Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 329 - 374
Published: Nov. 29, 2024
Annual Review of Biomedical Engineering, Journal Year: 2024, Volume and Issue: 26(1), P. 273 - 306
Published: July 3, 2024
Nanomaterials are becoming important tools for vaccine development owing to their tunable and adaptable nature. Unique properties of nanomaterials afford opportunities modulate trafficking through various tissues, complement or augment adjuvant activities, specify antigen valency display. This versatility has enabled recent work designing nanomaterial vaccines a broad range diseases, including cancer, inflammatory infectious diseases. Recent successes nanoparticle during the coronavirus disease 2019 (COVID-19) pandemic have fueled enthusiasm further. In this review, most developments in nanovaccines disease, allergic nanoadjuvants summarized. Additionally, challenges clinical translation unique class materials discussed.
Language: Английский
Citations
7
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106975 - 106975
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: May 15, 2025
Tumor-derived extracellular vesicles (TDEVs) represent a heterogeneous population of (EVs), including exosomes, microvesicles, and apoptotic bodies, which are essential for tumor growth. EVs function as natural carriers bioactive molecules, lipids, proteins, nucleic acids, enabling them to influence regulate complex cellular interactions within the microenvironment (TME). The TDEVs mainly have immunosuppressive functions result inhibitory signals disrupting immune cell anti-tumor activity. They enhance progression evasion by inhibiting effector cells altering critical processes recruitment, polarization, functional suppression different signaling pathways. In this sense, modulate NF-κB pathway, promoting inflammation inducing evasion. Janus kinase (JAK)-signal transducer activator transcription (STAT) is required TDEV-mediated manifestation tumor-supporting features. phosphoinositide 3-kinase (PI3K)/protein B (Akt)/mammalian target rapamycin (mTOR) signaling, necessary metabolic reprogramming, orchestrated TDEV abrogate response drive cancer proliferation. Finally, exosomal cargo can NOD-, LRR-, pyrin domain-containing protein 3 (NLRP3) inflammasome, activating pro-inflammatory responses that development immunomodulation. review, we take deep dive into how affect key We also examine emerging therapeutic approaches aimed at EV-mediated pathways, offering promising avenues novel EV-based immunotherapy.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9590 - 9590
Published: May 31, 2023
Cancer is a major cause of mortality in humans; often, rather than the primary tumor, it presence metastases that are death. Extracellular vesicles (EVs) small structures released by both normal and cancer cells; regarding latter, they have been demonstrated to modulate almost all cancer-related processes, such as invasion, angiogenesis induction, drug resistance, immune evasion. In last years, has become clear how EVs widely involved metastatic dissemination well pre-metastatic niche (PMN) formation. Indeed, order achieve successful process, i.e., penetration cells into distant tissues, shaping favorable environment those tissue, PMN formation, mandatory. This process consists an alteration takes place organ paves way for engraftment growth circulating tumor derived from site. review focuses on role formation dissemination, also reporting studies suggesting biomarkers diseases, possibly liquid biopsy approach.
Language: Английский
Citations
8
Microbial Pathogenesis, Journal Year: 2023, Volume and Issue: 185, P. 106440 - 106440
Published: Nov. 5, 2023
Language: Английский
Citations
6
Extracellular Vesicles and Circulating Nucleic Acids, Journal Year: 2024, Volume and Issue: 5(2), P. 297 - 328
Published: June 18, 2024
Host-bacteria and bacteria-bacteria interactions can be facilitated by extracellular vesicles (EVs) secreted both human bacterial cells. Human EVs (BEVs) propagate transfer immunogenic cargos that may elicit immune responses in nearby or distant recipient cells/tissues. Hence, direct colonization of tissues cells is not required for stimulation. This phenomenon important the feto-maternal interface, where optimum tolerance between mother fetus a successful pregnancy. Though intrauterine cavity widely considered sterile, BEVs from diverse sources have been identified placenta amniotic cavity. These internalized cells, which help them evade host surveillance. it appears logical, whether internalize EV cargo yet to determined. However, presence placental believed trigger low-grade response primes fetal system ex-utero survival, but insufficient disrupt progression pregnancy cause intolerance adverse events. Nevertheless, exchange bioactive BEVs, mechanical underpinnings health implications such interactions, especially during pregnancy, are still understudied. Therefore, while focusing on we discussed how take up their cargo, cell (feto-maternal) inflammatory BEV stimulation, associations these with priming reproductive outcomes as preeclampsia preterm birth.
Language: Английский
Citations
2
Advanced Science, Journal Year: 2023, Volume and Issue: 11(10)
Published: Dec. 24, 2023
Abstract Acknowledging the neurological symptoms of COVID‐19 and long‐lasting damage even after epidemic ends are common, necessitating ongoing vigilance. Initial investigations suggest that extracellular vesicles (EVs), which assist in evasion host's immune response achieve SARS‐CoV‐2 systemic spreading, contribute to virus's attack on central nervous system (CNS). The pro‐inflammatory, pro‐coagulant, immunomodulatory properties EVs contents may directly drive neuroinflammation cerebral thrombosis COVID‐19. Additionally, have attracted attention as potential candidates for targeted therapy due their innate homing properties, low immunogenicity, ability cross blood‐brain barrier (BBB) freely. Mesenchymal stromal/stem cell (MSCs) secreted widely applied evaluated patients with therapeutic effect, considering limited antiviral treatment. This review summarizes involvement neuropathology carriers or other pathogenic contents, predictors by transporting brain‐derived substances, agents delivering biotherapeutic substances drugs. Understanding diverse roles neuropathological aspects provides a comprehensive framework developing, treating, preventing severe consequences associated disease.
Language: Английский
Citations
2
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 329 - 374
Published: Nov. 29, 2024
Citations
0