Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery

International Journal of Biological Sciences, Journal Year: 2019, Volume and Issue: 16(1), P. 116 - 134

Published: Dec. 6, 2019

Peripheral nerve injury is a complex condition with variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain.Peripheral nerves are fragile in nature can easily get damaged due to acute compression trauma which may lead the sensory motor functions deficits even lifelong disability.After lesion, neuronal cell body becomes disconnected from axon's distal portion site leading axonal degeneration dismantlement neuromuscular junctions targeted muscles.In spite extensive research on this aspect, complete functional recovery still remains challenge be resolved.This review highlights detailed pathophysiological events after an peripheral associated factors that either hinder promote regenerative machinery.In addition, it throws light available therapeutic strategies including supporting therapies, surgical non-surgical interventions ameliorate regeneration, survival, reinnervation targets.Despite availability various treatment options, we lacking optimal treatments for perfect regain.The need present age discover design potent compounds would able execute retrieval.In regard, plant-derived getting more attention several recent reports validate their remedial effects.A plethora plants phytochemicals have been suggested curative effects against number diseases general particular.They ray hope suffering individuals.

Language: Английский

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Biodegradable Polymers as the Pivotal Player in the Design of Tissue Engineering Scaffolds

Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 9(13)

Published: May 19, 2020

Abstract Biodegradable polymers play a pivotal role in situ tissue engineering. Utilizing various technologies, researchers have been able to fabricate 3D engineering scaffolds using biodegradable polymers. They serve as temporary templates, providing physical and biochemical signals the cells determining successful outcome of remodeling. Furthermore, scaffold also presents fourth dimension for engineering, namely time. The properties polymer change over time, presenting continuously changing features during degradation process. These changes become more complicated when different materials are combined together composite or heterogeneous scaffold. This review undertakes systematic analysis basic characteristics describe recent advances making regenerative medicine. interaction between implanted biomaterials vivo environment discussed, including functional degradable scaffold, local effect on contiguous their evaluation both vitro models.

Language: Английский

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Injectable Hydrogels for Cardiac Tissue Engineering

Macromolecular Bioscience, Journal Year: 2018, Volume and Issue: 18(6)

Published: May 7, 2018

In light of the limited efficacy current treatments for cardiac regeneration, tissue engineering approaches have been explored their potential to provide mechanical support injured tissues, deliver cardio-protective molecules, and improve cell-based therapeutic techniques. Injectable hydrogels are a particularly appealing system as they hold promise minimally invasive approach. Moreover, injectable acellular alginate-based tested clinically in patients with myocardial infarction (MI) show preservation left ventricular (LV) indices ejection fraction (LVEF). This review provides an overview recent developments that occurred design various hydrogel systems efforts, including comparison natural versus synthetic emphasis on ideal characteristics biomimetic materials.

Language: Английский

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The influence of platelet-derived products on angiogenesis and tissue repair: a concise update

Frontiers in Physiology, Journal Year: 2015, Volume and Issue: 6

Published: Oct. 20, 2015

Platelet degranulation allows the release of a large amount soluble mediators, is an essential step for wound healing initiation, and stimulates clotting angiogenesis. The latter process one most critical biological events observed during tissue repair, increasing growth blood vessels in maturing wound. Angiogenesis requires action variety factors that act appropriate physiological ratio to assure functional vessel restoration. Platelets main regulators angiogenesis: Vascular Endothelial Growth Factors (VEGFs), basic fibroblast factor (FGF-2), derived (PDGFs), among others. In order stimulate platelet fractions have been used as autologous source biomolecules, namely Rich Plasma (PRP), Poor (PPP) Fibrin (PRF). continuous these has proposed promote angiogenesis both vitro vivo. Considering existence clinical trials currently evaluating efficacy PRP, present review analyses fundamental questions regarding putative role evaluates possible implications formulations.

Language: Английский

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On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

Bone Research, Journal Year: 2021, Volume and Issue: 9(1)

Published: Feb. 11, 2021

Abstract The demand for biomaterials that promote the repair, replacement, or restoration of hard and soft tissues continues to grow as population ages. Traditionally, smart have been thought those respond stimuli. However, continuous evolution field warrants a fresh look at concept smartness biomaterials. This review presents redefinition term “Smart Biomaterial” discusses recent advances in applications tissue regeneration. To clarify use “smart biomaterials”, we propose four degrees according level interaction with bio-environment biological/cellular responses they elicit, defining these materials inert, active, responsive, autonomous. Then, present an up-to-date survey tissues, based on materials’ (external internal stimuli) their immune-modulatory Finally, discuss limitations obstacles translation from basic research (bench) clinical utilization is required development clinically relevant technologies.

Language: Английский

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