The tale of SOX2: Focusing on lncRNA regulation in cancer progression and therapy

Life Sciences, Journal Year: 2024, Volume and Issue: 344, P. 122576 - 122576

Published: March 14, 2024

Language: Английский

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Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 9549 - 9571

Published: July 19, 2024

Language: Английский

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LncRNAs orchestration of gastric cancer - particular emphasis on the etiology, diagnosis, and treatment resistance

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(5)

Published: Sept. 26, 2024

Language: Английский

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Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy

Epigenetics & Chromatin, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 15, 2025

Colorectal cancer (CRC) remains one of the most common causes cancer-related mortality worldwide. Its progression is influenced by complex interactions involving genetic, epigenetic, and environmental factors. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs), have been identified as key regulators gene expression, affecting diverse biological processes, notably programmed cell death (PCD). This review aims to explore relationship between ncRNAs PCD in CRC, focusing on how influence survival, proliferation, treatment resistance. A comprehensive literature analysis was conducted examine recent findings role modulating various mechanisms, apoptosis, autophagy, necroptosis, pyroptosis, their impact CRC development therapeutic response. were found significantly regulate pathways, impacting tumor growth, metastasis, sensitivity CRC. Their these pathways highlights potential biomarkers for early detection targets innovative interventions. Understanding involvement regulation offers new insights into biology. The targeted modulation ncRNA-PCD presents promising avenues personalized treatment, which may improve patient outcomes enhancing effectiveness reducing

Language: Английский

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The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1178 - 1189

Published: May 21, 2024

As the deadliest type of primary brain tumor, gliomas represent a significant worldwide health concern. Circular RNA (circRNA), unique non-coding molecule, seems to be one most alluring target molecules involved in pathophysiology many kinds cancers. CircRNAs have been identified as prospective targets and biomarkers for diagnosis treatment numerous disorders, particularly malignancies. Recent research has established clinical link between temozolomide (TMZ) resistance certain circRNA dysregulations glioma tumors. may play therapeutic role controlling or overcoming TMZ provide guidance novel kind individualized therapy. To address biological characteristics circRNAs their potential induce TMZ, this review highlighted summarized possible roles that molecular pathways drug resistance, including Ras/Raf/ERK PI3K/Akt signaling pathway metabolic processes gliomas.

Language: Английский

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Unraveling the influence of LncRNA in gastric cancer pathogenesis: a comprehensive review focus on signaling pathways interplay

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(9)

Published: Aug. 5, 2024

Language: Английский

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Focused Ultrasound as Targeted Therapy for Colorectal Cancer: A Comprehensive Review

Gastrointestinal Disorders, Journal Year: 2024, Volume and Issue: 6(2), P. 380 - 401

Published: April 13, 2024

Traditional cancer treatments have not significantly improved the survival rates for individuals with colorectal cancer. As a result, there is dire need to explore novel treatment modalities that can target cancer-specific niches, transform cold tumors into hot ones, and disrupt tumor niche. Therapeutic focused ultrasound, recognized its capacity induce thermal mechanical impacts on tissue, potentially eliminate cells elicit body’s anticancer reaction by disrupting microenvironment. This article provides an overview of recent developments in employing therapeutic ultrasound (TFUS) enhance natural defenses against cancers. It also discusses studies examining utility TFUS treating patients research indicating potential stimulate response various vitro vivo models. Furthermore, it explores effects immune system highlights safety effectiveness managing cancer, providing relief from pain, improving rates. Given indications may bolster augment therapy clinical preclinical models, has emerge as pivotal tool settings.

Language: Английский

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Exploring the interplay of natural products and long non-coding RNAs in colorectal cancer: pathogenesis, diagnosis, and overcoming drug resistance

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

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Mitoepigenetics pathways and natural compounds: a dual approach to combatting hepatocellular carcinoma

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(12)

Published: Oct. 27, 2024

Language: Английский

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Unraveling the role of LncRNAs in glioblastoma progression: insights into signaling pathways and therapeutic potential

Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 40(1)

Published: Nov. 26, 2024

Language: Английский

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