Second‐Generation (44‐Channel) Suprachoroidal Retinal Prosthesis: Surgical Stability and Safety During a 2‐Year Clinical Trial DOI Creative Commons
Penelope J. Allen, Maria Kolic, Elizabeth K. Baglin

et al.

Clinical and Experimental Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

ABSTRACT Background To assess the safety and stability profile of suprachoroidal retinal prosthesis (ScRP) in participants with retinitis pigmentosa (RP) for 2 years from implantation. Methods Four participants, advanced RP bare‐light perception vision were enrolled a prospective, single arm unmasked interventional clinical trial unilaterally implanted 44‐channel ScRP (NCT03406416). Electrical stimulation commenced psychophysics laboratory prior to use local environments. Outcome measures included serious adverse events, implant functionality over 2.0–2.7 years. Results Surgical procedures took 204–260 min uncomplicated. Postoperative recovery was uneventful. Imaging confirmed device position under macula absence trauma. There no events that occurred mild. All electrodes functional at surgery completion, only 3% lost by study end. minor array movement (translational rotational) within first 10–15 weeks only. The electrode retina distance increased as expected fibrous capsule development, but plateaued three four 12 months. Retinal choroidal thicknesses consistent underlying dystrophic disease. Conclusions can be safely space has minimal long‐term impacts on eye, SAEs slight seen Hence, findings indicate approach feasibility further multicentre studies are warranted.

Language: Английский

Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives DOI
Marina França Dias, Kwangsic Joo,

Jessica A. Kemp

et al.

Progress in Retinal and Eye Research, Journal Year: 2017, Volume and Issue: 63, P. 107 - 131

Published: Oct. 31, 2017

Language: Английский

Citations

345
Retinal stimulation strategies to restore vision: Fundamentals and systems DOI Creative Commons
Yue Lan, James D. Weiland, Botond Roska

et al.

Progress in Retinal and Eye Research, Journal Year: 2016, Volume and Issue: 53, P. 21 - 47

Published: May 28, 2016

Language: Английский

Citations

250
Photovoltaic Restoration of Central Vision in Atrophic Age-Related Macular Degeneration DOI Creative Commons
Daniel Palanker, Y. Le Mer, Saddek Mohand‐Saïd

et al.

Ophthalmology, Journal Year: 2020, Volume and Issue: 127(8), P. 1097 - 1104

Published: Feb. 25, 2020

Loss of photoreceptors in atrophic age-related macular degeneration results severe visual impairment, although some peripheral vision is retained. To restore central without compromising the residual field, we developed a wireless photovoltaic retinal implant (PRIMA; Pixium Vision, Paris, France) which pixels convert images projected from video glasses using near-infrared light into electric current to stimulate nearby inner neurons.We carried out first-in-human clinical trial test safety and efficacy prosthesis patients with geographic atrophy (ClinicalTrials.gov identifier, NCT03333954).Five zone at least 3 optic disc diameters, no foveal perception, best-corrected acuity 20/400 20/1000 worse-seeing study eye.The 2-mm wide, 30-μm thick chip, containing 378 (each 100 μm diameter), was implanted subretinally area (absolute scotoma).Anatomic outcomes were assessed fundus photography OCT for up 12 months follow-up. Prosthetic by mapping bar orientation, letter recognition, Landolt C acuity.In all patients, successfully under macula, 2 it unintended locations: within choroid off center mm. All 5 could perceive white-yellow prosthetic patterns adjustable brightness previous scotomata. The optimal placement demonstrated 20/460 20/550, patient off-center 20/800 acuity. Residual natural did not decrease after implantation any patient.Implantation PRIMA acuity, restored sensitivity former scotoma each patients. In proper only 10% 30% less than level expected pixel pitch (20/420). Therefore, use optical or electronic magnification as well smaller future implants may improve even further.

Language: Английский

Citations

194
Stemming retinal regeneration with pluripotent stem cells DOI Creative Commons
Zi‐Bing Jin, Mei-Ling Gao, Wen-Li Deng

et al.

Progress in Retinal and Eye Research, Journal Year: 2018, Volume and Issue: 69, P. 38 - 56

Published: Nov. 9, 2018

Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis pigmentosa (RP) and glaucoma. These diseases are all characterized by the of one or two types that cannot regenerate spontaneously humans. Aberrant pigment epithelial (RPE) cells can be observed through optical coherence tomography (OCT) AMD patients. In RP patients, morphological functional abnormalities RPE photoreceptor layers caused genetic abnormality. disease juvenile degeneration, which loss photoreceptors area, causes central vision at an early age. Loss ganglion (RGCs) patients with Once triggered, no treatments reverse it. Transplantation-based approaches have been proposed universal to target various concomitant diseases. Both dead neuroprotection strategies used rescue visual function animal models degeneration. Diverse derived from pluripotent stem cells, including photoreceptors, RGCs even organoids layered structure, provide unlimited sources transplantation. addition, mesenchymal (MSCs) multifunctional protect degenerating cells. The aim this review summarize current findings preclinical clinical studies. We begin brief introduction degenerative followed methods generation. Preclinical studies discussed, future concerns about efficacy, safety immunorejection also addressed.

Language: Английский

Citations

188
Advances in retinal prosthesis systems DOI Creative Commons
Edward Bloch,

Yvonne Hsu-Lin Luo,

Lyndon da Cruz

et al.

Therapeutic Advances in Ophthalmology, Journal Year: 2019, Volume and Issue: 11

Published: Jan. 1, 2019

Retinal prosthesis systems have undergone significant advances in the past quarter century, resulting development of several different novel surgical and engineering approaches. Encouraging results demonstrated partial visual restoration, with improvement both coarse objective function performance everyday tasks. To date, four received marketing approval for use Europe or United States, numerous others undergoing preclinical clinical evaluation, reflecting established safety profile these devices chronic implantation. This progress represents first notion that field restorative medicine could offer blind patients a hope real measurable benefit. However, there are complex biophysical obstacles still to be overcome, reconcile gap remains between artificial natural vision. Current developments form enhanced image processing algorithms data transfer approaches, combined emerging nanofabrication conductive polymerization techniques, herald an exciting innovative future retinal prosthetics. review provides update prosthetic currently trials while also addressing challenges field, such as assessment functional outcomes ultra-low vision strategies tackling existing hardware software constraints.

Language: Английский

Citations

185
Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis DOI Creative Commons
Laura Ferlauto, Marta Jole Ildelfonsa Airaghi Leccardi, Naïg Aurélia Ludmilla Chenais

et al.

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: March 2, 2018

Abstract Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients received a implant. Inspired intraocular lenses, we designed foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless ganglion cells. Here show that within visual angle 46.3 degrees, POLYRETINA embeds 2215 pixels, which 967 are the central area 5 mm, it is allow implantation through small scleral incision, has hemispherical shape match curvature eye. We demonstrate not cytotoxic respects optical thermal safety standards; accelerated ageing shows lifetime at least 2 years. represents significant progress towards improvement both acuity field with same device, current challenging issue field.

Language: Английский

Citations

163
Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses DOI Creative Commons
Laiming Jiang, Gengxi Lu, Yushun Zeng

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 4, 2022

Abstract Electronic visual prostheses, or biomimetic eyes, have shown the feasibility of restoring functional vision in blind through electrical pulses to initiate neural responses artificially. However, existing prostheses predominantly use wired connections electromagnetic waves for powering and data telemetry, which raises safety concerns couples inefficiently miniaturized implant units. Here, we present a flexible ultrasound-induced retinal stimulating piezo-array that can offer an alternative wireless artificial prosthesis approach evoking percepts individuals. The device integrates two-dimensional with 32-pixel electrodes printed circuit board. Each piezo-element be ultrasonically individually activated, thus, spatially reconfigurable electronic patterns dynamically applied via programmable ultrasound beamlines. As proof concept, demonstrate pattern reconstruction ex vivo murine tissue, showing potential this restore functional, life-enhancing people living blindness.

Language: Английский

Citations

98
Bioelectronics for electrical stimulation: materials, devices and biomedical applications DOI
Ya Huang, Kuanming Yao, Qiang Zhang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712

Published: Jan. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Language: Английский

Citations

24
Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives DOI Creative Commons
Sylvia J. Gasparini, Sílvia Llonch, Oliver Borsch

et al.

Progress in Retinal and Eye Research, Journal Year: 2018, Volume and Issue: 69, P. 1 - 37

Published: Nov. 13, 2018

The mammalian retina displays no intrinsic regenerative capacities, therefore retinal degenerative diseases such as age-related macular degeneration (AMD) or retinitis pigmentosa (RP) result in a permanent loss of the light-sensing photoreceptor cells. photoreceptors leads to vision impairment and, later stages, complete blindness. Several therapeutic strategies have been developed slow down prevent further degeneration, however definitive cure i.e. replacement lost photoreceptors, has not yet established. Cell-based treatment approaches, by means transplantation, studied pre-clinical animal models over last three decades. introduction pluripotent stem cell-derived organoids represents, principle, an unlimited source for generation transplantable human photoreceptors. However, safety, immunological and reproducibility-related issues regarding use cells still need be solved. Moreover, recent finding cytoplasmic material transfer between donor host demands reinterpretation several former transplantation studies. At same time, healthy dysfunctional patient also offers potential alternative strategy intervention. In this review we discuss history current state techniques used assess rescue visual function, prerequisites effective well main roadblocks, including safety immune response graft, that overcome successful clinical translation approaches.

Language: Английский

Citations

160
Electronic retinal implants and artificial vision: journey and present DOI Open Access

J O Mills,

Assad Jalil, Paulo E. Stanga

et al.

Eye, Journal Year: 2017, Volume and Issue: 31(10), P. 1383 - 1398

Published: May 26, 2017

Language: Английский

Citations

117