International Journal of Cosmetic Science,
Journal Year:
2024,
Volume and Issue:
46(4), P. 526 - 543
Published: Aug. 1, 2024
Abstract
Ceramides
are
a
family
of
lipids
constituted
by
sphingoid
base
and
fatty
acid.
In
the
skin,
they
mainly
present
in
stratum
corneum
where,
with
cholesterol
free
acids,
constitute
inter‐corneocyte
lipids.
With
other
lipid
groups,
play
key
role
formation
dense
lamellar
structures
between
adjacent
corneocytes,
collectively
ensuring
vital
efficient
barrier
to
water
evaporation
protection
from
foreign
agents´
penetration.
Changes
ceramide
level
relative
composition,
potential
impairment
arrangement,
have
been
evidenced
different
skin
conditions
diseases.
Therefore,
use
suitably
formulated
ceramides
has
proposed
for
topical
treatment
help
re‐structure
damaged
arrangement
repair
impaired
function.
Nonetheless,
formulation
products
necessitates
specific
processes
such
as
heating
high
temperature
before
their
introduction
final
formula.
this
review
on
structure,
skincare,
we
point
out
necessity
rigorous
process
when
formulating
into
product.
We
demonstrate
counterproductive
effects
undissolved
capacity
formulas,
assessed
vitro
models
disrupted
barrier.
Journal of Cosmetic Dermatology,
Journal Year:
2024,
Volume and Issue:
23(4), P. 1452 - 1464
Published: Jan. 12, 2024
Abstract
Background
The
skin
condition
of
women
is
different
at
ages,
and
surface
lipids
are
also
different.
According
to
the
“7–7
theory”
Huangdi
Neijing,
physiological
changes
significantly
every
7
years,
aged
22–28
in
“4–7”
stage
as
mentioned
Neijing.
Women's
states
ages
produces
lipids.
Objectives
To
explore
key
that
contribute
differences
between
29–35
relationship
with
parameters
daily
routine.
Methods
Differential
were
detected
screened
year
old
(group
D1)
D2)
dry‐skinned
using
UPLC‐Q‐TOF‐MS
correlated
two
groups
questionnaires
based
on
basic
information,
lifestyle
habits,
work
situation,
emotional
stress.
Results
results
showed
all
eight
major
classes
had
highest
expression
D2
group,
largest
glycerophospholipids,
glycerol
esters,
fatty
acids.
BMI
value
group
was
higher
than
D1
elasticity
index
(R2)
brightness
(L,
a,
ITA
values)
lower
Cer
(d18:0/16:0)
positively
R2,
L,
ITA,
LMSP01080056
(N,N‐dimethyl‐Safingol)
b‐value,
LMSPGP03020013,
LMSPGP03020014,
LMSP03020024
negatively
R2.
Conclusions
Cer(d18:0/16:0)
a
neurosphingol
inhibits
elastase
expression.
N,N‐dimethyl‐Safingol
readily
undergoes
oxidation
form
yellow‐brown
solids.
macromolecular
structure
excessive
carbonyl
[LMGP0302]
susceptible
cross‐linking
stress
reactions,
which
accelerate
aging
reduce
elasticity,
thus,
they
may
be
contributing
age
groups.
The Journal of Physical Chemistry B,
Journal Year:
2024,
Volume and Issue:
128(22), P. 5378 - 5386
Published: May 28, 2024
The
extracellular
lipid
matrix
in
the
stratum
corneum
(SC)
plays
a
critical
role
skin
barrier
functionality,
comprising
three
primary
components:
ceramides,
cholesterol,
and
free
fatty
acids.
diverse
differentiated
by
molecular
structures
such
as
hydroxylations
varying
chain
lengths,
are
essential
for
matrix's
structural
integrity.
Recently,
new
subclass
of
ceramide,
1-O-acylceramide
NP
(CerENP),
has
been
identified;
however,
its
precise
SC
is
still
elusive.
Herein,
we
investigate
CerENP
on
structure
permeability
using
dynamics
simulations.
Our
findings
indicate
that
contributes
to
compact
lateral
dimension
our
model
with
repeat
distance
about
13
nm.
Additionally,
ethanol
assessments
show
effectively
reduces
penetration
through
matrix.
This
study
provides
an
insight
into
ceramide
SC,
enhancing
understanding
mechanisms
behind
dysfunction
diseases.
Tissue Barriers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 31, 2024
The
skin
is
the
largest
organ
of
human
body
and
widely
considered
to
be
first-line
defense
body,
providing
essential
protection
against
mechanical,
physical,
chemical
damage.
Keratinocytes
are
primary
cells
outer
layer
epidermis,
which
acts
as
a
mechanical
permeability
barrier.
epidermis
permanently
renewed
tissue
where
undifferentiated
keratinocytes
located
at
basal
proliferate
migrate
overlying
layers.
Here
we
report
that
some
components
affect
formation
differentiation
stratum
corneum,
most
specialized
epidermis.
International Journal of Cosmetic Science,
Journal Year:
2024,
Volume and Issue:
46(4), P. 526 - 543
Published: Aug. 1, 2024
Abstract
Ceramides
are
a
family
of
lipids
constituted
by
sphingoid
base
and
fatty
acid.
In
the
skin,
they
mainly
present
in
stratum
corneum
where,
with
cholesterol
free
acids,
constitute
inter‐corneocyte
lipids.
With
other
lipid
groups,
play
key
role
formation
dense
lamellar
structures
between
adjacent
corneocytes,
collectively
ensuring
vital
efficient
barrier
to
water
evaporation
protection
from
foreign
agents´
penetration.
Changes
ceramide
level
relative
composition,
potential
impairment
arrangement,
have
been
evidenced
different
skin
conditions
diseases.
Therefore,
use
suitably
formulated
ceramides
has
proposed
for
topical
treatment
help
re‐structure
damaged
arrangement
repair
impaired
function.
Nonetheless,
formulation
products
necessitates
specific
processes
such
as
heating
high
temperature
before
their
introduction
final
formula.
this
review
on
structure,
skincare,
we
point
out
necessity
rigorous
process
when
formulating
into
product.
We
demonstrate
counterproductive
effects
undissolved
capacity
formulas,
assessed
vitro
models
disrupted
barrier.
