Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy

Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 229 - 255

Published: Sept. 1, 2024

Natural products have proven to be promising anti-cancer agents due their diverse chemical structures and bioactivity.This review examines central role in cancer treatment, focusing on mechanisms of action therapeutic benefits.Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids polyphenols, which exhibit various anticancer properties.These compounds induce apoptosis, inhibit cell proliferation cycle progression, interfere with microtubule formation, act topoisomerase targets, angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance activate immune cells.Herbal drugs offer advantages, particularly selective toxicity against cells, reducing adverse side effects associated conventional chemotherapy.Recent studies clinical trials highlight benefits herbal medicines alleviating effects, improving tolerance chemotherapy occurrence synergistic treatments.For example, medicine SH003 was found safe potentially effective treatment solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients advanced cancer.The current research landscape is extensive.Numerous investigating efficacy, safety cancers lung, prostate, breast hepatocellular carcinoma.Promising developments include polypharmacological approach, combination therapies, immunomodulation improvement quality life.However, there still challenges development use natural drugs, need further into action, possible interactions optimal dosage.Standardizing extracts, bioavailability delivery, overcoming regulatory acceptance hurdles critical issues addressed.Nonetheless, warrant investigation development.Multidisciplinary collaboration essential advance therapy integrate these mainstream treatment.

Language: Английский

---

Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

---

Exploring Synergistic Interactions between Natural Compounds and Conventional Chemotherapeutic Drugs in Preclinical Models of Lung Cancer

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 598 - 598

Published: May 8, 2024

In the current work, synergy between natural compounds and conventional chemotherapeutic drugs is comprehensively reviewed in light of preclinical research findings. The prognosis for lung cancer patients poor, with a 5-year survival rate 18.1%. use combination has gained significant attention as potential novel approach treatment cancer. present work highlights importance finding more effective therapies to increase rates. Chemotherapy primary option but it limitations such reduced effectiveness because cells become resistant. Natural isolated from medicinal plants have shown promising anticancer or chemopreventive properties their synergistic effect been observed when combined therapies. an anti-cancer drug compound exhibits effects, enhancing overall therapeutic actions against cells. conclusion, this provides overview latest on plant-derived alternative complementary options chemotherapy discusses treating minimal side effects.

Language: Английский

---

Apoptosis Induction and S-Phase Cell Cycle Blockade in Human Lung Adenocarcinoma Cell Line (A549) by Chlorophytum comosum (Thunb.) Jaques

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Methods The ethanolic roots (CCRE) and leaves (CCLE) extracts were interrogated for their apoptotic potential against human lung adenocarcinoma cell line (A549) using DNA fragmentation, Annexin V-FITC/PI staining apoptosis assay cycle analysis flow cytometry. Results Our results revealed significant damage induced death in A549 on treatment with active concentrations (40 µg/ml 80 µg/ml) of the S phase arrest. Conclusions This is first study demonstrating inducing chemically characterized bioactive compounds present from Chlorophytum comosum non-small line. concludes that can be a candidate natural isolated, clinically evaluated development novel naturally derived anti-cancer drugs cancer.

Language: Английский

---

Chemopreventive and therapeutic effects of Hippophae rhamnoides L. fruit peels evaluated in preclinical models of breast carcinoma

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Background Cancer remains a major global health challenge, necessitating innovative prevention and treatment approaches. Certain plants, adapted to specific environments, may exhibit bioactive properties with potential anticancer applications. Hypothesis Seaberry ( Hippophae rhamnoides L. ) fruit peels exert effects in breast carcinoma (BC) models through the additive or synergistic actions of their unique secondary metabolites. Methods H. peel extracts were analyzed using LC-DAD-MS LC-DAD techniques profile content carotenoids flavonoids, respectively. The preclinical study evaluated seaberry BC models: (1) syngeneic 4T1 mouse adenocarcinoma model (triple-negative), (2) rat chemically induced mammary carcinogenesis, (3) vitro studies MCF-7 (hormone receptor-positive) MDA-MB-231 (triple-negative) cell lines. Results analyses identified dominant metabolites, including isorhamnetin, quercetin glycosides, kaempferol catechin, zeaxanthin, lutein. In model, resulted significant, dose-dependent reduction tumor volume (43% 48% compared controls) decrease mitotic activity index. Serum cytokine analysis showed reductions IL-6, IL-10, TNF-α. chemopreventive high-dose improved cancer prognosis by reducing ratio poorly differentiated tumors increasing caspase-3 Bax expression while decreasing Ki-67 malondialdehyde levels. Both doses elevated Bax/Bcl-2 reduced stem markers CD44, EpCam, VEGF controls. Epigenetic revealed histone modifications (H4K16ac, H4K20me3) altered methylation tumor-suppressor genes (PITX2, RASSF1, PTEN, TIMP3). Microarray (758 miRNAs) beneficial changes nine oncogenic/tumor-suppressive miRNAs, miR-10a-5p, miR-322-5p, miR-450a-5p, miR-142-5p, miR-148b-3p, miR-1839-3p, miR-18a-5p, miR-1949, miR-347. , ethanolic extract conferred partial resistance cisplatin-induced cytotoxicity cells at IC 50 concentrations. Conclusion This rodent shows promising data but requires rigorous, long-term validation. Integrating plant-based nutraceuticals into oncology necessitates precise cancer-type profiling patient stratification for effective personalized treatments.

Language: Английский

---

Cancer and Traditional Medicine: An Integrative Approach

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 644 - 644

Published: April 28, 2025

Despite numerous advances in treatment, cancer still remains a leading cause of death worldwide. Given the significant health and economic burden this disease imposes, it is important to explore more effective treatment strategies. A major drawback conventional therapies persistence drug resistance, adverse reactions chemotherapy, digestive damage, reduced quality life, high costs. To address these challenges, researchers have been investigating utility using complementary alternative medicine (CAM) alongside treatments. Some CAM approaches reported enhance patients’ life reduce severity effects from therapies. This review explores traditional Chinese, Korean, Indian, Japanese, South African medicines as supportive for We also discuss concept integrative oncology its global relevance, typically emphasize whole-person care, including diet, lifestyle, mental/emotional well-being. In addition, we identify key active phytochemicals herbal used systems treatment. Our discussion aims provide foundation future research into oncology, fostering an interdisciplinary approach management.

Language: Английский

---

Empowering lung cancer treatment: Harnessing the potential of natural phytoconstituent‐loaded nanoparticles

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3899 - 3920

Published: May 28, 2024

Abstract Lung cancer, the second leading cause of cancer‐related deaths, accounts for a substantial portion, representing 18.4% all cancer fatalities. Despite advances in treatment modalities such as chemotherapy, surgery, and immunotherapy, significant challenges persist, including chemoresistance, non‐specific targeting, adverse effects. Consequently, there is an urgent need innovative therapeutic approaches to overcome these limitations. Natural compounds, particularly phytoconstituents, have emerged promising candidates due their potent anticancer properties relatively low incidence effects compared conventional treatments. However, inherent poor solubility, rapid metabolism, enzymatic degradation hinder clinical utility. To address obstacles, researchers increasingly turned nanotechnology‐based drug delivery systems (DDS). Nanocarriers offer several advantages, enhanced stability, prolonged circulation time, targeted tumor sites, thereby minimizing off‐target By encapsulating phytoconstituents within nanocarriers, aim optimize bioavailability efficacy while reducing systemic toxicity. Moreover, integration nanotechnology with allows nuanced understanding intricate molecular pathways involved lung pathogenesis. This integrated approach holds promise modulating key cellular processes implicated growth progression. Additionally, by leveraging synergistic seek develop tailored strategies that maximize In conclusion, nanocarriers represents avenue advancing treatment. has potential revolutionize current paradigms offering targeted, efficient, minimally toxic interventions. Continued research this field improving patient outcomes addressing unmet needs management.

Language: Английский

---

Astilbin Inhibits the Proliferation and Induces Apoptosis of Gastric Cancer Cells (AGS) by Targeting the Key Inflammatory Markers

Pharmacognosy Magazine, Journal Year: 2024, Volume and Issue: 20(4), P. 1276 - 1285

Published: Aug. 16, 2024

Background The predisposition toward gastrointestinal disease is increasing as a result of dietary changes and overindulgence in food preparation. Ninety percent stomach cancers are adenocarcinomas, type cancer the tract that leading cause mortality worldwide. Purpose Astilbin, natural dihydroflavonol substance derived from range foods medicinal herbs, has been shown current study to have anticancer potential against gastric AGS cell lines. Materials Methods half maximal inhibitory concentration value was determined after astilbin given lines at various doses. To verify apoptosis, astilbin-treated line subsequently stained with dual dye acridine orange/ethidium bromide. lines, enzyme-linked immunosorbent assay (ELISA) approach also used investigate inflammatory cytokines. Using ELISA, apoptotic marker expression including Bcl-2-associated X-protein, caspase-9 proteins, B-cell lymphoma 2 assessed cells treated astilbin. Results study’s findings reveal prime candidate for therapy since it causes apoptosis stronger effect on major markers disease. Conclusion provides comprehensive methodologies tools predicting absorption, distribution, metabolism, excretion, toxicity properties, facilitating informed decision-making development optimization therapy.

Language: Английский

---

Photoactive metabolite mediated photodynamic therapy of Rhabdomyosarcoma cell lines using medicinal plants and Doxorubicin co-treatments

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 15, 2024

Medicinal plant-mediated combinational therapies have gained importance globally due to minimal side effects and enhanced treatment outcomes compared single-drug modalities. We aimed analyze the cytotoxic potential of each conventional i.e., photodynamic therapy (PDT), chemotherapy (doxorubicin hydrochloride; Dox-HCl) with or without various concentrations medicinal plant extracts (PE) on soft tissue cancer Rhabdomyosarcoma (RD) cell line.

Language: Английский

---

Cytotoxic, antioxidant, and antiglycation activities, and tyrosinase inhibition using silver nanoparticles synthesized by leaf extract of Solanum aculeatissimum Jacq

Journal of Toxicology and Environmental Health, Journal Year: 2023, Volume and Issue: 87(2), P. 57 - 76

Published: Nov. 6, 2023

The present study aimed to determine the biological properties of an extract Solanum aculeatissimum aqueous (SaCE) alone as well silver nanoparticles (AgNPs) generated by green synthesis utilizing S. (SaCE). These synthesized SaCE AgNPs were characterized using UV-VIS spectrophotometry, scanning transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), zeta potential (ZP), dynamic light scattering (DLS). Determination total polyphenols, flavonoids, saponins content was conducted. In addition, high performance liquid chromatography-mass spectrometry (HPLC-MS) employed identify constituents in this extract. Antioxidant activity determined DPPH radical scavenging and ferric ion reducing power (FRAP) methods. Antiglycation demonstrated through relative mobility electrophoresis (RME) determination free amino groups. inhibitory on tyrosinase also examined. Molecular docking analyses performed assess molecular interactions with DNA tyrosinase. antitumor measured. Phytochemical analysis showed presence polyphenols (1000.41 293.37 mg gallic acid equivalent/g), flavonoids (954.87 479.87 rutin (37.89 23.01% saponins), particular steroidal (aculeatiside A B). Both exhibited significant antioxidant (respectively, 73.97%, 56.27% test, 874.67 837.67 μM Trolox Equivalent/g FRAP test) antiglycation activities (72.81 67.98% groups, results observed RME). presented 33.2, 36.1% tyrosinase, respectively. silico assay interaction between saponins, or action against various human tumor cells. Data that extracts from interest for application new therapeutic formulations medicine.

Language: Английский

---