The multiple mechanisms and therapeutic significance of rutin in metabolic dysfunction-associated fatty liver disease (MAFLD)

Fitoterapia, Journal Year: 2024, Volume and Issue: 178, P. 106178 - 106178

Published: Aug. 15, 2024

Language: Английский

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Activation of Nrf2 and FXR via Natural Compounds in Liver Inflammatory Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11213 - 11213

Published: Oct. 18, 2024

Liver inflammation is frequently linked to oxidative stress and dysregulation of bile acid fatty metabolism. This review focuses on the farnesoid X receptor (FXR), a critical regulator homeostasis, its interaction with nuclear factor erythroid 2-related 2 (Nrf2), key modulator cellular defense against stress. The explores interplay between FXR Nrf2 in liver inflammatory diseases, highlighting potential therapeutic effects natural agonists. Specifically, compounds such as auraptene, cafestol, curcumin, fargesone A, hesperidin, lycopene, oleanolic acid, resveratrol, rutin, ursolic withaferin A are reviewed for their ability modulate both pathways. article discusses alleviate inflammation, stress, damage diseases metabolic-associated disease (MAFLD), cholestatic injury, viral hepatitis. In addition, we address molecular mechanisms driving including immune responses, accumulation, while also summarizing relevant experimental models. emphasizes promising targeting pathways using compounds, paving way future treatments diseases. Finally, limitations clinical application were indicated, further research directions proposed.

Language: Английский

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A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 4202 - 4229

Published: June 26, 2024

Abstract Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid disorders with diverse etiology rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, mechanisms related to peroxisome proliferator‐activated receptors, nuclear factor kappa‐B, AMP‐activated protein kinase, (erythroid‐derived 2)‐like 2, transporter type 4, phosphatidylinositol‐3‐kinase/protein kinase B pathway. However, comprehensive summary flavonoid effects on GLMD lacking. This study reviewed roles natural different structures treatment reported globally past 5 years provides reference for developing as drugs treating GLMD.

Language: Английский

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Galactooligosaccharide-Metabolism-Related Genes of Bifidobacterium pseudocatenulatum Contribute to the Regulation of Glucose and Lipid Metabolism in Type 2 Diabetic Mice

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

This study investigated whether the galactooligosaccharide (GOS)-metabolism-related genes (GOS-cluster) in

Language: Английский

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ALOX15 Aggravates Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice with Type 2 Diabetes via Activating the PPARγ/CD36 Axis

Antioxidants and Redox Signaling, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent hepatic disorder worldwide. Arachidonic acid 15-lipoxygenase (ALOX15), an enzyme catalyzing the peroxidation of polyunsaturated fatty acids, plays crucial role in various diseases. Here, we sought to investigate involvement ALOX15 MASLD. Results: In this study, observed upregulation high-fat diet (HFD)- and streptozotocin (STZ)-induced mice. Metabolomic analysis revealed elevated levels metabolites, 12(S)-hydroperoxyeicosatetraenoic 15(S)-hydroperoxyeicosatetraenoic acid. Transcriptomic showed that increased uptake regulated by PPARγ/CD36 pathway predominated lipid accumulation. To elucidate mechanism underlying ALOX15-induced accumulation, HepG2 cells were transfected with lentivirus expressing or small interfering RNA targeting exposed palmitic (PA). Both overexpression PA exposure led intracellular free triglyceride, resulting lipotoxicity. aggravated effect PA, while knockdown attenuated PA-induced Moreover, treatment PPARγ antagonist GW9662 CD36 inhibitor sulfosuccinimidyl oleate sodium effectively reduced accumulation lipotoxicity from exposure, indicating ALOX15-mediated Furthermore, liraglutide, widely used glucagon-like peptide 1 receptor (GLP-1R) agonist (GLP-1RA), improved HFD/STZ-induced mice suppressing ALOX15/PPARγ/CD36 pathway. Innovation Conclusion: Our study underscores potential as emerging therapeutic target for addition, GLP-1RA may confer hepatoprotection regulating ALOX15, enhancing our comprehension mechanisms underpinning their protection on Antioxid. Redox Signal. 00, 000-000.

Language: Английский

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The Effects of a Food Supplement, Based on Co-Micronized Palmitoylethanolamide (PEA)–Rutin and Hydroxytyrosol, in Metabolic Syndrome Patients: Preliminary Results

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 413 - 413

Published: Jan. 23, 2025

Background: Metabolic syndrome (MetS) patients have impaired hypothalamic regulatory functions involved in food intake and energy expenditure suffer from a state of meta-inflammation. Pre-clinical studies demonstrated that ultramicronized palmitoylethanolamide (PEA) acts both on the adipose tissue central nervous system, while hydroxytyrosol (HTyr) counteracts several types dysmetabolism. Objectives: The aim our randomized crossover double-blind placebo-controlled pilot study was to evaluate potential effects supplement (FS) containing co-micronized formulation PEA rutin along with HTyr, combined tailored calorie-controlled Mediterranean diet, MetS. Methods: Nineteen were enrolled block-randomized an eight-week MD together FS or placebo. After two-week washout period, treatments reversed. Data laboratory parameters those detected by capillary sampling, anthropometry, body composition analysis, ultrasound examination, blood pressure monitoring, 36-Item Short-Form Health Survey questionnaire, handgrip strength test, physical performance tests collected at each time point (protocol code R.S. 262.22, registered 20 December 2022). Results: At end study, supplemented showed significant reduction weight, mass index, fat mass, inflammation biomarkers (CRP ESR), compared placebo-supplemented patients. In contrast, fat-free phase angle, cell increased placebo Conclusions: Although preliminary, results clinical suggest PEA–rutin HTyr may be help against adiposopathy

Language: Английский

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Unveiling the Dark Side of Flavonoid: Rutin Provokes Hepatotoxicity in Low-Dose 2-Amino-3-methylimidazo [4,5-f] Quinoline-Exposed Mice via Regulating Gut Microbiota and Liver Metabolism

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

2-Amino-3-methylimidazole [4,5-f] quinoline (IQ) is a kind of heterocyclic amine (HCAs) with high carcinogenicity in hot processed meat. Rutin (Ru) flavonoid compound anti-inflammatory and antioxidant properties. However, whether Ru scatheless under IQ-stimulated potential unhealthy conditions, especially liver function, vivo, unknown. In this study, we explored the effects underlying mechanism on injury induced by low dose IQ mice. Results showed that supplement led to upon low-dose alone administration, as shown histological analysis, inflammatory, serum biochemical indexes. Additionally, nontargeted metabolomics analysis revealed coexposure disrupted metabolic balance, leading significant changes metabolites pathways, hinting at possible relationship intestinal microbiota. Furthermore, 16S rRNA sequencing data indicated combination caused gut microbiota dysbiosis decreased level short-chain fatty acids (SCFAs). Correlation between microbiota, SCFAs, metabolites, damage markers highlighted crucial role gut-liver axis coexposure-induced vivo. general, study offers valuable perspective flavones HCA compounds realms food safety human health.

Language: Английский

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Fucoidan and chitosan electrostatically coated nanoliposomes enhance physicochemical stability and bioavailability of rutin

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140450 - 140450

Published: Jan. 1, 2025

Language: Английский

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Diet, oxidative stress and MAFLD: a mini review

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 4, 2025

Globally, metabolic dysfunction-associated fatty liver disease (MAFLD), also known as non-alcoholic (NAFLD) or steatotic (MASLD), is a common chronic disease. The progression of MAFLD leads to vicious cycle in which oxidative stress results from the that augmenting de-novo lipid levels and increases steatosis. Most non-enzymatic antioxidants are present food. Therefore, review summarizes findings studies on food-derived presents an stress-related regulatory network MAFLD, offering new ideas for prevention treatment.

Language: Английский

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Folic acid intervention ameliorates hepatic steatosis after long-term alcohol exposure by alleviating endoplasmic reticulum stress

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109896 - 109896

Published: March 1, 2025

Language: Английский

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