underlying mechanism. Therefore, identifying potential therapeutic targets agents that can regulate ER adaption osteoblasts necessary for arresting loosening. Osthole (OST), natural coumarin derivative, has demonstrated promising osteogenic properties ability to modulate various diseases. However, impact OST on stress-mediated caused remains unclear. Methods TiAl 6 V 4 (TiPs) were sourced from prosthesis patients who underwent revision hip arthroplasty due A mouse calvarial model was utilized explore effects TiPs-induced vivo. Primary employed investigate osteoblast apoptosis inhibition TiPs vitro. The mechanisms OST-modulated alleviation elucidated through Molecular docking, immunochemistry, PCR, Western blot analysis. Results In this study, we found treatment effectively mitigated (TiPs)-induced enhancing osteogenesis model. Furthermore, observed could attenuate reduction exposed vitro Mechanistically, exerts bone-sparing stressed upon exposure specifically suppressing stress-dependent PERK signaling cascade. Conclusion ameliorates particle-induced mitigating via These findings suggest may serve agent combating impairment, offering novel alternative strategy managing

Language: Английский

Development of modern Chinese medicine guided by molecular compatibility theory DOI Creative Commons

Lifeng Luo,

Jieru Zhou,

Xiaonan Liu

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Traditional Chinese Medicine (TCM) has gained global attention, particularly after Professor Youyou Tu was awarded the Nobel Prize for her discovery of artemisinin as a treatment malaria. However, theory behind TCM is often perceived "black-box" with complex components and an unclear structure mechanism action. This had hindered development within framework modern medicine. The molecular compatibility proposed by Tian Xie's team integrates Western medicine in clinical practice, provide feasible direction modernization. It necessary to summarize popularize this theory. review aims systematically introduce some new insight TCM. According theory, desired effects can be achieved organically combining multiple active molecules from These compounds have specific ingredients, precise mechanisms, controllable quality that meet standards guided antitumor drug elemene emulsions, also revealed extensive between TCM-derived other TCM, medicine, or biomaterials. opens up potential TCM-based options. In conclusion, holds promise strategy modernizing

Language: Английский

Citations

7
Isorhapontigenin, a Potential Anti-Ad Natural Product by Multiple Pathways, Discovered Via Network Proximity and Gene Enrichment Analyses DOI
Pengfei Guo, Pengfei Guo, Jun Zhao

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dietary bitter ginger-derived zerumbone improved memory performance during aging through inhibition of the PERK/CHOP-dependent endoplasmic reticulum stress pathway DOI
Chuan Yang,

Meihuan Zhao,

Yuanyuan Chen

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(18), P. 9070 - 9084

Published: Jan. 1, 2024

PERK/CHOP pathway-mediated excessive endoplasmic reticulum (ER) stress is closely linked to aging-related cognitive impairment (ARCD). Zerumbone (ZB), a naturally occurring sesquiterpene molecule obtained from dietary bitter ginger, has garnered significant interest due its diverse range of biological properties. It unclear, though, if ZB can reduce ARCD by preventing ER that dependent on the pathway. Here, PERK-CHOP pathway was main focus an evaluation effects and mechanisms for attenuating in D-galactose (D-gal)-induced aging mice SH-SY5Y cells. According our findings, not only greatly decreased neuronal both

Language: Английский

Citations

2
Pathogenesis of Alzheimer's Disease and Therapeutic Strategies Involving Traditional Chinese Medicine DOI

Shutang Li,

Jinfei Yang

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Alzheimer's disease (AD) is a prevalent degenerative disorder affecting the central nervous system of elderly. Patients primarily manifest cognitive decline and non-cognitive neuro-psychiatric symptoms. Currently, western medications for AD include cholinesterase inhibitors glutamate receptor inhibitors, which have limited efficacy accompanied by significant toxic side effects. Given intricate pathogenesis AD, use single-target limited. In recent years, as research on has progressed, traditional Chinese medicine (TCM) its active ingredients increasingly played crucial role in clinical treatment. Numerous studies demonstrate that TCM can exert anti-Alzheimer's effects modulating pathological protein production deposition, inhibiting tau hyperphosphorylation, apoptosis, inflammation, oxidative stress, while enhancing cholinergic system, protecting neurons synapses, optimizing energy metabolism. This article summarizes extracts from briefly elucidates their pharmacological mechanisms against aiming to provide foundation further into specific prevention treatment disease, well identification efficacious ingredients.

Language: Английский

Citations

2
Construction of chrysophanol loaded nanoparticles with N-octyl-O-sulfate chitosan for enhanced nephroprotective effect DOI Creative Commons

Qingxue Wei,

Fuping Gao, Leiping Gao

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 193, P. 106685 - 106685

Published: Dec. 27, 2023

Natural occurring anthraquinone like chrysophanol has been studied because of its anti-diabetic, anti-tumor, anti-inflammatory, hepatoprotective and neuroprotective properties. Nonetheless, poor water solubility unstable nature are big concerns in achieving efficient delivery associated pharmacokinetic pharmacodynamic effects. Herein, this study sought to solve the above-mentioned problem through development chrysophanol-loaded nanoparticles enhance bioavailability evaluate anti-renal fibrosis effect rats. After synthesis a safe N-octyl-O-sulfate chitosan, we used it prepare dialysis technique before performed physical characterization. Also, tested stability for 21 days at 4 °C room temperature (25 °C) evaluated their pharmacokinetics rat model chronic kidney disease (CKD). In terms results, nano-preparation demonstrated an acceptable narrow size distribution, wherein encapsulation rate, size, polydispersed index (PDI) electrokinetic potential were respectively 83.41±0.89 %, 364.88±13.62 nm, 0.192±0.015 23.78±1.39 mV. During storage, observed that particles altered slightly but difference was statistically insignificant (p > 0.05). vitro release studies showed formulation reached 84.74 % 24 h. Chrysophanol 2.57-fold increase compared unformulated chrysophanol. More importantly, certain renal internalization properties effects, which could ultimately result reduced blood-urea nitrogen (BUN), kidney-injury molecule-1 (KIM-1) serum creatinine (SCr) levels conclusion, prepared potentially increased enhanced nephroprotective effects

Language: Английский

Citations

5
Network pharmacology and transcriptomics explore the therapeutic effects of Ermiao Wan categorized formulas for diabetes in mice DOI Creative Commons
Yuping Wang, Yimeng Chen, Xinyi Liang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 6, 2024

Ermiao wan (EMW) is a classical traditional Chinese medicine formula, with two modified versions including Sanmiao (SMW) and Simiao (FMW). These categorized formulas (ECFs) are traditionally used to treat gouty arthritis hyperuricemia. However, their potential benefits mechanisms on diabetes remain be explored. This study aims investigate the overall effects biological differences of ECFs in high fat diet (HFD)-fed mice based network pharmacology transcriptomics. significantly reduced body weight, improved oral glucose tolerance, decreased accumulation, lowered serum insulin inflammatory cytokine levels HFD-fed mice. FMW had better efficacy than EMW SMW. Network analysis revealed that targeted functional modules associated chronic inflammation, lipid metabolism, metabolism. Transcriptome results also showed could inhibit genes inflammation upregulated some Comprehensive QPCR verification indicated beneficial might attributed regulation Ddit3, Ccl2, Esr1, Cyp7a1. provides theoretical basis for clinical use ECFs.

Language: Английский

Citations

1
An Endophenotype Network Strategy Uncovers YangXue QingNao Wan Suppresses Aβ Deposition, Improves Mitochondrial Dysfunction and Glucose Metabolism DOI
Handong Wang,

Jinna Yang,

Xiaolian Zhang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156158 - 156158

Published: Oct. 16, 2024

Language: Английский

Citations

0
A novel herbal aromatic essential oil for treating Chemotherapy-Induced Nausea and Vomiting: a mass spectrometry and network pharmacology study of the traditional Chinese medicine formula DOI Creative Commons
Min Zhan,

Yuanfang Sun,

Jun Yan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 24, 2024

Abstract Objectives: This study aimed to investigate the substance basis and pharmacological mechanism of Dingxiang Shidi Decoction in preventing treating Chemotherapy-Induced Nausea Vomiting (CINV). Methods: We employed advanced analytical techniques including UPLC-MS/MS GC-MS analyze chemical components Decoction. Network pharmacology molecular docking were applied explore its mechanisms. Results: Our established a comprehensive composition database for Decoction, integrating qualitative components, network entries, comprising 292 compounds. Furthermore, we elucidated potential pharmacologically active pathways associated with alleviating CINV symptoms by These include inflammation reduction, modulation neurotransmitter stimulation gastrointestinal tract, regulation cellular proliferation differentiation. Notably, key ingredients, predominantly aromatic compounds such as sabinene, (-)-α-cubebene, α-copaene, β-caryophyllene, aromandendrene, γ-muurolene, (-)-α-muurolene, α-phellandrene, α-terpinene, γ-terpinene, (+)-δ-cadinene, Gomisin B, demonstrate significant binding affinity multiple targets, notably AKT1, BCL2, EGFR, MTOR, STAT3. Conclusions: sheds light on mechanisms treatment, providing valuable insights clinical application suggesting aromatherapy promising therapeutic approach. findings provide into multifaceted applications settings treatment chemotherapy-induced nausea vomiting.

Language: Английский

Citations

0
Creation of single App knock-in mouse models and of single MAPT knock-in models: Demonstration of Aβ-tau axis DOI
Takaomi C. Saido

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 105 - 136

Published: Jan. 1, 2024

Language: Английский

Citations

0
A Novel Network-Based Framework Forsynergistic Ingredients Discovery from Herb Medicines: Using Cough Variant Asthma Disease as an Example DOI
Jiaqi Yao, Yinyin Wang,

Yihang Sui

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0