lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)

Published: Jan. 9, 2024

Language: Английский

---

Coumarins from carcinogenic phenol: synthesis, characterization, in silico, biosafety, anticancer, antioxidant, and anti-inflammatory assessments

Chemical Papers, Journal Year: 2023, Volume and Issue: 78(1), P. 493 - 504

Published: Oct. 9, 2023

Language: Английский

---

Chili pepper: A delve into its nutritional values and roles in food-based therapy

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100928 - 100928

Published: Feb. 16, 2025

Language: Английский

---

Molecular Mechanisms in Tumorigenesis of Hepatocellular Carcinoma and in Target Treatments—An Overview

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 656 - 656

Published: June 4, 2024

Hepatocellular carcinoma is the most common primary malignancy of liver, with hepatocellular differentiation. It ranked sixth among cancers worldwide and third leading cause cancer-related deaths. The important etiological factors discussed here are viral infection (HBV, HCV), exposure to aflatoxin B1, metabolic syndrome, obesity (as an independent factor). Directly or indirectly, they induce chromosomal aberrations, mutations, epigenetic changes in specific genes involved intracellular signaling pathways, responsible for synthesis growth factors, cell proliferation, differentiation, survival, metastasis process (including epithelial–mesenchymal transition expression adhesion molecules), angiogenesis. All these disrupted molecular mechanisms contribute hepatocarcinogenesis. Furthermore, equally interaction between tumor cells components microenvironment: inflammatory macrophages—predominantly a pro-tumoral role—hepatic stellate cells, tumor-associated fibroblasts, cancer stem extracellular vesicles, matrix. In this paper, we reviewed biology intricate hepatocarcinogenesis, highlighted how certain pathways can be pharmacologically influenced at various levels molecules. Additionally, mentioned several examples recent clinical trials briefly described current treatment protocol according NCCN guidelines.

Language: Английский

---

Linear pyranocoumarins are potential dazzling dancers between nature, chemistry, and clinical application

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100785 - 100785

Published: March 1, 2025

Language: Английский

---

Cancer cell-derived exosomal miR-34a inhibits the malignant progression of pancreatic adenocarcinoma cells by restraining the M2 polarization of macrophages

European Journal of Histochemistry, Journal Year: 2025, Volume and Issue: 69(2)

Published: April 17, 2025

This study aimed to investigate the crosstalk mechanism between pancreatic cancer (PAC) cells and M2 tumor-associated macrophages induced by tumor-derived exosomal miR-34a. MicroRNA mRNA expression levels were detected using RT-qPCR. Cell Counting Kit-8, wound-healing, transwell assays flow cytometry respectively employed assess cell proliferation, migration, invasion apoptosis. Enzyme-linked immunosorbent assay was utilized determine cytokine secretion. Transmission electron microscopy nanoparticle tracking analyses performed detect exosome morphology particle size. Phagocytosis of exosomes verified PKH26 labeling. The effects exosome-treated on epithelial-mesenchymal transition, invasion, migration PANC-1 investigated coculture experiments. identification miR-34a's potential targets determined with TargetScan validated a dual-luciferase reporter assay. miR-34a expressed at low in PAC tissues, cells, exosomes. overexpression restrains malignant progression cells. After miR-34a-overexpressed PANC-1-derived phagocytosed macrophages, process polarization obstructed, leading suppression cocultured Suppressor signaling 3 is direct target MiR-34a negatively modulates suppressor prevent engaging Janus kinase/signal transducers activators transcription pathway influencing malignancy cell-derived inhibits restraining macrophages.

Language: Английский

---

E-Cadherin and its signaling pathways: A novel target of dietary components in modulating cell migration and proliferation

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 146, P. 104398 - 104398

Published: Feb. 22, 2024

Language: Английский

---

Protective Effects of Carvacrol on Mercuric Chloride‐Induced Lung Toxicity Through Modulating Oxidative Stress, Apoptosis, Inflammation, and Autophagy

Environmental Toxicology, Journal Year: 2024, Volume and Issue: 39(12), P. 5227 - 5237

Published: Aug. 6, 2024

ABSTRACT Mercuric chloride (HgCl 2 ) is extremely toxic to both humans and animals. It could be absorbed via ingestion, inhalation, skin contact. Exposure HgCl can cause severe health effects, including damages the gastrointestinal, respiratory, central nervous systems. The purpose of this work was explore if carvacrol (CRV) protect rats lungs from damage caused by . Intraperitoneal injections at a dose 1.23 mg/kg body weight were given either alone or in conjunction with oral CRV administration doses 25 50 for 7 days. study included biochemical histological techniques examine lung tissue's oxidative stress, apoptosis, inflammation, autophagy processes. ‐induced reductions GSH levels antioxidant enzymes (SOD, CAT, GPx) activity enhanced co‐administration. Furthermore, MDA lowered CRV. inflammatory mediators NF‐κB, IκB, NLRP3, TNF‐α, IL‐1β, IL6, COX‐2, iNOS all reduced When exposed , apoptotic Bax, caspase‐3, Apaf1, p53, caspase‐6, caspase‐9 increased, but antiapoptotic Bcl‐2 after treatment. decreased Beclin‐1, LC3A, LC3B, which turn damage. After treatment, higher pathological observed terms alveolar septal thickening, congestion, edema, cell infiltration compared control group while ameliorated these effects. Consequently, preventing increases stress corresponding autophagy, disturbance tissue integrity tissues, might seen as useful therapeutic alternative.

Language: Английский

---

Circular RNAs and the JAK/STAT pathway: New frontiers in cancer therapeutics

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155408 - 155408

Published: June 13, 2024

Language: Английский

---

Blockade of PD‐1 and CTLA‐4: A potent immunotherapeutic approach for hepatocellular carcinoma

BioFactors, Journal Year: 2023, Volume and Issue: 50(2), P. 250 - 265

Published: Nov. 3, 2023

Abstract Immune checkpoints (ICPs) can promote tumor growth and prevent immunity‐induced cancer cell apoptosis. Fortunately, targeting ICPs, such as programmed death 1 (PD‐1) or cytotoxic T lymphocyte associated protein 4 (CTLA‐4), has achieved great success in the past few years gradually become an effective treatment for cancers, including hepatocellular carcinoma (HCC). However, many patients do not respond to ICP therapy due acquired resistance recurrence. Therefore, clarifying specific mechanisms of development HCC is very important enhancing efficacy anti‐PD‐1 anti‐CTLA‐4 therapy. In particular, antigen presentation interferon‐γ (IFN‐γ) signaling were reported be involved resistance. this review, we have explained role regulatory pathology. Moreover, also elaborated on combinations inhibitors other treatments enhance antitumor effect. Collectively, recent advances pharmacological ICPs provide insights a novel alternative HCC.

Language: Английский

---