5-Hydroxymethylfurfural derivatives with NO production inhibitory activity from the fruits of Schisandra chinensis

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: Jan. 23, 2025

Five previously unreported 5-hydroxymethylfurfural (5-HMF) derivatives, including chinenfurfurals A (1) and B (2) as 5-HMF-citric acid hybrids C–E (3–5) 5-HMF oligomers, well four known analogues (6–9), were isolated from the fruits of a well-known Chinese herbal species Schisandra chinensis. The structures these furfural compounds established by detailed analyses spectroscopic data especially HRMS NMR, it is first report type constituents title species. in vitro anti-inflammatory property them was further evaluated testing their inhibition against production nitric oxide lipopolysaccharide-activated murine RAW264.7 macrophages, compound 6 showed moderate activity with an IC50 41.2 µM. In addition, also suppressed expression two inflammation-related proteins, namely, inducible synthase cyclooxygenase-2.

Language: Английский

Chemical Constituents and Their Bioactivities of Plants from the Genus Eupatorium (2015–Present)

Biology, Journal Year: 2024, Volume and Issue: 13(5), P. 288 - 288

Published: April 24, 2024

The genus Eupatorium belongs to the Asteraceae (Compositae) family and has multiple properties, such as invasiveness toxicity, is used in folk medicine. last review on chemical constituents of this their biological activities was published 2015. present provides an overview 192 natural products discovered from 2015 present. These include 63 sesquiterpenoids, 53 benzofuran derivatives, 39 thymol 15 fatty acids, 7 diterpenoids, 5 monoterpenoids, 4 acetophenones, 6 other compounds. We also characterized respective structures cytotoxic, antifungal, insecticidal, antibacterial, anti-inflammatory, antinociceptive activities.

Language: Английский

Ingenane diterpenoids with anti-inflammatory activity from Euphorbia antiquorum

Fitoterapia, Journal Year: 2024, Volume and Issue: 180, P. 106350 - 106350

Published: Dec. 17, 2024

Language: Английский