The Significant Technical Mantle of AI in the Field of Secular Engineering: an Innovative Design

Published: May 14, 2024

Language: Английский

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The Treatment of Keloid Scars via Modulating Heterogeneous Gelatin-Structured Composite Microneedles to Control Transdermal Dual-Drug Release

Polymers, Journal Year: 2022, Volume and Issue: 14(20), P. 4436 - 4436

Published: Oct. 20, 2022

Keloid scarring is an abnormal scar disease characterised by excessive proliferation of fibroblasts and over-deposition collagen during wound healing. Although various treatments for keloid scars have been developed, preventive medicine believed to be a promising strategy. The skin barrier limits the gentle topical administration medicaments such as creams hydrogel dressings, resulting in reduced therapeutic efficacy. In recent years, microneedles (MNs) regarded appreciable device without inducing side effects, they are painless do not cause bleeding. this study, MN patch with controlled transdermal dual-drug release was developed achieve combinatory treatment using heterogeneous gelatin-structured composite MN. Gelatin used substrate load gallic acid (GA) quercetin-loaded amphiphilic gelatin nanoparticles fabricate MNs. results insertion test mechanical properties MNs showed that patches could self-pressed into stratum corneum control at different time periods. GA released earlier stage retard fibroblasts, quercetin later strong antioxidant erase generation reactive oxygen species. Furthermore, real-time quantitative polymerase chain reaction data indicated gene expression (such Col I III) downregulated system. above demonstrate combination pharmacology beneficial preventing formation.

Language: Английский

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Nano Drug Delivery Strategies for an Oral Bioenhanced Quercetin Formulation

European Journal of Drug Metabolism and Pharmacokinetics, Journal Year: 2023, Volume and Issue: 48(5), P. 495 - 514

Published: July 31, 2023

Language: Английский

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Nanogels Based on Hyaluronic Acid as Potential Active Carriers for Dermatological and Cosmetic Applications

Cosmetics, Journal Year: 2023, Volume and Issue: 10(4), P. 113 - 113

Published: Aug. 7, 2023

Nanogels are a prominent research topic in biomedical and drug delivery applications. The versatility of their chemistry allows them to be tailored both carry release wide range active molecules, target specific tissues or cell types. Within vast field possible chemical designs, nanogels based on hyaluronic acid seem particularly interesting from the standpoint dermatological cosmetic applications, due well-known involvement several fundamental processes related skin health ageing. In spite this, relatively few studies about these nanocarriers potential skin-related benefits have appeared so far literature. With aim stimulate further interest topic, this review, we provide information acid-based nanogels, including key physicochemical properties, typical behavior, main synthetic methodologies. latter include: approaches spontaneous self-assembly polymer molecules; cross-linking, where nanogel formation is promoted by covalent bonds between chains; hybrid that leverage combination above two mechanisms. We believe body information, which collected going through relevant literature past 10–15 years, offers formulators plenty options design innovative products.

Language: Английский

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Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1724 - 1724

Published: June 14, 2023

Atopic dermatitis (AD) is a chronic eczematous inflammatory disease that may arise from environmental, genetic, and immunological factors. Despite the efficacy of current treatment options such as corticosteroids, approaches are mainly focused on symptom relief present certain undesirable side effects. In recent years, isolated natural compounds, oils, mixtures, and/or extracts have gained scientific attention because their high efficiency moderate to low toxicity. promising therapeutic effects, applicability healthcare solutions somewhat limited by instability, poor solubility, bioavailability. Therefore, novel nanoformulation-based systems been designed overcome these limitations, thus enhancing potential, promoting capacity drugs properly exert action in AD-like skin lesions. To best our knowledge, this first literature review has summarizing loaded with ingredients, specifically for management AD. We suggest future studies should focus robust clinical trials confirm safety effectiveness natural-based nanosystems, paving way more reliable AD treatments.

Language: Английский

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Nanostructured Lipid Carriers Enriched Hydrogels for Skin Topical Administration of Quercetin and Omega-3 Fatty Acid

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2078 - 2078

Published: Aug. 3, 2023

Chronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing damage aging. Because of their well-known skincare protective benefits, quercetin (Q) omega-3 fatty acids (ω3) have attracted the attention dermocosmetic pharmaceutical sectors. However, both bioactives inherent properties that limit efficient delivery. Therefore, nanostructured lipid carriers (NLCs) enriched PFC® hydrogels (HGs) been developed as a dual-approach vehicle for Q and/or ω3 topical administration improve bioactives’ stability permeation. Two NLC formulations were prepared with same composition but differing in surfactant (NLC1—soy lecithin poloxamer 407; NLC2—Tween® 80 dioctyl sodium sulfosuccinate (DOSS)), which an impact on physicochemical therapeutic performance. Despite NLCs presenting high loading capacity, NLC2′s make them more suitable ensure longer colloidal stability. Additionally, NLC2 demonstrated sustained release, indicating higher bioactive storage while improving permeability. The occlusive effect NLCs-enriched HGs also has positive Q-loaded NLC2, or without ω3, -enriched efficacy antioxidant photoprotective well effective reduction S. aureus growth, they constitute promising approach prevent aging other damaging cutaneous processes.

Language: Английский

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Advancement of Nanoengineered Flavonoids for Chronic Metabolic Diseases

Published: Aug. 27, 2024

The increasing occurrence of chronic metabolic diseases (CMDs) presents a substantial public health challenge worldwide, necessitating the development pioneering therapeutic approaches. Flavonoids, which are naturally occurring compounds, exert broad spectrum biological activities, encompassing their anti-inflammatory, anti-diabetic, and antioxidant properties, among others. Though they have potential role in treating CMDs, face challenges extraction purification, poor gastrointestinal absorption, low solubility, rapid metabolism, impede clinical applicability. Nanotherapeutics has been receiving significant attention as it aids resolving these issues. Hence, purpose this chapter is to shed light on advances different nanoengineered formulations flavonoids. commences with an outline diseases, emphasizing prevalence pressing need for innovative therapeutics strategies address burden. Following this, flavonoids conditions discussed. Moreover, also elucidates nanoengineering accomplishing efficient flavonoid delivery, particular emphasis versatile nanoformulations, such liposomes, solid lipid nanoparticles, phytosomes. Next, we discuss optimization techniques, surface modification enhance targeting stability, controlled release approaches sustained effects, synergistic outcomes. enhancement bioavailability stability addressed, overcome barriers, targeted delivery site-specific action, methods prevent degradation. Subsequent sections elucidate managing focusing obesity, diabetes, cardiovascular disorders. mechanisms action impact systems efficacy highlighted, providing valuable insights. It highlights involved applicability discusses issues."

Language: Английский

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Lipid Nanovesicles for Antioxidant Delivery in Skin: Liposomes, Ufasomes, Ethosomes, and Niosomes

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1516 - 1516

Published: Dec. 12, 2024

The skin, being the largest organ of human body, serves as primary barrier against external insults, including UV radiation, pollutants, and microbial pathogens. However, prolonged exposure to these environmental stressors can lead generation reactive oxygen species (ROS), causing oxidative stress, inflammation, ultimately, skin aging diseases. Antioxidants play a crucial role in neutralizing ROS preserving health by preventing damage. In recent years, nanotechnology has emerged powerful tool for enhancing delivery antioxidants onto skin. particular, liposomal formulations have offered unique advantages such improved stability, controlled release, enhanced penetration through barrier. This led surge research focused on developing liposomal-based antioxidant systems tailored applications. Through comprehensive analysis literature from 2019–2024 period, this review provides an overview emerging trends use developed aimed at improving health. It explores latest advancements formulation strategies, vesicle characterization, their applications delivering combat stress-induced damage other associated pathologies. A comparison various is conducted most common antioxidants. Finally, brief lipid nanovesicles used cosmeceutical industry provided.

Language: Английский

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Revolutionizing Parkinson’s treatment: Harnessing the potential of intranasal nanoemulsions for targeted therapy

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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The potential use of the standardized Euterpe oleracea (açaí) seed extract in cosmetic products

International Journal of Cosmetic Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Objective The açaí ( Euterpe oleracea ), a palm tree fruit native to the Amazon region, holds significant potential for various applications in food, therapeutics and cosmetics. However, seeds of fruit, known contain numerous antioxidants, are discarded frequently cause environmental pollution. Therefore, this study aimed explore application standardized extract (TI‐35) as cosmetic product. Methods Açai were obtained from commercial source. Following preparations phytochemical identification quantification main constituents present (TI‐35), several vitro studies performed using human cell line cultures. TI‐35 was evaluated on viability (human keratinocytes, fibroblasts melanocytes), proliferation (keratinocytes), antioxidant activity (keratinocytes fibroblasts), melanin content (melanocytes), metalloproteinase‐1 (MMP‐1) tyrosinase inhibition assays. Skin irritation assessed reconstructed epidermis mutagenic evaluated, according OECD 439 471, respectively. Results A total 14 constituents, mainly phenolic compounds, identified quantified TI‐35. It demonstrated excellent long‐lasting stability exhibited intrinsic surpassing that ascorbic acid. At low concentrations (up 10 μg/mL), did not change or proliferation. decreased basal reactive oxygen species production produced pronounced scavenging effects. Notably, caused MMP‐1 its effect more when compared with either acid ferulic acid, highlighting pro‐aging property. In addition, interfere levels have skin has no activity, providing solid assurance safety E. use. Conclusion TI‐35, sourced seeds, by‐product food industry, noteworthy pharmacological properties vitro, including antioxidant, photoprotective, soothing sagging Thus, emerges safe option development innovative products.

Language: Английский

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