
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: May 8, 2024
Language: Английский
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: May 8, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 28, 2024
Background Systemic immune-inflammatory biomarkers including systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and lymphocyte-to-monocyte (LMR) have been demonstrated to be associated with the risk severity of various liver diseases. However, studies on their role clinical significance in metabolic diseases, especially nonalcoholic fatty disease (NAFLD), are limited results inconsistent. Methods 10821 adults aged 20 years or older were enrolled this cross-sectional study, sourced from six cycles National Health Nutrition Examination Survey (NHANES). Survey-weighted logistic regression was employed investigate correlation between (SII, NLR, PLR, LMR) NAFLD risk. Restricted cubic spline models segmented used describe nonlinear relationships threshold effects. Subgroup sensitivity analyses also conducted. Results After adjusting for all confounding variables, there a significant positive association observed ln-transformed SII (OR= 1.46, 95% CI: 1.27-1.69, P < 0.001), NLR 1.25, 1.05-1.49, =0.015), LMR 1.39, 1.14-1.69, = 0.002) NAFLD. A dose-response relationship an inverted “U”-shaped 4.64 ln(PLR) When below 4.64, each unit increase 0.55-fold 1.55, 1.05-2.31, 0.05). Conversely, when exceeded 0.40-fold decrease 0.60, CI. 0.44-0.81, Conclusion SII, linearly showed
Language: Английский
Citations
43Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: April 8, 2024
Background Frailty is a significant concern in the field of public health. However, currently, there lack widely recognized and reliable biological markers for frailty. This study aims to investigate association between systemic inflammatory biomarkers frailty older adult population United States. Methods employed data from National Health Nutrition Examination Survey (NHANES) spanning 2007 2018 conducted rigorous cross-sectional analysis. We constructed weighted logistic regression models explore correlation Systemic Immune-Inflammation Index (SII), Inflammatory Response (SIRI), aged 40 80 years. Using restricted cubic spline (RCS), we successfully visualized relationship SII, SIRI, Finally, presented stratified analyses interaction tests covariates forest plot. Results involved 11,234 participants, 45.95% male 54.05% female, with an average age 64.75 ± 0.13 After adjusting relevant covariates, model indicated odds ratio (OR) 95% confidence interval(CI) natural logarithm (ln) transformed lnSII lnSIRI as 1.38 (1.24–1.54) 1.69 (1.53–1.88), respectively. Subsequently, assessed different levels lnSIRI, finding consistent results. In group model, likelihood significantly increased fourth quartile (OR = 1.82, CI: 1.55–2.12) compared second quartile. third 1.30, 1.10–1.53) 2.29, 1.95–2.70) The results indicate that income-to-poverty influence RCS demonstrated nonlinear lnSII, Conclusion this positive (SII, SIRI)
Language: Английский
Citations
9BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 29, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a primary cause of chronic disease, with potential progression to cirrhosis and hepatocellular carcinoma (HCC). Although systemic inflammatory biomarkers are associated diseases, their specific role in MASLD remains unclear. This study examines the association between MASLD. cross-sectional enrolled 6613 adults aged 20 years or older from National Health Nutrition Examination Survey (NHANES) spanning 2017 March 2020. Among these participants,, 34.67% were 40-59 years, 50.85% female, 63.26% Non-Hispanic White. We investigated 10 biomarkers: ALI, SIRI, SII, SIPS, IBI, NLR, PLR, CAR, LMR, PNI. Logistic regression models performed assess linear Restricted cubic spline (RCS) was employed explore nonlinear relationships risk. Additionally, subgroup analyses conducted examine influence various demographic clinical characteristics on observed associations. After adjusting for key confounders, NLR PLR exhibited negative risk, while PNI opposite (P < 0.05). Most biomarkers, including PNI, significant non-linear correlations Subgroup revealed substantial age-related differences ALI as well varying risk across cardiovascular outcomes Systemic significantly Large-scale prospective studies warranted confirm findings elucidate underlying mechanisms.
Language: Английский
Citations
1Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: June 4, 2024
Abstract The present cross-sectional study aimed to explore the relationship between systemic inflammatory indices (SIIs) and anthropometric measures, metabolic, liver function biomarkers in patients with non-alcoholic fatty disease (NAFLD). This was carried out on 238 NAFLD overweight or obesity, aged 18–55 years. Anthropometric measurements were done body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height (WHtR) estimated. Metabolic factors including serum glucose, lipid profile, biomarkers, complete blood cell count assessed after a 24-h fasting state. SIIs ratios of neutrophil lymphocyte (NLR), monocytes (MLR), platelet (PLR), high-density lipoprotein cholesterol (MHR) calculated. Results indicate that apart from PLR, all significantly changed by increasing steatosis severity (all p < 0.05). Moreover, changes NLR showed significant association waist circumference ( = 0.032), BMI 0.047), WHtR 0.002), as well levels sugar 0.045), triglycerides, 0.025) low-density 0.006). findings also relations profile studied SIIs, notably MHR MLR. All exhibited associations some well. positively correlated metabolic risk while, oppositely, PLR considered preventive marker NAFLD.
Language: Английский
Citations
6Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(8), P. 1922 - 1931
Published: May 6, 2024
Language: Английский
Citations
5Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(10)
Published: Oct. 1, 2024
The association between inflammatory score, insulin resistance (IR), and metabolic-associated fatty liver disease (MAFLD) is inconclusive.
Language: Английский
Citations
4Journal of Orthopaedics, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 4595 - 4606
Published: April 1, 2025
Previous research studies have linked the systemic immune inflammation index (SII), derived from a complete blood count, to metabolic dysfunction-associated steatotic liver disease (MASLD). However, evidence on relationship between longitudinal changes in SII and MASLD remains limited. This study aimed explore distinct trajectories their association with incidence. A analyzed 25,600 individuals who underwent periodic health assessments at Dalian City hospital 2014 2023. was diagnosed via ultrasound. The calculated using formula = (platelet count × neutrophil count) / lymphocyte count. Group-based trajectory modeling used identify trajectories, restricted cubic spline (RCS) analysis employed assesse dose-response relationship. Stratified analyses sensitivity were also conducted. Three identified: "low stable" (50.6%), "moderate (35.1%), "high (8.9%). After adjustments, hazard ratios (HR) for incidence 1.118 (95% CI: 1.057-1.182, P<0.001) group 1.284 1.172-1.408, group. These associations persisted after adjusting lifestyle factors. significant non-linear risk found both overall population among different genders. Subgroup consistently confirmed these findings. Elevated levels are significantly associated an increased of MASLD, particularly under 45 women. Regular monitoring may improve stratification facilitate targeted prevention strategies those higher MASLD.
Language: Английский
Citations
0Metabolism, Journal Year: 2025, Volume and Issue: 169, P. 156271 - 156271
Published: April 23, 2025
Language: Английский
Citations
0The Knee, Journal Year: 2025, Volume and Issue: 56, P. 160 - 167
Published: May 30, 2025
Language: Английский
Citations
0